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  4. Recombinant Mouse Platelet glycoprotein 4 (Cd36), partial

Recombinant Mouse Platelet glycoprotein 4 (Cd36), partial

  • 货号：
    CSB-YP600143MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP600143MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP600143MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP600143MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP600143MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    Cd36Platelet glycoprotein 4; Glycoprotein IIIb; GPIIIB; PAS IV; PAS-4; Platelet glycoprotein IV; GPIV; CD antigen CD36
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Multifunctional glycoprotein that acts as receptor for a broad range of ligands. Ligands can be of proteinaceous nature like thrombospondin, fibronectin, collagen or amyloid-beta as well as of lipidic nature such as oxidized low-density lipoprotein (oxLDL), anionic phospholipids, long-chain fatty acids and bacterial diacylated lipopeptides. They are generally multivalent and can therefore engage multiple receptors simultaneously, the resulting formation of CD36 clusters initiates signal transduction and internalization of receptor-ligand complexes. The dependency on coreceptor signaling is strongly ligand specific. Cellular responses to these ligands are involved in angiogenesis, inflammatory response, fatty acid metabolism, taste and dietary fat processing in the intestine (Probable). Binds long-chain fatty acids and facilitates their transport into cells, thus participating in muscle lipid utilization, adipose energy storage, and gut fat absorption. In the small intestine, plays a role in proximal absorption of dietary fatty acid and cholesterol for optimal chylomicron formation, possibly through the activation of MAPK1/3 (ERK1/2) signaling pathway. Involved in oral fat perception and preferences. Detection into the tongue of long-chain fatty acids leads to a rapid and sustained rise in flux and protein content of pancreatobiliary secretions. In taste receptor cells, mediates the induction of an increase in intracellular calcium levels by long-chain fatty acids, leading to the activation of the gustatory neurons in the nucleus of the solitary tract. Important factor in both ventromedial hypothalamus neuronal sensing of long-chain fatty acid and the regulation of energy and glucose homeostasis. Receptor for thombospondins, THBS1 and THBS2, mediating their antiangiogenic effects. As a coreceptor for TLR4:TLR6 heterodimer, promotes inflammation in monocytes/macrophages. Upon ligand binding, such as oxLDL or amyloid-beta 42, interacts with the heterodimer TLR4:TLR6, the complex is internalized and triggers inflammatory response, leading to NF-kappa-B-dependent production of CXCL1, CXCL2 and CCL9 cytokines, via MYD88 signaling pathway, and CCL5 cytokine, via TICAM1 signaling pathway, as well as IL1B secretion, through the priming and activation of the NLRP3 inflammasome. Selective and nonredundant sensor of microbial diacylated lipopeptide that signal via TLR2:TLR6 heterodimer, this cluster triggers signaling from the cell surface, leading to the NF-kappa-B-dependent production of TNF, via MYD88 signaling pathway and subsequently is targeted to the Golgi in a lipid-raft dependent pathway.; (Microbial infection) Acts as an accessory receptor for M.tuberculosis lipoprotein LprA, in conjunction with coreceptors TLR2 and TLR1; the lipoprotein acts as an agonist to modulate antigen presenting cell functions in response to the pathogen. Directly mediates cytoadherence of Plasmodium falciparum parasitized erythrocytes and the internalization of particles independently of TLR signaling. Mediates uptake of E.coli and S.aureus but has no effect on uptake of M.fortuitum.
  • 基因功能参考文献：
    1. normal and defective embryos lacking SR-B1 have divergent expression profiles PMID: 30290792
    2. SIRT1 upregulation protects against liver injury induced by a HFD through inhibiting CD36 and the NF-kappaB pathway in mouse Kupffer cells. PMID: 29845302
    3. Cd36 deficiency led to reduced expression of phagocytosis receptor Mertk and nuclear receptor Nr4a1 in cardiac macrophages, the latter previously shown to be required for phagocyte survival. PMID: 28860151
    4. CD36 plays an important proinflammatory role in ConA-induced liver injury by promoting hepatic inflammation and mediating the proapoptotic effect of chemokine CXCL10, and therefore, may be a potential therapeutic target for immune-mediated hepatitis PMID: 29220536
    5. both paracrine and endocrine effects of adiponectin may contribute to reduced reactive oxygen species generation and apoptosis after MI/R, in a CD36-dependent manner PMID: 29018142
    6. CD36 is important for muscle glucose metabolism and optimal insulin responsiveness. PMID: 29748289
    7. Overexpressing STAMP2 attenuates adipose tissue angiogenesis and insulin resistance in diabetic ApoE(-/-) /LDLR(-/-) mouse via a PPARgamma/CD36 pathway. PMID: 28631352
