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  4. Recombinant Mouse Proto-oncogene Wnt-1 (Wnt1)

Recombinant Mouse Proto-oncogene Wnt-1 (Wnt1)

  • 中文名称：
    小鼠Wnt1重组蛋白
  • 货号：
    CSB-YP026128MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Wnt1重组蛋白
  • 货号：
    CSB-EP026128MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Wnt1重组蛋白
  • 货号：
    CSB-BP026128MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Wnt1重组蛋白
  • 货号：
    CSB-MP026128MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    Wnt1; Int-1; Wnt-1Proto-oncogene Wnt-1; Proto-oncogene Int-1
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    28-370
  • 氨基酸序列
    ANS SGRWWGIVNI ASSTNLLTDS KSLQLVLEPS LQLLSRKQRR LIRQNPGILH SVSGGLQSAV RECKWQFRNR RWNCPTAPGP HLFGKIVNRG CRETAFIFAI TSAGVTHSVA RSCSEGSIES CTCDYRRRGP GGPDWHWGGC SDNIDFGRLF GREFVDSGEK GRDLRFLMNL HNNEAGRTTV FSEMRQECKC HGMSGSCTVR TCWMRLPTLR AVGDVLRDRF DGASRVLYGN RGSNRASRAE LLRLEPEDPA HKPPSPHDLV YFEKSPNFCT YSGRLGTAGT AGRACNSSSP ALDGCELLCC GRGHRTRTQR VTERCNCTFH WCCHVSCRNC THTRVLHECL
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Ligand for members of the frizzled family of seven transmembrane receptors. Acts in the canonical Wnt signaling pathway by promoting beta-catenin-dependent transcriptional activation. In some developmental processes, is also a ligand for the coreceptor RYK, thus triggering Wnt signaling. Plays an essential role in the development of the embryonic brain and central nervous system (CNS). Has a role in osteoblast function, bone development and bone homeostasis.
  • 基因功能参考文献：
    1. aberrant expression of AF1q may activate Wnt/beta-catenin signaling and result in podocyte injury. PMID: 29069662
    2. Wnt1a maintains characteristics of dermal papilla cells that induce mouse hair regeneration in a 3D preculture system PMID: 26118627
    3. These data suggested that Wnt/beta-catenin pathway might be a potential target to treat the LPS-induced inflammation in ALI. PMID: 29246763
    4. Wnt signaling regulates airway epithelial stem cells in adult murine submucosal glands. PMID: 27341073
    5. Pax9-dependent Wnt signaling has a role in palatogenesis and cleft palates PMID: 28893947
    6. Data show that autocrine Wnt secretion is important for the survival, chromosomal stability, differentiation, and tumorigenic potential of embryonic stem cells (ESCs). PMID: 28074006
    7. Results demonstrated functional differences in the molecular mechanisms downstream of Wnt1 function in the diencephalon, in relation to the spinal cord. Wnt1 signal determines the patterning of the diencephalic dorso-ventral axis PMID: 26452989
    8. Data show that both transgenic Wnt1-cre and P0-cre are similarly effective in deleting beta-catenin in the neural crest. PMID: 27184910
    9. data suggest that WNT1-related osteogenesis imperfecta and osteoporosis are caused in part by decreased mTORC1-dependent osteoblast function resulting from loss of WNT1 signaling in osteocytes. PMID: 28628032
    10. Administration of EET alters Wnt1, NOV, and HO-1 signaling to prevent obesity-induced cardiomyopathy in obese mice. PMID: 28576832
    11. Data indicate that Wnt1 proto-oncogene protein (WNT1) is the direct target of microRNA miR-34a in dendritic cell (DC). PMID: 28199987
    12. The data obtained from the 14-3-3epsilon/14-3-3zeta/Wnt1-Cre mice strongly indicate the importance of 14-3-3 proteins in the development of melanocyte lineages. PMID: 27001213
    13. High WNT1 promoted stem-ness characteristics and metastasis potential in sphere-forming liver cancer stem cells. PMID: 26735577
    14. Decreased expressions of Wnt1 and Wnt5a. PMID: 26537990
    15. we provide unequivocal evidence that epithelial-derived Wnt1 is sufficient to drive interstitial fibrosis in the absence of any injury. PMID: 26204899
    16. Data show that elongator protein 3 (Elp3) trigger Wnt-driven tumor initiation in the intestine, and Elp3 deficiency strongly impaired radiation-induced intestinal regeneration. PMID: 26527802
    17. Fasudil prevents loss of dopamine neurons in the MPTP mice model of PD through inflammatory inhibition via activation of PI3K/p-Akt and WNT1/Fzd1/beta-catenin cell signaling pathways. PMID: 26045742
    18. Wnt has a role in striatal synaptic degeneration and impaired motor behavior in adult mice PMID: 25318560
    19. Agonists of epoxyeicosatrienoic acids reduce infarct size and ameliorate cardiac dysfunction via activation of HO-1 and Wnt1 canonical pathway. PMID: 25677507
    20. this study gives new insights into transcriptional regulating mechanisms of Wnt-mediated Isl1 expression during cardiomyocyte differentiation. PMID: 24610003
    21. Data show that bone marrow mesenchymal stem cell (BM-MSC)-generated Wnt1a promotes the dermal papilla's ability to induce hair cycling and regeneration. PMID: 24961246
    22. modulates neuronal function, hippocampal neurogenesis, and synaptic plasticity and that downregulation of Wnt signaling could be involved in the cognitive decline associated with aging and also with the physiopathology of Alzheimer's disease (AD). PMID: 25443287
