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  4. Recombinant Mouse Protein FEV (Fev)

Recombinant Mouse Protein FEV (Fev)

  • 货号：
    CSB-YP844421MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP844421MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP844421MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP844421MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP844421MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Fev
  • Uniprot No.：
  • 别名：
    Fev; Pet1Protein FEV; PC12 ETS domain-containing transcription factor 1; PC12 ETS factor 1; Pet-1; mPet-1
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-237
  • 氨基酸序列
    MRQSGTSQPL LINMYLPDPV GDGLFKEGKS PSWGPLSPAV QKGSGQIQLW QFLLELLADR ANAGCIAWEG GHGEFKLTDP DEVARRWGER KSKPNMNYDK LSRALRYYYD KNIMSKVHGK RYAYRFDFQG LAQACQPPPA HAHAAAAAAA AAAAAQDGAL YKLPAGLAPL PFPGLSKLNL MAASAGVAPA GFSYWPGPNA TAAAAATAAL YPTPGLQPPP GPFGAVAAAS HLGGHYH
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Functions as a transcriptional regulator. May function as a transcriptional repressor. Functions in the differentiation and the maintenance of the central serotonergic neurons. May play a role in cell growth.
  • 基因功能参考文献：
    1. These results suggest a causal relationship between 5-HT1A and Pet1, and reveal a potential mechanism by which 5-HT1A-Pet1 autoregulatory loop is maintained by serotonin. PMID: 24972638
    2. novel evidence for the role of Pet-1 in fear processing and dendritic organization of amygdala neurons PMID: 24100022
    3. Pet1-dependent and Pet1-resistant 5-serotonin (5-HT) neurons target different brain centers that might delineate the anatomical basis for a dual serotonergic control on stress responses. PMID: 21414898
    4. The data of this study indicated that, in addition to transcriptional regulation by Pet-1 in raphe neurons, 5-HT1A receptor expression is regulated indirectly by alterations in 5-HT neurotransmission in a region-specific manner PMID: 21182526
    5. This study indicated that Pet-1 is required across the lifespan of the mouse and that behavioral pathogenesis can result from both developmental and adult-onset alterations in serotonergic transcription. PMID: 20818386
    6. Pet-1(-/-) neonates are probably not hypoxic from respiratory dysfunction until P14-15; neither apnea-related hypoxia nor greater hypopnea contribute to the enhanced bradycardias of Pet-1 and there may be enhanced temperature reflex in hyperthermia PMID: 20421636
    7. expressed in central serotonergic (5-hydroxytryptaminergic) neurons located in the mes-/metencephalic raphe nuclei from E11 on until adulthood PMID: 11875656
    8. Pet-1 is a critical determinant of 5-HT neuron identity and Pet-1-dependent program is involved in serotonergic modulation of behavior PMID: 12546819
    9. Ectopic expression of Lmx1b plus Pet-1 is able to induce formation of 5-HT cells in the most ventral spinal cord, where Nkx2.2 is normally expressed. Combined expression of Lmx1b, Pet-1, and Nkx2.2, drives 5-HT differentiation in the dorsal spinal cord PMID: 14602809
    10. Our findings identify a direct transcriptional interaction between Gata-2 and FEV and a unique marker for new insight into FEV/Pet-1 function in 5-HT neuron development. PMID: 19036967

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  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    ETS family
  • 组织特异性：
    Expressed in central serotonergic neurons.
  • 数据库链接：

    KEGG: mmu:260298

    STRING: 10090.ENSMUSP00000070878

    UniGene: Mm.150496