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  4. Recombinant Mouse Prostaglandin E synthase 2 (Ptges2), partial

Recombinant Mouse Prostaglandin E synthase 2 (Ptges2), partial

  • 货号：
    CSB-YP018977MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP018977MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP018977MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP018977MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP018977MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    Ptges2; Gbf1; Pges2; Prostaglandin E synthase 2; EC 5.3.99.3; GATE-binding factor 1; GBF-1; Microsomal prostaglandin E synthase 2; mPGES-2) [Cleaved into: Prostaglandin E synthase 2 truncated form]
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Isomerase that catalyzes the conversion of PGH2 into the more stable prostaglandin E2 (PGE2) (in vitro). The biological function and the GSH-dependent property of PTGES2 is still under debate. In vivo, PTGES2 could form a complex with GSH and heme and would not participate in PGE2 synthesis but would catalyze the degradation of prostaglandin E2 H2 (PGH2) to 12(S)-hydroxy-5(Z),8(E),10(E)-heptadecatrienoic acid (HHT) and malondialdehyde (MDA). May also have transactivation activity toward IFN-gamma (IFNG), possibly via an interaction with CEBPB; however, the relevance of transcription activation activity remains unclear.
  • 基因功能参考文献：
    1. mPGES-2 deletion enhanced streptozotocin (STZ)-induced liver toxicity possibly via GLUT2-mediated STZ uptake, independently of diabetes mellitus in mice. PMID: 25076362
    2. increased expression of miR-146a in bone marrow-derived mesenchymal stem cells correlated with inhibition of prostaglandin E2 synthase-2 and inhibition of prostaglandin E2 release. PMID: 23589616
    3. Transactivators GBF1 and CCAAT/enhancer-binding protein-beta physically interact to induce interferon-gamma-regulated transcription; a 37-aa long peptide derived from the GBF1 protein can associate with C/EBP-beta in an IFN-inducible manner. PMID: 15879117
    4. In the urogenital system, membrane-associated PGES-2 was highly expressed in the renal cortex, followed by the renal medulla and ovary, with lower levels in the ureter, bladder and uterus. PMID: 17064959
    5. Study suggests that in hypertensive mice, there are (a) significant microanatomic variations in the pulmonary, renal, and cardiac distribution and cellular localization of mPGES-2 and no differences in expression between genders. PMID: 17641732
    6. Analysis of the mPGES-2 deficient mouse lines does not substantiate the contention that mPGES-2 is a PGE(2) synthase. PMID: 19010439
    7. This article reviews the involvement of the PGE(2), Wnt, and BMP pathways in the development of gastric cancer. PMID: 19622104
    8. PGE(2) protects the pulmonary vasculature from remodeling during allergen-induced pulmonary inflammation PMID: 20028661

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  • 亚细胞定位：
    Golgi apparatus membrane; Single-pass membrane protein. Nucleus.; [Prostaglandin E synthase 2 truncated form]: Cytoplasm.
  • 蛋白家族：
    GST superfamily
  • 组织特异性：
    Widely expressed. Expressed in brain, heart, liver, colon and lung.
  • 数据库链接：

    KEGG: mmu:96979

    STRING: 10090.ENSMUSP00000028162

    UniGene: Mm.28048