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  4. Recombinant Mouse Oncostatin-M-specific receptor subunit beta (Osmr), partial

Recombinant Mouse Oncostatin-M-specific receptor subunit beta (Osmr), partial

  • 中文名称：
    小鼠Osmr重组蛋白
  • 货号：
    CSB-YP017261MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Osmr重组蛋白
  • 货号：
    CSB-EP017261MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Osmr重组蛋白
  • 货号：
    CSB-EP017261MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Osmr重组蛋白
  • 货号：
    CSB-BP017261MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Osmr重组蛋白
  • 货号：
    CSB-MP017261MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    Osmr; Osmrb; Oncostatin-M-specific receptor subunit beta; Interleukin-31 receptor subunit beta; IL-31 receptor subunit beta; IL-31R subunit beta; IL-31R-beta; IL-31RB
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Associates with IL31RA to form the IL31 receptor. Binds IL31 to activate STAT3 and possibly STAT1 and STAT5. Capable of transducing OSM-specific signaling events.
  • 基因功能参考文献：
    1. OSMR-beta deficiency in macrophages improved high-fat diet-induced atherogenesis and plaque vulnerability PMID: 28258089
    2. Osmr expression in healthy mouse colon tissue was detected in endothelial and stromal cells. In agreement with observations of increased OSMR expression in inflamed colon tissue, the number of cells expressing Osmr was markedly increased in the lamina propria of mice with colitis. PMID: 28368383
    3. defects in OSM signaling promote the deterioration of high-fat diet-induced obesity and related metabolic disorders PMID: 24695736
    4. Data indicate that OSM receptor beta subunit-deficient (OSMRbeta(-/-)) mice exhibited phenotypic changes in adipose tissue macrophages (ATMs) to M1, increased proinflammatory cytokines in the adipose tissue, and systemic insulin resistance. PMID: 23760275
    5. These data indicate that the transient RANKL induction by intermittent PTH administration, which is associated with its anabolic action, is changed to a prolonged induction in OSMR-deficient osteoblasts, resulting in bone destruction. PMID: 22190112
    6. Bone formation can be stimulated independently of bone resorption and provide new insights into OSMR signaling. PMID: 20051625
    7. Expression of oncostatin M receptor beta in a specific subset of nociceptive sensory neurons. PMID: 12814362
    8. regulates hematopoiesis in vivo by stimulating stromal cells as well as hematopoietic progenitors, in particular megakaryocytic and erythrocytic progenitors. PMID: 12855584
    9. Mice deficient in OSM receptor showed impaired liver regeneration with persistent parenchymal necrosis after carbon tetrachloride exposure. Recovery of liver mass from partial hepatectomy was also significantly delayed in OSMR(-/-) mice. PMID: 14999682
    10. the up-regulation of p-STAT3 and p-CREB may be induced possibly through OSMR in inflammation PMID: 15893881
    11. These findings suggest that IL-31 and OSM may thus have redundant functions in the development of OSMRbeta-expressing neurons. PMID: 16926070
    12. Bone marrow progenitor cells involved in injured liver regeneration express OSMRB. PMID: 17379762
    13. IL-6 and Oncostatin M individually affect the profile of leukocyte trafficking PMID: 18641356

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  • 亚细胞定位：
    Membrane; Single-pass type I membrane protein.
  • 蛋白家族：
    Type I cytokine receptor family, Type 2 subfamily
  • 组织特异性：
    Widely expressed. Expressed at highest levels in the lung, heart, thymus and spleen. Expressed in dorsal root ganglia.
  • 数据库链接：

    KEGG: mmu:18414

    STRING: 10090.ENSMUSP00000022746

    UniGene: Mm.10760