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  4. Recombinant Mouse Protein IWS1 homolog (Iws1)

Recombinant Mouse Protein IWS1 homolog (Iws1)

  • 货号：
    CSB-YP806957MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP806957MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP806957MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP806957MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP806957MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Iws1
  • Uniprot No.：
  • 别名：
    Iws1; Iws1lProtein IWS1 homolog; IWS1-like protein
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-766
  • 氨基酸序列
    MDSEYYSGDQ SDDGGATPVQ DERDSGSDGE DGVTEQHSGS DTGSVDHHSE NETSDREDGL AKIHNGTDSE NDEPSNANAS DSESEELHRP KDSDSDSEEH AESPASDSEN EPVNQHGSDS ENEELLNGHA SDSEKEEVSK HAASDSEAED TLQPQVSESD SEDPPRPQAS DSENEEPPKP RISDSESEEL PKPRVSDSES EDPPRPQASD SESEELPKPR VSDSESEDPP RPQASDSESE ELPKPRVSDS ESEDPQKGPA SDSEAEDASR HKEKPDSDDS DGENKREDSE VQNESDGHTD RKGLHSSDSE EEEPKRQKID SDDDEEKEGD EEKVAKRKAA VLSDSEDDAG NASAKKSRVV CDADDSDSDV VSDKSGKRET TVASDSEEEA GKEESSVKKK EDKDLFGSDS ESGNEEENLI ADIFGESGDE EEEEFTGFNQ EDLEEEKNET QLKEAEDSDS DDNIKRGKHM DFLSDFEMML QRKKSMCGKR RRNRDGGTFI SDADDVVSAM IVKMNEAAEE DRQLNNQKKP ALKKLTLLPT VVMHLKKQDL KETFIDSGVM SAIKEWLSPL PDRSLPALKI REELLKILQE LPSVSQETLK HSGIGRAVMY LYKHPKESRS NKDMAGKLIN EWSRPIFGLT SNYKGMTREE REQRDLEQMP QRRRLSSTGG QTPRRDLEKV LTGEEKALRP GDPGFCARAR VPMPSNKDYV VRPKWNVEME SSRFQASSKK GISRLDKQMR KFTDIRKKSR SAHAVKISIE GNKMPL
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Transcription factor which plays a key role in defining the composition of the RNA polymerase II (RNAPII) elongation complex and in modulating the production of mature mRNA transcripts. Acts as an assembly factor to recruit various factors to the RNAPII elongation complex and is recruited to the complex via binding to the transcription elongation factor SUPT6H bound to the C-terminal domain (CTD) of the RNAPII subunit RPB1 (POLR2A). The SUPT6H:IWS1:CTD complex recruits mRNA export factors (ALYREF/THOC4, EXOSC10) as well as histone modifying enzymes (such as SETD2) to ensure proper mRNA splicing, efficient mRNA export and elongation-coupled H3K36 methylation, a signature chromatin mark of active transcription.
  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    IWS1 family
  • 组织特异性：
    Ubiquitous. Expressed at highest level in kidney, then testicle, large intestine, small intestine, spleen and prostate, whereas the lowest level is detected in heart.
  • 数据库链接：

    KEGG: mmu:73473

    STRING: 10090.ENSMUSP00000025243

    UniGene: Mm.66853