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  4. Recombinant Mouse Protein deltex-1 (Dtx1)

Recombinant Mouse Protein deltex-1 (Dtx1)

  • 货号：
    CSB-YP723395MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP723395MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP723395MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP723395MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP723395MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    Dtx1E3 ubiquitin-protein ligase DTX1; EC 2.3.2.27; FXI-T1; Protein deltex-1; Deltex1; mDTX1; RING-type E3 ubiquitin transferase DTX1
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-627
  • 氨基酸序列
    MSRPGQGVMV PVNGLGFPPQ NVARVVVWEW LNEHSRWRPY TATVCHHIEN VLKEDARGSV VLGQVDAQLV PYIIDLQSMH QFRQDTGTMR PVRRNFYDPS SAPGKGIVWE WENDGGAWTA YDMDICITIQ NAYEKQHPWL DLSSLGFCYL IYFNSMSQMN RQTRRRRRLR RRLDLAYPLT VGSIPKSQSW PVGASSGQPC SCQQCLLVNS TRAASNAILA SQRRKAPIAP AAPPAPPPPP PPLPPGGPPG ALVVRPSATF AGAALWAAPA TGPTEPAPPP GVPPRSPSAP NGAPTPGQNN LSRPGPQRST SVSARASIPP GVPALPVKNL NGTGPVHPAL AGMTGILLCA AGLPVCLTRA PKPILHPPPV SKSDVKPVPG VPGVCRKTKK KHLKKSKNPE DVVRRYMQKV KNPPDEDCTI CMERLVTASG YEGVLRNKSV RPELVGRLGR CGHMYHLLCL VAMYSNGNKD GSLQCPTCKA IYGEKTGTQP PGKMEFHLIP HSLPGFADTQ TIRIVYDIPT GIQGPEHPNP GKKFTARGFP RHCYLPNNEK GRKVLRLLIT AWERRLIFTI GTSNTTGESD TVVWNEIHHK TEFGSNLTGH GYPDASYLDN VLAELTAQGV SEAMAKA
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. Mainly acts as a positive regulator of Notch, but it also acts as a negative regulator, depending on the developmental and cell context. Mediates the antineural activity of Notch, possibly by inhibiting the transcriptional activation mediated by MATCH1. Involved in neurogenesis, lymphogenesis and myogenesis, and may also be involved in MZB (Marginal zone B) cell differentiation. Promotes B-cell development at the expense of T-cell development, suggesting that it can antagonize NOTCH1. Functions as an ubiquitin ligase protein in vivo, mediating ubiquitination and promoting degradation of MEKK1, suggesting that it may regulate the Notch pathway via some ubiquitin ligase activity.
  • 基因功能参考文献：
    1. exerts one level of control on regulatory T-cell stability by sustaining the expression of Foxp3 protein PMID: 25695215
    2. DTX1, similar to Cbl-b and Itch, participates in T cell anergy-induced PKC-theta degradation. there is a coupling of DTX1 to Cbl-b in T cell anergy. PMID: 25000980
    3. NB-3/Notch1 pathway promotes neural progenitor cell differentiation into PMID: 15082708
    4. Deltex selectively suppresses T-cell activation through degradation of a key signaling molecule, MEKK1. PMID: 15684388
    5. Deltex-1 ubiquitin ligase activity is dispensable for mouse development and immune function. PMID: 15684394
    6. Deltex can act as a negative regulator of Notch signals in T cells but that endogenous levels of Deltex1 and Deltex2 are not important for regulating Notch signals during thymocyte development[Deltex1] PMID: 16923970
    7. Data show that Deltex1 ablation enabled Id1-expressing progenitors to differentiate to the DN3 (CD44(-) CD25(+)) stage, which was accompanied by enhanced Notch1 expression in T-cell progenitors. PMID: 19564409
    8. deficiency of DTX1 augmented T cell activation, conferred resistance to anergy induction, enhanced autoantibody generation, and increased inflammation PMID: 19592273

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  • 亚细胞定位：
    Cytoplasm. Nucleus.
  • 蛋白家族：
    Deltex family
  • 组织特异性：
    Predominantly expressed in the brain and testis. Weakly expressed in the thymus, spleen and ovary. Predominantly expressed in regions containing post-mitotic differentiating neurons.
  • 数据库链接：

    KEGG: mmu:14357

    STRING: 10090.ENSMUSP00000031607

    UniGene: Mm.1645