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  4. Recombinant Mouse Programmed cell death 1 ligand 2 (Pdcd1lg2), partial

Recombinant Mouse Programmed cell death 1 ligand 2 (Pdcd1lg2), partial

  • 货号：
    CSB-YP017667MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP017667MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP017667MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP017667MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP017667MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    Pdcd1lg2; B7dc; Btdc; Cd273; Pdl2; Programmed cell death 1 ligand 2; PD-1 ligand 2; PD-L2; PDCD1 ligand 2; Programmed death ligand 2; Butyrophilin B7-DC; B7-DC; CD antigen CD273
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Involved in the costimulatory signal essential for T-cell proliferation and IFNG production in a PDCD1-independent manner. Interaction with PDCD1 inhibits T-cell proliferation by blocking cell cycle progression and cytokine production.
  • 基因功能参考文献：
    1. Data demonstrates that during Fasciola hepatica infection, the PD-L2 signaling pathway is involved in alternative macrophage polarization as well as in the control of the underlying Th1-type immune response, and concomitantly plays a key role in determining the susceptibility to this heminth infection. PMID: 27783986
    2. PD-L1 and PD-L2 in dermal fibroblasts is up-regulated by activated T cells in alopecia areata-affected skin. PMID: 28777458
    3. this study demonstrates that PD-L2 regulates the production of natural Abs against phosphorylcholine PMID: 28768724
    4. findings indicate that the PerC B cells, including PD-L1/PD-L2 B-1a cells, may suppress T cells responding to allostimulation, and thus may be optimal for donor lymphocyte injection PMID: 28570665
    5. this study shows that PD-L2 is essential for effective CD4+ T cell immunity and determines the severity of malarial infections PMID: 27533014
    6. injection of gene knockdown-dendritic cells induces intra-tumor T cell infiltration and release of inflammatory cytokines PMID: 26599163
    7. The endogenous PD-1/PD-L pathway does not limit acute experimental foreign antigen-induced circulating immune complex glomerulonephritis. PMID: 26043977
    8. PD-L1 and PD-L2 are nonredundant aspects of the natural protective response to ischemic injury and may be novel therapeutic targets for Acute kidney injury. PMID: 25404361
    9. long-term use of indomethacin leads to poor prognoses through promoting the expression of PD-1 and PD-L2. PMID: 26162855
    10. demonstrate that subcategorizing memory B cells on the basis of their expression of CD80 and PD-L2 PMID: 24880458
    11. In vivo T cell activation induces the formation of CD209(+) PDL-2(+) dendritic cells. PMID: 24098455
    12. Blockade of PD-L2 and RGMb interaction prevented the development of respiratory tolerance PMID: 24752301
    13. Endogenous IL-21, therefore, has potent and specific effects on mucosal antiviral responses, assisting viral clearance, regulating pulmonary T- and B-cell responses, and inhibiting IL-17 production. PMID: 23149662
    14. Host PD-L1 is dominant over PD-L2 expression in regulating graft-versus-host disease lethality. PMID: 24030385
    15. Programmed cell death ligand 2 regulates TH9 differentiation and induction of chronic airway hyperreactivity. PMID: 23174661
    16. PD-L2 induction on dendritic cells exposed to Mycobacterium avium downregulates BCG-specific T cell response. PMID: 21147037
    17. results demonstrate that PD-L2 is involved in the arginase/inducible nitric oxide synthase balance during Trypanosoma cruzi infection PMID: 21303364
    18. Deficiencies of B7-H1 and B7-DC abrogated oral tolerance, accompanied by enhanced antigen-specific CD4(+) T-cell response and IgG(1) production. PMID: 20574047
    19. PD-L2(-/-) mice show increased airway hyperreactivity and enhanced production of IL-4 by iNKT cells PMID: 19741598
    20. PD-L2 expression is regulated by two different promoters that function in a lineage-specific manner, with the B-1-specific promoter being constitutively active as a result of Oct1 and Oct2 binding. PMID: 19710692
