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  4. Recombinant Mouse Pancreatic lipase-related protein 2 (Pnliprp2)

Recombinant Mouse Pancreatic lipase-related protein 2 (Pnliprp2)

  • 货号：
    CSB-YP018264MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP018264MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP018264MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP018264MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP018264MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Pnliprp2
  • Uniprot No.：
  • 别名：
    Pnliprp2; Plrp2; Pancreatic lipase-related protein 2; PL-RP2; EC 3.1.1.26; EC 3.1.1.3; Cytotoxic T-lymphocyte lipase; Galactolipase
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    17-468
  • 氨基酸序列
    KEVC YGHLGCFSND KPWAGMIQRP SKIFPWSPED IDTRFLLYTN ENPNNYQIIS ATDPATINAS NFQLDRKTRF IIHGFIDKGE EGWLLDMCKK MFQVEKVNCI CVDWKRGSRT EYTQASYNTR VLGAEIAFLV QVLSTEMGYS PENVHLIPHS LGSHVAGEAG RRLEGHVGRI TGLDPAEPCF QGLPEEVRLD PSDAMFVDVI HTDSAPIIPY LGFGMSQKVG HLDFFPNGGK EIPGCQKNIL STIVDINGIW EGTRNFAACN HLRSYKYYAS SILNPDGFLG YPCSSYEKFQ HNDCFPSPEQ GCPKMGHYAD QFEGKTATVE QTFFLNTADT GNFTRWRYKV SVTLSGPKKL SGYILVALYG CNANSKQYEV FKGSLQPEAR YIRDIDVDVN VGEIQKVKFL WNNKVINLFR PTMGASQITL QRAKDGKEFN FCTSNTVHED VLQSLYPC
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Lipase that primarily hydrolyzes triglycerides and galactosylglycerides. In neonates, may play a major role in pancreatic digestion of dietary fats such as milk fat globules enriched in long-chain triglycerides. Hydrolyzes short-, medium- and long-chain fatty acyls in triglycerides without apparent positional specificity. Can completely deacylate triacylglycerols. When the liver matures and bile salt synthesis increases, likely functions mainly as a galactolipase and monoacylglycerol lipase. Hydrolyzes monogalactosyldiglycerols (MGDG) and digalactosyldiacylglycerols (DGDG) present in a plant-based diet, releasing long-chain polyunsaturated fatty acids. Hydrolyzes medium- and long-chain fatty acyls in galactolipids. May act together with LIPF to hydrolyze partially digested triglycerides. Hydrolyzes long-chain monoglycerides with high efficiency. In cytotoxic T cells, contributes to perforin-dependent cell lysis, but is unlikely to mediate direct cytotoxicity. Also has low phospholipase activity. In neurons, required for the localization of the phospholipid 1-oleoyl-2-palmitoyl-PC (OPPC) to neurite tips through acyl chain remodeling of membrane phospholipids. The resulting OPPC-rich lipid membrane domain recruits the t-SNARE protein STX4 by selectively interacting with the STX4 transmembrane domain and this promotes surface expression of the dopamine transporter SLC6A3/DAT at neurite tips by facilitating fusion of SLC6A3-containing transport vesicles with the plasma membrane.
  • 基因功能参考文献：
    1. Data suggest that the conditional expression of mPlrp2 and mClps is involved in the hydrolysis of retinyl esters in the mouse liver. PMID: 21339507
    2. study concluded that pancreatic lipase-related protein 2 is the major colipase-dependent lipase in the pancreas of newborn mice PMID: 14704305
    3. BSSL and PLRP2 responsible for fat digestion as long as milk is the main food. Milk-borne BSSL is able to compensate for a slower ontogeny of pancreatic BSSL expression in the mouse. PMID: 17805199
    4. PLRP2 induction by IL-4 in cytotoxic T-lymphocytes (CTLs) and reevaluation of the negative effects of its gene ablation on cytotoxicity are reported. PMID: 19451396
  • 亚细胞定位：
    Secreted. Zymogen granule membrane; Peripheral membrane protein. Cell projection, neuron projection.
  • 蛋白家族：
    AB hydrolase superfamily, Lipase family
  • 组织特异性：
    Expressed in acinar cells of pancreas (at protein level).
  • 数据库链接：

    KEGG: mmu:18947

    STRING: 10090.ENSMUSP00000026081

    UniGene: Mm.212333