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Recombinant Mouse Protein cappuccino (Cno)

  • 中文名称：
    Recombinant Mouse Protein cappuccino(Cno),Yeast
  • 货号：
    CSB-YP848694MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    Recombinant Mouse Protein cappuccino(Cno),Yeast
  • 货号：
    CSB-EP848694MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    Recombinant Mouse Protein cappuccino(Cno),Yeast
  • 货号：
    CSB-EP848694MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    Recombinant Mouse Protein cappuccino(Cno),Yeast
  • 货号：
    CSB-BP848694MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    Recombinant Mouse Protein cappuccino(Cno),Yeast
  • 货号：
    CSB-MP848694MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Bloc1s4
  • Uniprot No.：
  • 别名：
    Bloc1s4; CnoBiogenesis of lysosome-related organelles complex 1 subunit 4; BLOC-1 subunit 4; Protein cappuccino homolog
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-215
  • 氨基酸序列
    MEEGPAVGTL SREVSTEEAE PLGAAWSGDS GHVSQSHSSA SGPWDDDGPE DAPGRDLPLL RRAASGYASS LLPSAGPRPE VEALDASLEE LLAKVDEFVG MLDMIRGDSS HVVGEGVPRI HAKAAEMRRI YGRIDKLEAF VRMIGSSVAR MEEQVAKAEA ELGTFPRAFR RLLHTISVPA LFRSAPSGPQ RAAYEPPVLF RTEDHFPGCG DRPQL
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. Plays a role in intracellular vesicle trafficking.
  • 基因功能参考文献：
    1. coassembles with pallidin and the muted protein in the BLOC-1 complex PMID: 12576321
    2. Genetic analysis revealed a deleterious mutation in the cappuccino gene (cno), which is profoundly involved in platelet function in the progression of immune complex crescentic glomerulonephritis. PMID: 16948132
  • 相关疾病：
    Defects in Cno are the cause of the cappuccino (Cno) mutant, which is characterized by a severe oculocutaneous albinism due to abnormal melanosome formation, and prolonged bleeding due to deficiency of platelet dense body contents.
  • 亚细胞定位：
    Cytoplasm.
  • 蛋白家族：
    BLOC1S4 family
  • 组织特异性：
    Widely expressed.
  • 数据库链接：

    KEGG: mmu:117197

    STRING: 10090.ENSMUSP00000071840

    UniGene: Mm.46744