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  4. Recombinant Mouse REST corepressor 1 (Rcor1)

Recombinant Mouse REST corepressor 1 (Rcor1)

  • 货号：
    CSB-YP019515MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP019515MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP019515MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP019515MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP019515MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Rcor1
  • Uniprot No.：
  • 别名：
    Rcor1; D12Wsu95e; Kiaa0071; REST corepressor 1; Protein CoREST
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-480
  • 氨基酸序列
    MPAMVEKGPEVSG KRRGRNTAAS AASAAASAAS AAASAAASAG TXSASAAAAA SAAAXPNNGQ NKSLAAAAPN GNSGSNSWEE GSSGSSSDEE HGGGGMRVGP QYQAAVPDFD PAKLARRSQE RDNLGMLVWS PNQSLSEAKL DEYIAIAKEK HGYNMEQALG MLFWHKHNIE KSLADLPNFT PFPDEWTVED KVLFEQAFSF HGKTFHRIQQ MLPDKSIASL VKFYYSWKKT RTKTSVMDRH ARKQKREREE SEDELEETNG SNPVDIEIDP NKESKKEVPP TETVPQVKKE KHSTQAKNRA KRKPPKGMFL SQEDVEAVSA NATAATTVLR QLDMELVSIK RQIQNIKQTN SALKEKLDGG IEPYRLPEVI QKCNARWTTE EQLLAVQAIR KYGRDFQAIS DVIGNKSVVQ VKNFFVNYRR RFNIDEVLQE WEAEHGKDET NGPANQKPVK SPESSIKIPE EEDEAASVLD VRYASAS
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Essential component of the BHC complex, a corepressor complex that represses transcription of neuron-specific genes in non-neuronal cells. The BHC complex is recruited at RE1/NRSE sites by REST and acts by deacetylating and demethylating specific sites on histones, thereby acting as a chromatin modifier. In the BHC complex, it serves as a molecular beacon for the recruitment of molecular machinery, including MeCP2 and SUV39H1, that imposes silencing across a chromosomal interval. Plays a central role in demethylation of Lys-4 of histone H3 by promoting demethylase activity of KDM1A on core histones and nucleosomal substrates. It also protects KDM1A from the proteasome. Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development and controls hematopoietic differentiation.
  • 基因功能参考文献：
    1. Rcor1 promotes erythropoiesis by repressing hematopoietic stem cells and/or progenitor genes, as well as the genes and signaling pathways that lead to myeloid cell fate. PMID: 24652990
  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    CoREST family
  • 组织特异性：
    Expressed in the external germinal layer (EGL) and internal granular layer (IGL) of the cerebellum and in Purkinje cells (at protein level).
  • 数据库链接：

    KEGG: mmu:217864

    STRING: 10090.ENSMUSP00000112089

    UniGene: Mm.23808