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  4. Recombinant Mouse Protein unc-93 homolog B1 (Unc93b1), partial

Recombinant Mouse Protein unc-93 homolog B1 (Unc93b1), partial

  • 中文名称：
    小鼠Unc93b1重组蛋白
  • 货号：
    CSB-YP855327MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Unc93b1重组蛋白
  • 货号：
    CSB-EP855327MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Unc93b1重组蛋白
  • 货号：
    CSB-EP855327MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Unc93b1重组蛋白
  • 货号：
    CSB-BP855327MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Unc93b1重组蛋白
  • 货号：
    CSB-MP855327MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Unc93b1
  • Uniprot No.：
  • 别名：
    Unc93b1; Unc93b; Protein unc-93 homolog B1; Unc-93B1
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Plays an important role in innate and adaptive immunity by regulating nucleotide-sensing Toll-like receptor (TLR) signaling. Required for the transport of a subset of TLRs (including TLR3, TLR7 and TLR9) from the endoplasmic reticulum to endolysosomes where they can engage pathogen nucleotides and activate signaling cascades. May play a role in autoreactive B-cells removal.
  • 基因功能参考文献：
    1. autoantibody production in systemic mercury-induced autoimmunity was dependent on the endosomal TLR transporter UNC93B1 PMID: 29055005
    2. Autophagy contributes to macrophage resistance to Leishmania major. Data, including data from studies in knockout mice, suggest a key resistance mechanism involves endosomal signaling via Tlr3/7/9 in macrophages; macrophages deficient for Tlr3/7/9, Unc93b1, or MyD88 fail to undergo L. major-induced autophagy. (TLR = Toll-like receptor; Unc93b1 = unc-93 homolog B1; MyD88 = myeloid differentiation primary response gene 88) PMID: 28607148
    3. Describe a mechanism for differential sorting of endosomal toll like receptors by UNC93B1. PMID: 23426999
    4. These observations establish a significant role for Unc93b1 in the regulation of the host inflammatory response to CVB3 infection and also reveal potential mediators of host tissue damage that merit further investigation in acute viral myocarditis. PMID: 25675947
    5. Unc93b1 controls activation of both myeloid and lymphoid cells during the innate immune response to influenza. PMID: 24848930
    6. The observations demonstrate for the first time that activation of interferon and estrogen signaling in immune cells up-regulates the expression of murine Unc93b1. PMID: 23728775
    7. Mutation of the acidic residues in TLR3 and TLR9 prevents UNC93B1 binding, and impairs TLR trafficking and renders the mutant receptors incapable of transmitting signals; therefore, the acidic residues in the juxtamembrane region of the nucleotide-sensing TLRs have important functional roles PMID: 23585677
    8. Data indicate that UNC93B1 mutant and triple TLR3/7/9 knock-out mice are highly susceptible to infection with Leishmania major. PMID: 23325805
    9. UNC93B1 mediates innate inflammation and antiviral defense in the liver during acute murine cytomegalovirus infection. PMID: 22723955
    10. UNC93B, but not Toll-like receptors 3, 7, and 9, is required for bacterial RNA-induced IL-1beta production and activation of caspase-1. PMID: 22634614
    11. restricts systemic lethal inflammation by orchestrating Toll-like receptor 7 and 9 trafficking PMID: 21683627
    12. association with UNC93B1 and the intracellular localization of TLRs are not unique features of nucleic acid-sensing TLRs but is also essential for TLR11-dependent recognition of T. gondii profilin and for host protection against this parasite. PMID: 21097503
    13. our results reveal a critical role for UNC93B1 on induction of IL-12/IFNgamma production as well as autonomous control of Toxoplasma replication by macrophages. PMID: 20865117
    14. identified 'triple D' (3d), a recessive N-ethyl-N-nitrosourea-induced mutation and phenotype in which no signaling occurs via the intracellular Toll-like receptors 3, 7 and 9 PMID: 16415873
    15. Study shows that UNC93B specifically interacts with TLR3, 7, 9, and 13, whereas introduction of the point mutation H412R in UNC93B abolishes their interactions. PMID: 17452530
    16. the function of the polytopic membrane protein UNC93B1 is to deliver the nucleotide-sensing receptors TLR7 and TLR9 from the ER to endolysosomes PMID: 18305481
    17. Data suggest that the Toll-like receptor 7/9 response to nucleic acids in dendritic cells is biased toward DNA-sensing by Unc93B1. PMID: 19451267

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  • 亚细胞定位：
    Endoplasmic reticulum membrane; Multi-pass membrane protein. Endosome. Lysosome. Cytoplasmic vesicle, phagosome.
  • 蛋白家族：
    Unc-93 family
  • 数据库链接：

    KEGG: mmu:54445

    STRING: 10090.ENSMUSP00000124272

    UniGene: Mm.262094