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  4. Recombinant Mouse RING finger protein 169 (Rnf169)

Recombinant Mouse RING finger protein 169 (Rnf169)

  • 货号：
    CSB-YP019855MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP019855MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP019855MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP019855MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP019855MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Rnf169
  • Uniprot No.：
  • 别名：
    Rnf169; Kiaa1991; E3 ubiquitin-protein ligase RNF169; EC 2.3.2.27; RING finger protein 169; RING-type E3 ubiquitin transferase RNF169
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-694
  • 氨基酸序列
    MAAAGPSTRA SSAAAAAALS RRGRRGRCDE MAAAKAGAPG PASSPALLVL RSAPRPEESG CTGCLETPGE VAALPCSHSR CRGCASRAAG PGCRRCRPRG SGWARRRARD DGQAAAELMG ERARRGQPEP CRPRRDGGAA ASGPRPEPEP LAEPEFIFRT PIKLSKPGEL SEEYGCLRKL RGEKLQEEKD CDDQIHKLLQ EDSEMGKRKA DEQKKRDEAV VLKTSLEQCP ARLSDSENEE PSRGQMMQTH RSAFVSKNSS CSLAFLAGKL NTKVQRSQSC SDTVQDRVRS RLRTAPPNRA KITTITPGST PIIGVLLSTQ NNRCLSAPDL TIEKRLPFGS LSSLASLHKP ERSISPESND SISEELNHFK PIVCSPCTPP KRLPDGRVLS PLIIKSTPRN LTRSLQKQTS YEASPRILKK WEQIFQERQI KKTLSKATLT SLAPEAGEEF PGSDTIHSSK ERPSLAFNTR LSRVQVLSEC AGPTSTALEC FPSVNQTKVE QDCVRKRSRE FSLETCHSSE HGGASSGPSL EREQCEESGS TVDATLVKTC ISTVMKTAAV NSLLPKNDVL GGVLKTKQQL KTLNHFDLGN GILVNSLGEE PIPSLRRGRK RRCKTKHLEQ NGVKKLRPPS SDMDLAPKDP GLLEVGRKLQ QEEEDQQLAL QSHRMFDSER RTMSRRKGSV DQYLLRSSSL AGAK
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Probable E3 ubiquitin-protein ligase that acts as a negative regulator of double-strand breaks (DSBs) repair following DNA damage. Recruited to DSB repair sites by recognizing and binding ubiquitin catalyzed by RNF168 and competes with TP53BP1 and BRCA1 for association with RNF168-modified chromatin, thereby acting as a negative regulator of DSBs repair. E3 ubiquitin-protein ligase activity is not required for regulation of DSBs repair.
  • 亚细胞定位：
    Nucleus, nucleoplasm.
  • 蛋白家族：
    RNF169 family
  • 数据库链接：

    KEGG: mmu:108937

    STRING: 10090.ENSMUSP00000079631

    UniGene: Mm.323087