    23. BECN1 suppresses mammary tumorigenesis driven by WNT1 activation and following parity PMID: 25483966
    24. in the absence of retinoid signaling via RARbeta, reduced IGF-1 signaling results in suppression of epithelial-mesenchymal transition and delays tumorigenesis induced by the Wnt1 oncogene PMID: 25422594
    25. results revealed that in Wnt-driven tumors, an attenuation of IGF1R signaling accelerates tumorigenesis and promotes more aggressive phenotypes with potential implications for understanding TNBC pathobiology and treatment PMID: 25092896
    26. The swaying mouse is a model of osteogenesis imperfecta caused by WNT1 mutations. PMID: 24634143
    27. Results indicate an important role for the canonical Wnt/beta-catenin pathway in the dendritic cells (DCs)-mediated regulation of allergic responses in the lung. PMID: 24929002
    28. a broader role for Wnt/beta-catenin signaling in contributing to progenitor cell proliferation in nonhairy epithelia and interfollicular epidermis under homeostasis, is reported. PMID: 24315444
    29. Wnt activation, rather than mature hair follicles, is required for adipocyte generation in murine epidermis. PMID: 24706781
    30. Concomitant expression of Wnt1 and KRASG12D in pancreatic epithelium stimulates development of mucinous cystic neoplasm (MCN)-like lesions in female mice. PMID: 24067880
    31. The results indicate the involvement of Wnt1 and Fzd1 in the pathogenesis and development of amyotrophic lateral sclerosis. PMID: 23553522
    32. Marked elevation of Wnt1 expression in the ventral midbrain is correlated with disruption of the differentiation program of ventral dopaminergic neurons. PMID: 23648512
    33. WNT signaling, which is important in developmental processes of the nervous system, plays a critical role in neuropathic pain after sciatic nerve injury and bone cancer in rodents PMID: 23585476
    34. Lgr4 is critically involved in the maintenance of intestinal homeostasis and protection against inflammatory bowel disease through modulation of the Wnt/beta-catenin signaling pathway PMID: 23393138
    35. Axin2-positive tympanic border cells are Wnt responsive and can act as precursors to sensory epithelial cells in the postnatal cochlea. PMID: 23444352
    36. The spatial and temporal function of Wnt1 in midbrain and cerebellum patterning and in midbrain dopamine neuron development in vivo. PMID: 23444360
    37. Wnt1 and Wnt5a interact genetically and cooperate to promote midbrain DA neuron development in vivo. PMID: 23324743
    38. Matrix rigidity activates Wnt signaling through down-regulation of Dickkopf-1 protein PMID: 23152495
    39. cyclin-dependent kinase 2-associated protein 1 (CDK2AP1), an essential gene for early embryonic development, plays a role in pluripotency of ESC by engaging MBD3 to the promoter region of Wnt signaling genes PMID: 23074223
    40. Wnt1cre/Dicer mice fail to develop neural crest-derived cartilages, therefore, have no middle ear ossicles. PMID: 22778034
    41. Low-dose radiation stimulates neural stem cell proliferation, neurogenesis in the hippocampus, and animal learning, by triggering Wnt/beta-catenin signaling cascades. PMID: 22272614
    42. these results suggest that Wnt1 could enhance tumorigenesis by conferring stem cell properties on breast cancer cells PMID: 22846569
    43. Wnt1 is anti-lymphangiogenic by suppressing melanoma-derived VEGF-C expression. PMID: 22572818
    44. The balancing act between cell proliferation and mucus production to restore barrier integrity seems to depend upon the interplay between the Wnt/beta-catenin and Notch pathways in the transmissible murine colonic hyperplasia model. PMID: 22710872
    45. Dickkopf2 is a Wnt antagonist involved in regulation of glucose metabolism PMID: 22733757
    46. GSK3beta plays an essential role in Ras degradation and inhibition of this degradation pathway by aberrant Wnt/beta-catenin signaling may contribute to Ras-induced transformation in colorectal tumorigenesis PMID: 22494971
    47. Wnt1 expression is related to molecular identity and cell migration in cerebellum development in mice. PMID: 22173107
    48. dermal Wnt signaling/beta-catenin has roles in fibroblast proliferation and in the epidermal hair follicle initiation program PMID: 22434869
    49. lipid modification of Wnt1 is required for Wnt secretion, but not stability PMID: 22046319
    50. Acute ischaemic cardiac injury upregulates Wnt1 in the epicardium & later by fibroblasts in the region of injury. Wnt1 induces them to proliferate & express pro-fibrotic genes. PMID: 22085926

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  • 亚细胞定位：
    Secreted, extracellular space, extracellular matrix. Secreted.
  • 蛋白家族：
    Wnt family
  • 组织特异性：
    Testis and mid-gestational embryos. In the testis, detected only in postmeiotic germ cells undergoing differentiation from round spermatids into mature spermatozoa. In the embryos, expression is restricted to the developing CNS in regions of the neural tu
  • 数据库链接：

    KEGG: mmu:22408

    STRING: 10090.ENSMUSP00000023734

    UniGene: Mm.1123