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  4. Recombinant Mouse Protein RD3 (Rd3)

Recombinant Mouse Protein RD3 (Rd3)

  • 货号：
    CSB-YP805945MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP805945MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP805945MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP805945MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP805945MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Rd3
  • Uniprot No.：
  • 别名：
    Rd3; Protein RD3; Retinal degeneration protein 3
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-195
  • 氨基酸序列
    MSLIPWLRWN DTPPRLSART PAEMVLETLM MELAGQMREV ERQQRERRSA VRKICTGVDY SWLANTPRPT YDISPGERLQ LEDVCAKIHP SYCGPAILRF RQLLAEREPE VQEVARLFRS VLQEALEKMK QEEEAHKLTR QWSLRPRGSL SSFKTRARIA PFASDIRTIS EDVERDAPPP PRTWSMPEFR APQAD
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Plays a critical role in the regulation of enzymes involved in nucleotide cycle in photoreceptors. Inhibits the basal catalytic activity and the GCAP-stimulated activity of GUCY2E and GUCY2F, two retinal guanylyl cyclases involved in the production of cGMP in photoreceptors. Involved in the transport of GUCY2E and GUCY2F to their target sites in the photoreceptor outer segment. Up-regulates the activity of GUK1, a kinase that plays also an essential role for recycling GMP and indirectly, cGMP. Plays an important role for the survival of rods and cones in the retina.
  • 基因功能参考文献：
    1. Study describes a mouse model of Leber's Congenital Amaurosis type 1 and 12 with autosomal recessive mutation in rd3 gene. The substitution mutation in the Rd3 gene is predicted to cause a stop codon after residue 106. PMID: 27150101
    2. the main RetGC-binding interface on RD3 required for the negative regulation of the cyclase localizes to the Lys(87)-Leu(122) region. PMID: 27471269
    3. Direct association between RD3 and GCAP1 is important for GC1 targeting. PMID: 25477517
    4. Studies indicate that RD3 plays an essential role in the exit of guanylate cyclase from the endoplasmic reticulum and its trafficking to photoreceptor outer segments. PMID: 23740938
    5. Changes in gene expression associated with photoreceptor degeneration in the rd3 mouse model of Leber congenital amaurosis (LCA) type 12, are characterized. PMID: 23687432
    6. photoreceptor degeneration in the rd3 mouse, rcd2 dog, and LCA12 patients is caused by impaired RD3-mediated guanylate cyclase expression and trafficking PMID: 21078983
    7. Rd3 is preferentially expressed in the retina and exhibits increasing expression through early postnatal development. PMID: 17186464

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  • 亚细胞定位：
    Cell projection, cilium, photoreceptor outer segment. Photoreceptor inner segment. Endosome. Nucleus. Cytoplasm. Cytoplasm, perinuclear region.
  • 组织特异性：
    Expressed in the retina and in particular in the inner nuclear layer, in rod and cone outer segments, in the outer nuclear layer, in the outer plexiform layer and in the ganglion cell layer.
  • 数据库链接：

    KEGG: mmu:74023

    STRING: 10090.ENSMUSP00000050188

    UniGene: Mm.274393