    8. This study demonstrated the CD36 deletion in mice (CD36(-/-) mice) resulted in an attenuated progression of chronic epilepsy compared with wild-type (WT) mice. PMID: 29111364
    9. TMP upregulated the protein stability of ABCA1 without affecting ABCG1. Accordingly, TMP regulated the expression of SR-A, CD36, ABCA1 and ABCG1 in aortas of ApoE-/- mice, which resembled the findings observed in macrophages. PMID: 28791414
    10. atherogenic condition could activate eosinophils and modulate the phenotype of macrophages (from M2 to M1 phenotype), in part, through the CD36 receptor signaling PMID: 28623741
    11. CD36 plays a role in the perception of specific odour-active volatile compounds in the nasal cavity. PMID: 28637956
    12. CD36 plays an important role in modifying gallstone susceptibility in mice PMID: 28634191
    13. CD36 is essential for endurance improvement, changes in whole-body metabolism, and efficient peroxisome-proliferator activated receptors (PPAR)-related transcriptional responses in the muscle with exercise training. PMID: 28526781
    14. development of obesity-related chronic kidney disease via CD36 in mice PMID: 28536108
    15. The low magnitude of opsonin-independent phagocytosis of Escherichia coli and unimpaired phagocytosis of Staphylococcus aureus in SR-A- or CD36-deficient macrophages indicate that the defect in this process might not be responsible for the reported impaired bacteria clearance in mice deficient in these receptors. PMID: 27826145
    16. Results show that CD36 deficiency promoted the development of nonalcoholic steatohepatitis by facilitating the transcription of MCP-1 in hepatocytes due to the reduction of ROS and nuclear HDAC2. These results provide evidence that decreased ROS production by CD36 deletion was also harmful for livers. The fine balance of CD36 plays an important role in maintaining balances of hepatic ROS and nuclear HDAC2. PMID: 27967209
    17. Coexpression of the Olfr287 in olfactory sensory neurons with CD36 suggests that only a specific set of olfactory receptors may be coexpressed with CD36 in these neurons. PMID: 27145700
    18. Neither the lack of CD36 nor the deletion of the smac gene from Plasmodium chabaudi significantly impacted on acute-stage pathology or parasite sequestration. By contrast, in the absence of ICAM-1, infected animals experience less anaemia and weight loss, reduced parasite accumulation in both spleen and liver and higher peripheral blood parasitaemia during acute stage malaria. PMID: 28468674
    19. stimulation of the ERK/NF-kappaB pathway by Porphyromonas gingivalis led to transactivation of the CD36 promoters, thereby upregulating CD36 expression in the infected macrophages. PMID: 27234131
    20. Nonclassical monocytes crawl/patrol along the vessel wall during early atherogenesis via CD36 signaling. PMID: 28935758
    21. In conclusion, we demonstrated in this study for the first time that periodontal CD36 expression was associated with MetS-exacerbated periodontitis. We also demonstrated that CD36 is involved in the enhancement by palmitate of LPS-induced inflammatory molecule expression in macrophages. PMID: 27753178
    22. Results show that CD36 and Platelet-Activating Factor Receptor are important mediators of house dust mites (HDM) allergy development and that inhibiting HDM engagement with phosphorylcholine receptors in the lung protects against allergic airway disease. PMID: 28667161
    23. These findings suggest that atherogenic conditions critically regulate platelet CD36 signaling by increasing superoxide radical anion and hydrogen peroxide through a mechanism that promotes activation of MAPK ERK5. PMID: 28336528
    24. the results obtained from Ccr2(-/-), Cd36(-/-), and CD36 bone marrow chimeric mice showed that sequestration in the absence of CD36-mediated phagocytic clearance by monocytes leads to exaggerated lung pathologic features. PMID: 26516185
    25. In addition, purinergic receptor P2X, ligand-gated ion channel 7 (P2X7) was downregulated in CD36-knockdown 3T3-L1 cells, suggesting that the suppression of CD36 attenuates adipogenesis via the P2X7 pathway in 3T3-L1 cells. PMID: 28712872
    26. Data suggest that the transmembrane domains of Tlr4 and Tlr6 have essential roles in Tlr4/Tlr6/Cd36 receptor multimerization and activation; disruption of receptor multimerization (here, using a recombinant peptide fragment from Tlr4 transmembrane domain) reduces secretion of proinflammatory mediators from microglia and ultimately rescues neurons from death. PMID: 28655763
    27. cardiomyocyte-specific CD36 ablation in the absence of elevated circulating fatty acid levels accelerates the progression of pressure overload-induced cardiac hypertrophy to systolic heart failure PMID: 28062415
    28. CD36 regulates NADPH oxidase activity and mediates FA-induced oxidative stress PMID: 27195707
