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  4. Recombinant Mouse Protein LYRIC (Mtdh), partial

Recombinant Mouse Protein LYRIC (Mtdh), partial

  • 货号：
    CSB-YP770479MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP770479MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP770479MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP770479MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP770479MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Mtdh
  • Uniprot No.：
  • 别名：
    Mtdh; LyricProtein LYRIC; 3D3/LYRIC; Lysine-rich CEACAM1 co-isolated protein; Metadherin; Metastasis adhesion protein
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Downregulates SLC1A2/EAAT2 promoter activity when expressed ectopically. Activates the nuclear factor kappa-B (NF-kappa-B) transcription factor. Promotes anchorage-independent growth of immortalized melanocytes and astrocytes which is a key component in tumor cell expansion. Promotes lung metastasis and also has an effect on bone and brain metastasis, possibly by enhancing the seeding of tumor cells to the target organ endothelium. Induces chemoresistance.
  • 基因功能参考文献：
    1. Data show MTDH mRNA expression upregulated in cervical cancer tissues and inversely correlated with miR-433 expression. Its knockdown showed similar tumor-suppressive roles as miR-433 overexpression in regards to cervical cancer cell proliferation, invasion and apoptosis. MTDH overexpression markedly reversed the effects of miR-433 overexpression in regards to proliferation, invasion and of cervical cancer cells. PMID: 29130111
    2. Up regulation of AEG protein plays a role in the pathogenesis of NAFLD. PMID: 28437865
    3. miR-26a is capable of suppressing the proliferation and migration of ESCC cells via negative regulation of metadherin PMID: 28174206
    4. Mtdh is a potent modulator of podocyte apoptosis. PMID: 27882943
    5. AEG-1 thus might play a role in NTIS associated with HCC and other cancers. PMID: 25944909
    6. When fed a high fat and cholesterol diet (HFD), WT mice rapidly gained weight, whereas AEG-1 KO mice did not gain weight at all. PMID: 26070567
    7. MTDH has a critical role in male fertility and the DNA repair mechanisms required for normal spermatogenesis PMID: 25787082
    8. Data provide evidence that MTDH has a functional role in the progression and metastatic spread of ovarian cancer. PMID: 25346496
    9. RNA-sequencing analysis identified a unique gene signature in livers of Alb/AEG-1/c-Myc mice that was not observed when either AEG-1 or c-Myc was overexpressed PMID: 25065684
    10. Findings establish a pivotal role for MTDH in prostate cancer progression and metastasis. PMID: 25074613
    11. IL-1beta- or TNF-alpha-induced AEG-1 interaction with NF-kappaB p65 subunit. PMID: 24855648
    12. The present findings report the novel role of AEG-1 in mediating reactive astrogliosis and in regulating astrocyte responses to injury. PMID: 22884085
    13. miR-375 targets AEG-1 in HCC and suppresses liver cancer cell growth in vitro and in vivo PMID: 22056881
    14. MTDH may promote hepatocellular carcinoma metastasis through the induction of epithelial-mesenchymal transition process PMID: 21976539
    15. AEG-1 may contribute to cell proliferation during the early development. AEG-1 expression was detected in the developing brain, the neural tube, skin and liver, which correlates with organ sites in which AEG-1 has been implicated in cancer development. PMID: 20736086
    16. although AEG-1 does not affect MDR1 gene transcription, it facilitates association of MDR1 mRNA to polysomes, resulting in increased translation PMID: 20388796
    17. Lyric is localized to the membrane of the endoplasmic reticulum, nuclear envelope, and the nucleolus. PMID: 14980505
    18. overexpression of metadherin is associated with metastatic breast cancer PMID: 15093543

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  • 亚细胞定位：
    Endoplasmic reticulum membrane; Single-pass membrane protein. Nucleus membrane; Single-pass membrane protein. Cell junction, tight junction. Nucleus, nucleolus. Cytoplasm, perinuclear region.
  • 组织特异性：
    In the mammary gland, expressed at the apical surface of epithelial cells lining ducts, as well as in the mammary fat pad. Not detected in the spleen, kidney, lung, or skin; minute amounts seen in the liver. Expressed in Purkinje neurons in the early post
  • 数据库链接：

    KEGG: mmu:67154

    STRING: 10090.ENSMUSP00000022865

    UniGene: Mm.130883