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  4. Recombinant Mouse Protein DEK (Dek)

Recombinant Mouse Protein DEK (Dek)

  • 货号：
    CSB-YP766504MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP766504MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP766504MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-MP766504MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Dek
  • Uniprot No.：
  • 别名：
    DekProtein DEK
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-380
  • 氨基酸序列
    MSAAAAPAAE GEDAPVPPSS EKEPEMPGPR EESEEEEEDD EDDDEEDEEE EKEKSLIVEG KREKKKVERL TMQVSSLQRE PFTVTQGKGQ KLCEIERIHF FLSKKKPDEL RNLHKLLYNR PGTVSSLKKN VGQFSGFPFE KGSTQYKKKE EMLKKFRNAM LKSICEVLDL ERSGVNSELV KRILNFLMHP KPSGKPLPKS KKSSSKGSKK ERNSSGTTRK SKQTKCPEIL SDESSSDEDE KKNKEESSED EEKESEEEQP PKKTSKKEKA KQKATAKSKK SVKSANVKKA DSSTTKKNQK SSKKESESED SSDDEPLIKK LKKPPTDEEL KETVKKLLAD ANLEEVTMKQ ICKEVYENYP AYDLTERKDF IKTTVKELIS
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Involved in chromatin organization.
  • 基因功能参考文献：
    1. These findings define DEK as an important and multifunctional mediator of homologous recombination. PMID: 28317934
    2. DEK is crucial to the development of arthritis in mouse models, thus making it an appropriate target for aptamer-based therapy. PMID: 28165452
    3. DEK was expressed throughout the brain in both sexes, including the medial prefrontal cortex (prelimbic, infralimbic and dorsal peduncular). DEK was also abundant in all amygdalar subdivisions (basolateral, central and medial) and in the hippocampus including the CA1, CA2, CA3, dentate gyrus (DG), ventral subiculum and entorhinal cortex. PMID: 29175155
    4. Dek contributes to esophageal squamous cell carcinoma tumorigenesis at least partially through keratinocyte intrinsic pathways which promote cellular and tumor growth. PMID: 29538372
    5. Data suggests that DEK participates in the process of embryo implantation and might play a role in influencing stromal cell decidualization through mediating cell proliferation, apoptosis and DNA damage. PMID: 29109007
    6. DEK expression during normal hematopoiesis did reveal a relationship with specific cell types implicating a distinct function during myeloid differentiation PMID: 25128083
    7. Studies demonstrate that DEK overexpression, due in part to Ron receptor activation, drives breast cancer progression through the induction of Wnt/beta-catenin signaling. PMID: 24954505
    8. Results highlight a novel function of DEK as a guardian of chromatin by restricting widespread histone access, and in particular by modulating differential H3.3 loading in specific chromatin areas. PMID: 25049225
    9. data demonstrate that DEK stimulates HNSCC cellular growth and identify DeltaNp63 as a novel DEK effector PMID: 24608431
    10. DEK has potent effects on HSCs, HPCs, and hematopoiesis, information of biological and potential clinical interest. PMID: 21943234
    11. The hallmark of translocation in acutte myeloid leukemiaa is the expression of the DEK/CAN fusion protein. PMID: 20827285
    12. DEK is a neuroblastoma tumor antigen. PMID: 17397536
    13. Our conclusion is that DEK could serve as an architectural protein at the promoter or enhancer sites of a subfraction of human genes. PMID: 17524367
    14. Overexpression of the cellular DEK protein promotes epithelial transformation in vitro and in vivo. PMID: 19223548

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  • 亚细胞定位：
    Nucleus.
  • 数据库链接：

    KEGG: mmu:110052

    STRING: 10090.ENSMUSP00000021807

    UniGene: Mm.131150