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  4. Recombinant Mouse Oligodendrocyte transcription factor 3 (Olig3)

Recombinant Mouse Oligodendrocyte transcription factor 3 (Olig3)

  • 货号：
    CSB-YP016330MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP016330MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP016330MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP016330MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP016330MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Olig3
  • Uniprot No.：
  • 别名：
    Olig3; Bhlhb7; Oligodendrocyte transcription factor 3; Oligo3; Class B basic helix-loop-helix protein 7; bHLHb7; Oligodendrocyte-specific bHLH transcription factor 3
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-273
  • 氨基酸序列
    MNSDSSSVSS RASSPDMDEM YLRDHHHRHH HHHQESRLNS VSSTQGDMVQ KMPGESLSRA GAKAAGESSK YKIKKQLSEQ DLQQLRLKIN GRERKRMHDL NLAMDGLREV MPYAHGPSVR KLSKIATLLL ARNYILMLTS SLEEMKRLVG EIYGGHHSAF HCGTVGHSAG HPAHAANAVH PVHPILGGAL SSGNASSPLS ATSLPTIGTI RPPHSLLKAP STPPALQLGS GFQHWAGLPC PCTICQMPPP PHLSALSTAN MARLSAESKD LLK
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    May determine the distinct specification program of class A neurons in the dorsal part of the spinal cord and suppress specification of class B neurons.
  • 基因功能参考文献：
    1. Olig3 plays different roles in regulating the development of dorsal and ventral spinal cord PMID: 25350849
    2. Olig3 is specifically and transiently expressed in different types of progenitors of embryonic central nervous system and then disappears in the course of development PMID: 11960707
    3. Olig3 expression distinguishes the two major classes of progenitors in the dorsal spinal cord and determines the distinct specification program of class A neurons. PMID: 15769945
    4. dorsal Olig3 cells contribute to dorsal midline cells and commissural interneurons at intermediate and ventral levels PMID: 16145668
    5. Wnt/beta-catenin signals act upstream of Olig3 in the specification of dI2 and dI3 neurons. PMID: 17150208
    6. Olig3 is specifically expressed in dorsal progenitor 1 domains of neural progenitor cells in the caudal hindbrain and regulates the fates of these neural progenitor cells. PMID: 18829970
    7. The fate of class A neurons was not correctly determined in Olig3 mutants. As a consequence, the nucleus of the solitary tract did not form, and precerebellar nuclei, such as the inferior olivary nucleus, were absent or small. PMID: 19088088

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  • 亚细胞定位：
    Nucleus.
  • 组织特异性：
    Weakly expressed, mainly in non-neural tissues.
  • 数据库链接：

    KEGG: mmu:94222

    UniGene: Mm.156946