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  4. Recombinant Mouse Protein C-ets-1 (Ets1)

Recombinant Mouse Protein C-ets-1 (Ets1)

  • 货号：
    CSB-YP007852MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP007852MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP007852MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP007852MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP007852MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    Ets1; Ets-1Protein C-ets-1; p54
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full length protein
  • 表达区域：
    1-440
  • 氨基酸序列
    MKAAVDLKPT LTIIKTEKVD LELFPSPDME CADVPLLTPS SKEMMSQALK ATFSGFTKEQ QRLGIPKDPR QWTETHVRDW VMWAVNEFSL KGVDFQKFCM SGAALCALGK ECFLELAPDF VGDILWEHLE ILQKEDVKPY QVNGANPTYP ESCYTSDYFI SYGIEHAQCV PPSEFSEPSF ITESYQTLHP ISSEELLSLK YENDYPSVIL QDPLQTDTLQ TDYFAIKQEV LTPDNMCLGR ASRGKLGGQD SFESVESYDS CDRLTQSWSS QSSFNSLQRV PSYDSFDYED YPAALPNHKP KGTFKDYVRD RADLNKDKPV IPAAALAGYT GSGPIQLWQF LLELLTDKSC QSFISWTGDG WEFKLSDPDE VARRWGKRKN KPKMNYEKLS RGLRYYYDKN IIHKTAGKRY VYRFVCDLQS LLGYTPEELH AMLDVKPDAD
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Transcription factor. Directly controls the expression of cytokine and chemokine genes in a wide variety of different cellular contexts. May control the differentiation, survival and proliferation of lymphoid cells. May also regulate angiogenesis through regulation of expression of genes controlling endothelial cell migration and invasion.
  • 基因功能参考文献：
    1. miR-326 may target the Ets-1 protein to contribute to iodide-induced thyroiditis, providing a new theoretical basis for the use of miRNA targeting therapy for the treatment of autoimmune diseases. PMID: 29181619
    2. results demonstrate that RUNX1, when uncoupled from the requirement for cooperative ETS1 binding, is sufficient to drive long-range loop formation by the enhancer Ebeta, nucleosome clearance at its target promoters, and full transcriptional activation of the TCR beta recombination center PMID: 28637900
    3. data reveal ETS1 as a critical regulator of ILC2 expansion and cytokine production and implicate ETS1 in the regulation of Id2 at the inception of ILC2 development. PMID: 27069114
    4. Ets1 predominantly binds distal nucleosome-occupied regions in double negative thymocytes and nucleosome-depleted regions in double positive thymocytes. importantly, Ets1 induces chromatin remodeling by displacing H3K4me1-marked nucleosomes. PMID: 26673693
    5. reduced lung levels of PPARgamma and increased levels of microRNA-27a (miR-27a), v-ets avian erythroblastosis virus E26 oncogene homolog 1 (ETS1), endothelin-1 (ET-1), and markers of endothelial dysfunction (platelet/endothelial cell adhesion molecule 1 and E selectin). PMID: 27612006
    6. data support a general model in which Ets-1 interacts with nonspecific DNA via dynamic electrostatic interactions, whereas hydrogen bonding drives the formation of well-ordered complexes with specific DNA PMID: 27362745
    7. Ets-1 links glucotoxicity to pancreatic beta cell dysfunction through inhibiting PDX-1 expression in type 2 diabetes. PMID: 26564177
    8. Akt2 upregulates dendritic cell migration at least in part by ETS1-dependent stimulation of IP3R2 transcription. PMID: 24496246
    9. The short nose, otitis media, and hearing impairment in Jacobsen syndrome are likely because of hemizygosity for ETS1 and FLI1. PMID: 26093983
    10. our data suggested that ESE1/ELF3 may promote the UC progression via accelerating NF-kappaB activation and thus facilitating IEC apoptosis. PMID: 25926267
    11. maintenance of appropriate c-ets-1 levels is essential to prevent loss of self-tolerance in the B cell compartment. PMID: 26355157
    12. Data indicate interactions between Ets1 transcription factor and two of its important regulators: Lyn, which maintains Ets1 expression to limit the differentiation of autoreactive plasma cells (PCs), and Btk. PMID: 26209625
    13. our results demonstrate that both Ets1 and miR-155 can directly regulate the expression of CD1d on B-cells PMID: 25929465
    14. Ets-1 has a role in fibronectin-derived heparin-binding domain polypeptides alleviating melanoma cell invasiveness and chemoresistance PMID: 24816403
    15. MicroRNA 17-92 cluster mediates ETS1 and ETS2-dependent RAS-oncogenic transformation PMID: 24968297
    16. Ets-1 overexpression is associated with invasiveness in breast cancer. PMID: 24706481
    17. Data show that proto-oncogene protein Ets1 is downregulated in B cells by B cell receptor signaling. PMID: 24929000
    18. Mediator of neointima formation in arteriovenous fistula PMID: 24203999
    19. The aim of this study was to examine whether expression of microRNA 222 in males and females contributes to changes in the expression of eNOS. PMID: 23632416
