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  4. Recombinant Mouse Protein fosB (Fosb)

Recombinant Mouse Protein fosB (Fosb)

  • 货号：
    CSB-YP008791MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP008791MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP008791MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP008791MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP008791MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    FosbProtein fosB
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full length protein
  • 表达区域：
    1-338
  • 氨基酸序列
    MFQAFPGDYD SGSRCSSSPS AESQYLSSVD SFGSPPTAAA SQECAGLGEM PGSFVPTVTA ITTSQDLQWL VQPTLISSMA QSQGQPLASQ PPAVDPYDMP GTSYSTPGLS AYSTGGASGS GGPSTSTTTS GPVSARPARA RPRRPREETL TPEEEEKRRV RRERNKLAAA KCRNRRRELT DRLQAETDQL EEEKAELESE IAELQKEKER LEFVLVAHKP GCKIPYEEGP GPGPLAEVRD LPGSTSAKED GFGWLLPPPP PPPLPFQSSR DAPPNLTASL FTHSEVQVLG DPFPVVSPSY TSSFVLTCPE VSAFAGAQRT SGSEQPSDPL NSPSLLAL
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    FosB interacts with Jun proteins enhancing their DNA binding activity.
  • 基因功能参考文献：
    1. Fosb-targeted histone acetylation in D2-MSNs or histone methylation in D1-MSNs promotes a stress-susceptible, depressive-like phenotype, while histone methylation in D2-MSNs or histone acetylation in D1-MSNs increases resilience to social stress as quantified by social interaction behavior and sucrose preference. PMID: 28462942
    2. study provides key insights into functional domains regulated by FosB in the hippocampus, emphasizing remarkably different programs of gene regulation under physiological and pathological conditions PMID: 29408867
    3. These findings suggest that GosB may regulate mammary epithelial cells milk fat synthesis and apoptosis via PPARgamma in mouse mammary glands. PMID: 29181403
    4. Study investigated effects of chronic variable mild stress (CVMS) in non-injected, vehicle and imipramine-treated KO mice vs. wildtype (WT) counterparts and mapped the CVMS-related FosB response in 18 brain areas; found that PACAP deficiency affects neuronal reactivity in a brain area-specific manner in stress centers PMID: 27282087
    5. abnormal regulation of MSK1 contributes to the development of L-DOPA-induced dyskinesia and to the concomitant increase in striatal FosB, which may occur via increased histone H3 phosphorylation at the fosB promoter PMID: 25193242
    6. The most highly stereotypic mice showed the most elevated FosB/DeltaFosB activity in the nucleus accumbens PMID: 26731014
    7. FosB/DeltaFosB immunoreactivity was transiently increased in hippocampus and parahippocampal cortices by 6-Hz corneal stimulation. FosB induction was primarily localized in pyramidal neurons. PMID: 26555229
    8. This study demonstrate that the DeltaFosB is induced in the hippocampus by learning, regulates the shape of hippocampal synapses, and is required for memory formation, opening up a host of new possibilities for hippocampal transcriptional regulation. PMID: 26446228
    9. These findings confirm the unique role of DeltaFosB in the nucleus accumbens in controlling responses to drugs of abuse and stress. PMID: 25313003
    10. D1Rs play a major role in THC-mediated DeltaFosB induction. PMID: 26099530
    11. Histone methylation or acetylation at the Fosb locus in nucleus accumbens, was sufficient to control drug- and stress-evoked behavioral responses. PMID: 25347353
    12. These results indicate that social stress-induced behavioral deficits are mediated partly by molecular adaptations in mPFC involving DeltaFosB and CCK through cortical projections to distinct subcortical targets. PMID: 24623766
    13. Fosb expression significantly increased corresponding to the DNA methylation level of the gene body in the arsenic-exposed group. PMID: 24118411
    14. Cytisine modulates chronic voluntary ethanol consumption and reduces ethanol-induced up-regulation of striatal DeltaFosB. PMID: 23601929
    15. This study demonistrated that the fosB-null mouse is the first animal model to provide a genetic and molecular basis for the comorbidity between depression and epilepsy with abnormal neurogenesis, all of which are caused by loss of a single gene, fosB. PMID: 23303048
    16. Chronic self-administration of alcohol results in elevated DeltaFosB in brain region and genotype specific of mice. PMID: 23102405
    17. This study demonistrated that in transgenic mice overexpressing DeltaFosB to show that this genetic manipulation enhances the rewarding effects of cocaine. PMID: 21962331
    18. These findings indicate that FosB is essential for stress tolerance mediated by delta-FosB. PMID: 21679928
    19. These results suggest that DeltaFosB signaling in nucleus accumbens mediates adaptive responses to calorie restriction. PMID: 21215388
    20. transcription factor FosB/activating protein-1 (AP-1) activation is a prominent downstream signal of the extracellular nucleotide receptor P2RX7 in monocytic and osteoblastic cells PMID: 20813842
    21. FosB is involved in thermoregulation-independent protective functions against methamphetamine neurotoxicity in postsynaptic neurons. PMID: 19890265
    22. study found DeltaFosB mediates an essential mechanism of resilience; induction of DeltaFosB in nucleus accumbens was both necessary & sufficient for resilience & for fluoxetine to reverse behavioral pathology induced by social defeat PMID: 20473292
    23. In both light and dark phases of the daily cycle, maternal stimulation of DBA/2J mothers following return of their pups evokes an increase in FosB-immunoreactivity in the medial preoptic nucleus. PMID: 12376177
    24. Results suggest that the changes in osteoblast and adipocyte differentiation in DeltaFosB transgenic mice result from independent cell-autonomous mechanisms. PMID: 15024071
    25. Permanent elimination of fosB gene products does not alter ethanol intake but may enhance preference for sweet solutions in mice. PMID: 15276803
    26. Enhanced MMP-2 transcription and translation following I/R injury are mediated by induction, via oxidant stress, of discrete AP-1 transcription factor components, JunB and FosB. PMID: 16699069
    27. Lipopolysaccharide-induced depressive-like behavior was associated with delayed cellular activity assessed by FosB/DeltaFosB immunostaining within the extended amygdala, hippocampus and hypothalamus. PMID: 17482371
    28. Results indicate that inescapable stress-induced accumulation of deltaFosB in the ventrolateral periaqueductal gray desensitizes substance P neurons enriched in this area and opposes behavioral despair by promoting active defense responses. PMID: 17640529
    29. These results suggest the pivotal role of ERK-FosB signaling in the initiation of parental care. PMID: 17707653
    30. Mice lacking fosB are less sensitive to rewarding properties of morphine and display spatial memory impairment; results suggest involvement of fosB and its proteins in motivational aspects of reinforcers as well as in learning and memory processes. PMID: 18407360
    31. DeltaFosB's AP-1 transactivating function is not needed to induce increased bone formation, and Delta2DeltaFosB may act, at least in part, by increasing Smad1 expression, phosphorylation, and translocation to the nucleus PMID: 18433296
    32. Primary osteoblasts overexpressing Delta2Deltafosb protein formed more nodus than the control cells. PMID: 18630601
    33. FosB negatively regulates cell-matrix adhesion and the TGF-beta1 signaling pathway. PMID: 18753407
    34. This study demonstrated that elevation of DeltaFosB not only increases the reward value of drug, but the reward value of the saccharin cue as well. PMID: 19331462

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  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    BZIP family, Fos subfamily
  • 数据库链接：

    KEGG: mmu:14282

    STRING: 10090.ENSMUSP00000003640

    UniGene: Mm.248335