    29. Hyperhomocysteinemia activates the AHR-CD36 pathway by increasing hepatic LXA4 content, which results in hepatic steatosis. PMID: 26928949
    30. CD36 plays an important role in hydrogen peroxide-mediated lung injury. PMID: 27913425
    31. Lysophosphatidic acid/PKD-1 signaling leads to nuclear accumulation of histone deacetylase 7, where it interacts with forkhead box protein O1 to suppress endothelial CD36 transcription and mediates silencing of antiangiogenic switch, resulting in proangiogenic and proarteriogenic reprogramming. PMID: 27013613
    32. CD36 functions as a protective metabolic sensor in the liver under lipid overload and metabolic stress. PMID: 27528620
    33. a novel mechanism of leptin-induced fatty acid oxidation in muscle tissue; namely, this process is dependent on the activation of AMPK to induce the translocation of FAT/CD36 to the plasma membrane, thereby stimulating fatty acid uptake. PMID: 27827305
    34. the results show that CD36 plays a significant role in controlling parasite burden by contributing to proinflammatory cytokine responses by DCs and natural killer cells, Th1 development, phagocytic receptor expression, and phagocytic activity. PMID: 28416609
    35. The stroke-induced CD36 mRNA level correlated with increased expression of lysosomal acid lipase, an M2 macrophage marker. Functionally, higher CD36 expression in monocyte-derived macrophages is correlated with higher phagocytic indices in post-ischemic brain immune cells. PMID: 27646002
    36. These data demonstrate that CD36 enhances lipopolysaccharide responsiveness to Klebsialle pneumoniae to increase downstream cytokine production and macrophage phagocytosis that is independent of polysaccharide capsular antigen. PMID: 27683817
    37. We demonstrated that varenicline upregulates expression of LOX-1 and CD36 significantly through alpha7 nAChR, thereby promoting oxLDL uptake in macrophages. PMID: 28202387
    38. study demonstrates that tamoxifen inhibits CD36 expression and cellular oxLDL accumulation by inactivating the PPARgamma signaling pathway, and the inhibition of macrophage CD36 expression can be attributed to the anti-atherogenic properties of tamoxifen. PMID: 27358406
    39. Progesterone can play dual pathophysiological roles by activating PPARgamma expression, in which progesterone increases macrophage CD36 expression and oxLDL accumulation, a negative effect on atherosclerosis, and enhances the PPARgamma-CD36 pathway in adipose tissue and skeletal muscle, a protective effect on pregnancy. PMID: 27226602
    40. miR-133a regulates TR4 expression in ox-LDL-induced mouse RAW 264.7 macrophages PMID: 27109382
    41. Visfatin upregulated CD36 and SRA expression and downregulated ABCA1 and ABCG1 expression, subsequently increased ox-LDL uptake and decreased cholesterol efflux, and finally promoted foam cell formation via the PI3K- and ERK-dependent pathways. PMID: 26536203
    42. data reveal a new cell-signaling role for MMP-9 through CD36 degradation to regulate macrophage phagocytosis and neutrophil apoptosis. PMID: 26578544
    43. by co-operating with CD14 in both R- and S-LPS loading onto TLR4/MD-2, CD36 can enhance the sensitivity of tissue-resident macrophages in detecting infections by Gram-negative bacteria. PMID: 27073833
    44. Results demonstrated that Mipu1 regulated CD36 expression and lipid uptake, and identified a functional Mipu1-response element (MRE) in the mouse CD36 promoter during oxLDL stimulation in RAW264.7 cells. PMID: 26383633
    45. Identify a CD36-mediated mechanistic pathway through which extracellular vesicles inhibit microvascular endothelial cell migration and tube formation. PMID: 26821945
    46. In High fat diet-fed animals, disruption of hepatic Cd36 protects against associated systemic inflammation and insulin resistance. PMID: 26650570
    47. data suggest that macrophage CD36 is a critical regulator of oxidative fibrogenic signaling and that CD36-mediated phagocytosis of apoptotic cells may serve as an important pathway in the progression of fibrosis. PMID: 26092500
    48. CD36 plays a role in the mammalian olfaction. PMID: 26186589
    49. CD36 mediated fatty acid-induced podocyte apoptosis via oxidative stress might participate in the process of diabetic nephropathy. PMID: 26000608
    50. Porphyromonas gingivalis infection in the oral cavity can lead to significant TLR2-CD36/SR-B2 dependent IL1ss release. PMID: 25938460

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  • 亚细胞定位：
    Cell membrane; Multi-pass membrane protein. Apical cell membrane. Membrane raft. Golgi apparatus.
  • 蛋白家族：
    CD36 family
  • 组织特异性：
    Expressed in the apical side of lingual taste bud cells of the circumvallate papillae. Highly expressed in the intestine on the luminal surface of enterocytes. In small intestines expression levels follow a steep decreasing gradient from proximal to dista
  • 数据库链接：

    KEGG: mmu:12491

    STRING: 10090.ENSMUSP00000080974

    UniGene: Mm.18628