    21. B7-DC plays a critical inhibitory role in controlling the exaggerated T helper type (Th)2 responses induced by Nippostrongylus brasiliensis infection. PMID: 20065112
    22. B7-1 and B7-2, but not PD-L1 and PD-L2, on IL-10-treated DC and DC-derived exosomes play a critical role in immunosuppressive functions of both DC and exosomes. PMID: 19757438
    23. The expression of PD-1/PD-L1, L2 is upregulated in EAH and regulated by IFN-gamma and IL-4. PD-1 system may play an important role in the pathogenesis of autoimmune hepatitis. PMID: 19781375
    24. expression patterns of PD-L1 and PD-L2 with the cells of lymphohematopoietic tissues exclusively expressing the former PMID: 12161284
    25. B7-DC expression is inducible on macrophages and dendritic cells upon stimulation with IFN-gamma, GM-CSF, or IL-4. PMID: 12421930
    26. most normal tissues and cardiac isografts had minimal expression of PD-1, PD-L1, or PD-L2, but intragraft induction of all three molecules occurred during development of cardiac allograft rejection PMID: 12444166
    27. molecular modeling and functional mapping of B7-H1 and B7-DC uncouple costimulatory function from PD-1 interaction PMID: 12719480
    28. Data show that expression of B7DC on the tumor cells promotes CD8 T cell-mediated rejection of tumor cells, at both the induction and effector phase of antitumor immunity. PMID: 12810690
    29. Cooperative B7-1/2 (CD80/CD86) and B7-DC costimulation of CD4+ T cells independent of the PD-1 receptor. PMID: 12847135
    30. A unique role is suggested for B7-DC in the regulation of asthmatic response through an IFN-gamma-dependent, but programmed death-1(PD-1)-independent, mechanism. PMID: 14764726
    31. T-cell-associated B7-H1 and B7-DC negatively regulate the T-cell response via the T-T interaction PMID: 16236366
    32. PD-L1 and PD-L2 differentially regulate the susceptibility and chronic progression of EAE in a strain-specific manner PMID: 16517716
    33. Results demonstrate that PDL2 negatively regulates T cells in immune responses and plays an essential role in immune tolerance. PMID: 16864790
    34. Blockade of PD-1 or B7-H1, but not B7-DC, at the time of self-antigen encounter mitigates tolerance induction and results in CD8 T-cell differentiation into functional cytolytic T lymphocyte PMID: 17392506
    35. Contributes to the poor stimulatory capacity of immature dendritic cells, which have a hypothetically inhibitory bias. PMID: 17412283
    36. extend the range of known PD-L2 expression to B cells and show that B1 cells identified by this marker express a specific repertoire associated with anti-bacterial immunity PMID: 17683117
    37. PD-1/PD-L pathway has an important role in downregulating proatherogenic T cell response and atherosclerosis by limiting APC-dependent T cell activation. PMID: 17853943
    38. PD-L1 and PD-L2 function differently in regulating alloreactive T-cell activation in vivo, and PD-L2 is predominant in this graft vs host disease model in limiting alloreactive CD8(+) T-cell proliferation. PMID: 17924994
    39. The PD-L2 provide distinct negative regulatory checkpoints poised to suppress autoimmune renal disease. PMID: 18025191
    40. PD-1/PD-L pathway has a key role in the regulation of antifungal immunity PMID: 18268348
    41. analysis of the crystal structure of the complex between programmed death-1 (PD-1) and its ligand PD-L2 PMID: 18641123
    42. suggesting a protective role for C5a through regulation of B7 molecule expression on plasmacytoid dendritic cells PMID: 19342693
    43. Blockade of B7-H1 or B7-DC induces an anti-tumor effect in a mouse pancreatic cancer model. PMID: 19724910

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  • 亚细胞定位：
    Cell membrane; Single-pass type I membrane protein.
  • 蛋白家族：
    Immunoglobulin superfamily, BTN/MOG family
  • 组织特异性：
    Expressed in immature and mature bone marrow-derived dendritic cells and splenic dendritic cells. Highly expressed in placenta, liver and weakly expressed in heart, spleen, lymph nodes and thymus. Also expressed in some tumor cell lines of lymphoid origin
  • 数据库链接：

    KEGG: mmu:58205

    STRING: 10090.ENSMUSP00000108195

    UniGene: Mm.116737