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  4. Recombinant Mouse RNA-binding protein EWS (Ewsr1)

Recombinant Mouse RNA-binding protein EWS (Ewsr1)

  • 货号：
    CSB-YP736824MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP736824MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP736824MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP736824MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP736824MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Ewsr1
  • Uniprot No.：
  • 别名：
    Ewsr1; Ews; EwshRNA-binding protein EWS
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-655
  • 氨基酸序列
    MASTDYSTYS QAAAQQGYSA YTAQPTQGYA QTTQAYGQQS YGTYGQPTDV SYTQAQTTAT YGQTAYATSY GQPPTGYSTP TAPQAYSQPV QGYGTGTYDS TTATVTTTQA SYAAQTAYGT QPAYPTYGQQ PTATAPTRPQ DGNKPAETSQ PQSSTGGYNQ PSLGYGQSNY SYPQVPGSYP MQPVTAPPSY PPTSYSSSQP TSYDQSSYSQ QNTYGQPSSY GQQSSYGQQS SYGQQPPTSY PPQTGSYSQA PSQYSQQSSS YGQQSSFRQD HPSSMGVYGQ ESGGFSGPGE NRSLSGPDNR GRGRGGFDRG GMSRGGRGGG RGGLGAGERG GFNKPGGPMD EGPDLDLGLP IDPDEDSDNS AIYVQGLNDN VTLDDLADFF KQCGVVKMNK RTGQPMIHIY LDKETGKPKG DATVSYEDPP TAKAAVEWFD GKDFQGSKLK VSLARKKPPM NSMRGGMPPR EGRGMPPPLR GGPGGPGGPG GPMGRMGGRG GDRGGFPPRG PRGSRGNPSG GGNVQHRAGD WQCPNPGCGN QNFAWRTECN QCKAPKPEGF LPPPFPPPGG DRGRGGPGGM RGGRGGLMDR GGPGGMFRGG RGGDRGGFRG GRGMDRGGFG GGRRGGPGGP PGPLMEQMGG RRGGRGGPGK MDKGEHRQER RDRPY
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Might function as a transcriptional repressor.
  • 基因功能参考文献：
    1. the Fox transcription factor binding motif was frequently observed within EWS-FLI1 peaks and Foxq1 was identified as the cooperative partner that interacts with the EWS portion of EWS-FLI1. PMID: 29945296
    2. s found that FUS, EWS and TAF15 expression is differentially regulated during brain development, both in time and in space. In particular, this study identifies a fine-tuned regulation of FUS and EWS during neuronal differentiation. PMID: 28453628
    3. Gnai1 function is impaired in the spinal cord of Ews/Ewsr1 KO mice PMID: 27534535
    4. EWS is normally O-GlcNAc glycosylated in the brain. PMID: 27903134
    5. glycosylation of EWS protein PMID: 27605304
    6. EWSR1 is involved in the post-transcriptional regulation of Uvrag via a miRNA-dependent pathway, resulting in the deregulation of autophagy inhibition. PMID: 25946189
    7. EWS is essential during the early steps of white adipocyte differentiation, at least in part through its regulation of BMP2 and BMP4 expression. PMID: 25407167
    8. EWS has a role in mitochondrial and cellular energy homeostasis that involves controlling PGC-1alpha protein stability PMID: 25918410
    9. EWS is involved in post-transcriptional regulation of Col4a1 and CTGF via a Drosha-miRNA-dependent pathway. PMID: 24185621
    10. These results demonstrate that EWS is essential for early brown fat lineage determination. PMID: 23987512
    11. these findings suggest that EWS mediates generation of mature let-7g from pre-let-7g. PMID: 22910415
    12. EWS is likely to play a significant role in maintaining the functional capacity of stem cells. PMID: 21030557
    13. EWS has a role in mesodermal cell differentiation PMID: 12509448
    14. Oct-4-mediated transactivation is stimulated by EWS PMID: 15917470
    15. EWS/FLI1 has a role in regulating tumor angiogenesis in Ewing's sarcoma via suppression of thrombospondins TSP1 and TSP2 PMID: 17638877
    16. GLI1 appears to be a transcriptionally deregulated target of EWS/FLI1 that mediates a portion of its tumorigenic phenotype. PMID: 18084326
    17. EWS contributes to start site recognition in TATA-less mammalian promoters. PMID: 18453593

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  • 亚细胞定位：
    Nucleus. Cytoplasm. Cell membrane.
  • 蛋白家族：
    RRM TET family
  • 数据库链接：

    KEGG: mmu:14030

    STRING: 10090.ENSMUSP00000078867

    UniGene: Mm.142822