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  4. Recombinant Mouse Protein C-ets-2 (Ets2)

Recombinant Mouse Protein C-ets-2 (Ets2)

  • 货号：
    CSB-YP007853MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP007853MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP007853MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP007853MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP007853MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    Ets2; Protein C-ets-2
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full length protein
  • 表达区域：
    1-468
  • 氨基酸序列
    MNDFGIKNMD QVAPVANSFR GTLKRQPAFD TFDGSLFAVL PSLSEDQTLQ EVPTGLDSVS HDSASCELPL LTPCSKAVMS QALKATFSGF QKEQRRLGIP KNPWLWSEQQ VCQWLLWATN EFSLVNVNLH QFGMNGQMLC NLGKERFLEL APDFVGDILW EHLEQMIKEN QEKTEDQYEE NSHLNAVPHW INSNTLGFSM EQAPYGMQAP NYPKDNLLDS MCPPSATPAA LGSELQMLPK SRLNTVNVNY CSISQDFPSS NVNLLNNNSG KPKDHDSPEN GGDSFESSDS LLRSWNSQSS LLDVQRVPSF ESFEEDCSQS LCLSKLTMSF KDYIQERSDP VEQGKPVIPA AVLAGFTGSG PIQLWQFLLE LLSDKSCQSF ISWTGDGWEF KLADPDEVAR RWGKRKNKPK MNYEKLSRGL RYYYDKNIIH KTSGKRYVYR FVCDLQNLLG FTPEELHAIL GVQPDTED
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Transcription factor activating transcription. Binds specifically the GGA DNA motif in gene promoters and stimulates transcription of those genes.
  • 基因功能参考文献：
    1. Homozygous deletion of Ets2 in p53 mutant mice resulted in strong down-regulation of snoRNAs and reversed the prometastatic phenotype of mutant p53 but had no effect on osteosarcoma development, which remained 100% penetrant. PMID: 29021240
    2. These results suggest an unappreciated role for ETS2 in fibroblasts in establishing an immune-suppressive microenvironment in response to oncogenic Kras(G12D) signaling during the initial stages of tumor development. PMID: 27659014
    3. The differentiation of ERF-overexpressing trophoblast stem cell lines also suggests that ERF may have an FGF2-independent effect during the commitment towards syncytiotrophoblasts. PMID: 28244611
    4. Elf5 and Ets2 have roles in maintaining the mouse extraembryonic ectoderm in a dosage dependent synergistic manner PMID: 25446535
    5. identified Ets2 as a key novel regulator in both the positive and negative control of miR-155 in the inflammatory response. PMID: 24362029
    6. The data reveals a key function for Ets2 in tumor fibroblasts in signaling to endothelial cells to promote tumor angiogenesis. PMID: 23977064
    7. propose a model that provides a genetic explanation as to how Ets2 in trophoblast mediates the progression of gastrulation within the epiblast PMID: 23552073
    8. Ets-2 play a key role in transcriptional regulation of CTRP5 in muscle cells. PMID: 22740135
    9. Results identify ETS2 as a functionally important transcription factor in adipogenesis. PMID: 21989915
    10. These data indicate the importance of phosphorylated ets-2 in the pathogenesis of pulmonary fibrosis through the expression of Type I collagen and (myo)fibroblast activation. PMID: 21562315
    11. transcriptional cofactor that enhances inflammatory lymphangiogenesis PMID: 21807940
    12. Provide evidence for the plaque-destabilizing role of Ets2 in atherosclerosis development by induction of an intraplaque proinflammatory phenotype in endothelial cells. PMID: 21700929
    13. Ets2 regulates colonic stem cells and sensitivity to tumorigenesis. PMID: 21425406
    14. This study uncovers new roles for Ets2 in trophoblast stem cell self-renewal and differentiation PMID: 20569982
    15. decrease in ETS2 protein levels after exposure to electromagnetic fields PMID: 11887334
    16. Ets2 expression pattern in E8.5 to E13.5 embryos PMID: 12128217
    17. Ets2 plays a role in the proliferation and survival of thymocytes probably via a Myc-dependent pathway. PMID: 12391198
    18. Results demonstrate that Ets-2 and related transcription factors are crucial for the normal formation of the neuromuscular junction and control the expression of a distinct set of synaptic genes. PMID: 12393756
    19. ets-2 has a role as a repressor and indicate that components of the mammalian SNF/SWI complex are required as co-repressors PMID: 12637547
    20. The size of mammary tumors transplanted into fat pads of mice with Ets2 targeted alleles was correlated directly with Ets2 activity. PMID: 14612405
    21. Ets-2 contributes to the up-regulation of HO-1 by the potent inflammatory stimulus LPS in macrophages PMID: 15590657
    22. inactivation of Ets2 within tumor cells has no effect on tumor appearance or growth. By contrast, complete inactivation of Ets2 in both epithelial and stromal cells moderates the early hyperplastic phase of tumor development PMID: 16007139
    23. Ets2 is necessary in the trophoblast for fundamental aspects of anteroposterior (AP) epiblast axis initiation, including mesoderm initiation at the primitive streak PMID: 16481355
    24. Data show that murine cdk10 binds Ets2 transcription factors in vitro, does not show a direct involvement in the G2/M transition and, therefore, does not affect the proliferation rate of the cell lines analyzed. PMID: 16741970
    25. ETS2 repressor factor associates with active and inactive Erks through distinct FXF motifs PMID: 16799155
    26. Ets2 contributes to the regulation of multiple genes important for maintaining the undifferentiated state of trophoblast stem cells and as candidate signals for embryonic development. PMID: 17977525
    27. SRC-1 specifically promotes metastasis without affecting primary tumor growth through mediating Ets-2-mediated HER2 expression and activating CSF-1 expression for macrophage recruitment PMID: 19109434
    28. Evidence for synergy between alterations in GATA-1 and overexpression of ETS proteins in aberrant megakaryopoiesis. PMID: 19168790
    29. Data suggest that Ets-2 transcription factor activation of Bcl-xL gene may protect glia from constitutive oxidative stress that is thought to be a key mechanism contributing to the pathogenesis of amyotrophic lateral sclerosis . PMID: 19179380
    30. Mesoderm-derived cranial skeletal elements are more affected in down syndrome mice, Ets2(+/-) mice compared to littermates, suggesting a differential interaction of Ets2-related processes with mesoderm-derived and neural crest-derived formative tissues. PMID: 19764029

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  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    ETS family
  • 数据库链接：

    KEGG: mmu:23872

    STRING: 10090.ENSMUSP00000023612

    UniGene: Mm.290207