    20. Data indicate that differences between the N termini of transcription factors Ets1 and Ets2, rather than differences in the DNA binding domains, determine whether the proteins are capable of blocking antibody-secreting cells (ASCs) formation or not. PMID: 24277931
    21. Ets-1 promotes the expression of IL-2 by modulating the activity of NFAT. PMID: 24019486
    22. ETS1 prevents the binding of ELK3 to EBS2 at low cell density. PMID: 23708702
    23. E-twenty-six (ETS) transcription factors Ets related gene (Erg) and Ets1 are the most common sites for transposon insertion in SB-induced JAK2V617F-positive erythroleukemias PMID: 23533276
    24. These results suggest a critical role for Ets-1 regulation during B cell activation and cell cycle entry. PMID: 23216019
    25. TNF is able to upregulate LT-beta expression in hepatic cells at the transcriptional level by the binding of NF-kappaB p50/p65 heterodimers and Ets1 to their respective sites in the LT-beta promoter. PMID: 22742857
    26. microRNA miR-199a-5p down-regulation switches on wound angiogenesis by derepressing the v-ets erythroblastosis virus E26 oncogene homolog 1-matrix metalloproteinase-1 pathway PMID: 23060436
    27. Data suggest that erythroblastosis virus E26 oncogen homolog-1 (ETS-1) is a common mediator of the proinflammatory and profibrotic effects of Ang II-induced hypertensive renal damage. PMID: 22966006
    28. ETS1 regulates a broad gene expression program in NK cells that promotes target cell recognition while limiting cytokine-driven activation. PMID: 22608498
    29. miR-370 directly regulates BMP-2 and Ets1 expression, at the translational level, during BMP-2-stimulated cell differentiation. PMID: 22587915
    30. Ets-1 is critical for IgG2a CSR and acts as an essential cofactor for Stat1 in the regulation of T-bet expression in B cells. PMID: 22438254
    31. An osteosarcoma zebrafish model implicates Mmp-19 and Ets-1 as well as reduced host immune response in angiogenesis and migration. PMID: 22297719
    32. A physical interaction between Ets-1 and histone deacetylase (HDAC)1 cooperatively downregulates interleukin (IL)-10 gene expression in T helper type (Th)1 cells. PMID: 22266280
    33. The activity of Gata4 cardiac enhancer in transgenic embryos and in cultured aortic endothelial cells is dependent on four ETS sites. PMID: 22056786
    34. The unstructured N-terminus provides 10-fold uniform stabilization of the ground state ERK2*Ets*MgATP complex and intermediates of the enzymatic reaction. PMID: 21494553
    35. Ets-1 directly binds to and activates the CD127 promoter and is a critical regulator of CD127 expression in T cells. PMID: 21148801
    36. Data reveal that elevated expression of Ets1 has a much broader array of pro-tumorigenic effects on epithelial cells than previously appreciated. PMID: 20930145
    37. Down-regulation of miR-208 in BMP-2-stimulated osteoblast differentiation is an important part of the regulatory machinery involved in early osteogenesis. PMID: 20576608
    38. results suggest that Ets-1 activated by the Erk pathway promotes chondrogenic specification and p70S6k activated by both the Erk and Akt pathways plays an important role in gliogenic specification PMID: 20085809
    39. the dynamic helical elements of Ets1, appended to a conserved structural core, constitute a phospho-switch that directs Ras/MAPK signaling to downstream changes in gene expression PMID: 20534573
    40. Results demonstrate that Ets1 is required to direct the proper migration and differentiation of cardiac neural crest in the formation of the interventricular septum, and could play a role in the etiology of human congenital heart disease. PMID: 20356956
    41. Deletion of ETS-1 causes ventricular septal defects and abnormal ventricular morphology in mice. PMID: 19942620
    42. the role of antigen strength-dependent Erk1/2 activation for Ets-1-mediated collaboration with IL-12 in CD8+ T cells. PMID: 19843578
    43. increase in ETS1 mRNA and protein expression after exposure to electromagnetic fields PMID: 11887334
    44. identification of promoter region and binding site for Ets-1 in mouse SERCA3 PMID: 12119294
    45. HIF-2alpha and Ets-1 binding is required for transcriptional activation of Flk-1 in endothelial cells PMID: 12464608
    46. expression of dominant-negative mutant perturbs normal and tumor angiogenesis in a mouse ear model PMID: 12660815
    47. Ets1 has a role in controlling fgl2 expression in endothelial cells PMID: 12752447
    48. data suggest that p42Ets-1 acts as a distinct transcription factor from p51Ets-1 PMID: 14668797
    49. Ets-1 up-regulation is involved in the development of retinal neovascularization PMID: 15111329
    50. ETS-1, PEA3, and ERM have roles in regulation of caveolin-1 transcription in epithelial cells PMID: 15138262

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  • 亚细胞定位：
    Cytoplasm. Nucleus.
  • 蛋白家族：
    ETS family
  • 数据库链接：

    KEGG: mmu:23871

    STRING: 10090.ENSMUSP00000034534

    UniGene: Mm.292415