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  4. Recombinant Mouse One cut domain family member 2 (Onecut2)

Recombinant Mouse One cut domain family member 2 (Onecut2)

  • 货号：
    CSB-YP744312MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP744312MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP744312MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP744312MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP744312MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Onecut2
  • Uniprot No.：
  • 别名：
    Onecut2; Oc2; One cut domain family member 2; One cut homeobox 2; Transcription factor ONECUT-2; OC-2
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-505
  • 氨基酸序列
    MKAAYTAYRC LTKDLEGCAM NPELTMESLG TLHGPVGGGS GGGGGGGGGG GGGGPGHEQE LLASPSPHHA GRGAAGSLRG PPPPTAHQEL GTAAAAAAAA SRSAMVTSMA SILDGSDYRP ELSIPLHHAM SMSCDSSPPG MGMSNTYTTL TPLQPLPPIS TVSDKFHHPH PHHHPHHHHH HHHHHQRLSG NVSGSFTLMR DERGLPSMNN LYSPYKEMPS MSQSLSPLAA TPLGNGLGGL HNAQQSLPNY GPPGHDKMLS PNFDAHHTAM LTRGEQHLSR GLGTPPAAMM SHLNGLHHPG HTQSHGPVLA PSRERPPSSS SGSQVATSGQ LEEINTKEVA QRITAELKRY SIPQAIFAQR VLCRSQGTLS DLLRNPKPWS KLKSGRETFR RMWKWLQEPE FQRMSALRLA ACKRKEQEPN KDRNNSQKKS RLVFTDLQRR TLFAIFKENK RPSKEMQITI SQQLGLELTT VSNFFMNARR RSLEKWQDDL GTGGSSSTSS TCTKA
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Transcriptional activator. Activates the transcription of a number of liver genes such as HNF3B.
  • 基因功能参考文献：
    1. Onecut1 and Onecut2 have roles in operating downstream of Pax6 to regulate horizontal cell development PMID: 25794677
    2. similar to Onecut1, Onecut2 is also necessary for the formation of normal numbers of horizontal cells in the developing retina. PMID: 25313862
    3. identified downstream genes of Oc1 and Oc2 that shows that the onecut factors suppress the production of the late cell type, rods, indicating that the two factors contribute to the competence of retinal progenitor cells for early retinal cell fates PMID: 25228773
    4. OC-2 is required for development of the Locus Coeruleus and of the mesencephalic trigeminal nucleus. PMID: 22534286
    5. Onecut2 and Onecut1 have similar expression patterns throughout retinal development and may also function in the genesis and maintenance of retinal horizontal cells. PMID: 21830221
    6. Data show that Onecut-2/Onecut-3 double knockout is a perinatal lethal. PMID: 20354101
    7. These results indicate that the expression of HNF-6 and OC-2 regulators of liver and pancreas development is modulated by miR-495 and miR-218. PMID: 19913497
    8. Our data unveil a complex and dynamic expression profile of the OC proteins in spinal MN, which suggests that these factors may participate in regulatory networks that control different steps of motor neuron development. PMID: 19800948
    9. We describe here the cloning of mouse (m) OC-2 and its expression pattern in the mouse embryo. PMID: 12971999
    10. although hepatocyte nuclear factor (HNF)6/onecut(OC)-2 and perhaps HNF1 activate the P2 promoter in the embryo, increasing HNF4alpha1 expression throughout development causes a switch to essentially exclusive P1 promoter activity in the adult liver PMID: 15159395
    11. Onecut transcription factor Onecut2 inhibits activin/TGF beta signaling in the parenchyma, and this allows normal hepatocyte differentiation. PMID: 16103213
    12. HNF-6 and OC-2 play partially redundant roles in developing pancreas, antero-posterior patterning of the gut and in enteroendocrine differentiation. PMID: 17400205
    13. Data suggest that the Onecut transcription factors HNF-6/OC-1 and OC-2 regulate early liver expansion by controlling hepatoblast migration. PMID: 17936262

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  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    CUT homeobox family
  • 数据库链接：

    KEGG: mmu:225631

    STRING: 10090.ENSMUSP00000110798

    UniGene: Mm.234723