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  4. Recombinant Mouse Nucleus accumbens-associated protein 1 (Nacc1)

Recombinant Mouse Nucleus accumbens-associated protein 1 (Nacc1)

  • 中文名称：
    小鼠Nacc1重组蛋白
  • 货号：
    CSB-YP745889MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Nacc1重组蛋白
  • 货号：
    CSB-EP745889MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Nacc1重组蛋白
  • 货号：
    CSB-EP745889MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Nacc1重组蛋白
  • 货号：
    CSB-BP745889MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Nacc1重组蛋白
  • 货号：
    CSB-MP745889MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Nacc1
  • Uniprot No.：
  • 别名：
    Nacc1; Btbd14b; Nac1; Nucleus accumbens-associated protein 1; NAC-1; BTB/POZ domain-containing protein 14B
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-514
  • 氨基酸序列
    MAQTLQMEIP NFGNSILECL NEQRLQGLYC DVSVVVKGHA FKAHRAVLAA SSSYFRDLFN SSRSAVVELP AAVQPQSFQQ ILTFCYTGRL SMNMGDQFLL IYTAGFLQIQ EIMEKGTEFF LKVSSPSCDS QGLHPEEAPS SEPQSPVAQT LGWPACSTPL PLVSRVKTEQ ELDSVQCTPM AKRLWDSSQK EAGGSGGNNG SRKMAKFSTP DLALNRMPQP LSMATATAAV AVVAVGGCVS GPSMSERTSP GTSSAYTSDS PSSYHNEEDE EEDAGEEGTD EQYRQICNMY TMYSMLNVGQ TAEKVEALPE QVVLESRSRI RVRQDLASLP AELINQIGNR CHPKLYDEGD PSEKLELVTG TNVYITRAQL MNCHVSAGTR HKVLLRRLLA SFFDRNTLAN SCGTGIRSST NDPRRKPLDS RVLHAVKYYC QNFAPNFKES EMNAIAADMC TNARRVVRKS WLPKTKPLHL VEGDNYSSFI SDTCKIEPDM MSMEHSFETA SHDGEAGPSA EVLQ
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Functions as a transcriptional repressor. Seems to function as a transcriptional corepressor in neuronal cells through recruitment of HDAC3 and HDAC4. Contributes to tumor progression, and tumor cell proliferation and survival. This may be mediated at least in part through repressing transcriptional activity of GADD45GIP1. Required for recruiting the proteasome from the nucleus to the cytoplasm and dendritic spines. Involved in the acute behavioral and neurological responses to cocaine and amphetamines.
  • 基因功能参考文献：
    1. Nac1 overexpression promotes ESC proliferation and delays ESC differentiation in the absence of leukemia inhibitory factor (LIF). Furthermore, we demonstrated that Nac1 directly binds to the c-Myc promoter and regulates c-Myc transcription. PMID: 28548937
    2. a sub-network of four factors, Nac1, Oct4, Tcf3, and Sox2, regulates mouse embryonic stem cell differentiation into the alternative mesendodermal and neuroectodermal fates. PMID: 26832399
    3. NAC1 participates in the motility and differentiation of developing chondrocytes and cartilaginous tissues, and its expression is necessary to maintain normal axial patterning of murine skeleton. PMID: 23922682
    4. The mouse Nac1 gene consist of six exons, with exon 2 containing an alternative splice donor, providing a molecular explanation of the splice variants observed in mouse and rat. PMID: 14521994
    5. these data indicate involvement of NAC1 in the acute behavioral and neurochemical responses to psychomotor stimulants PMID: 17945361
    6. Nanog interacts with Nac1 through WNAAP to regulate the cell cycle of stem cells via the ERas/phosphatidylinositol 3-kinase/Akt pathway, but not pluripotency PMID: 19366700

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  • 亚细胞定位：
    Nucleus. Cytoplasm.
  • 组织特异性：
    Ubiquitously expressed with higher expression in the brain, kidney and liver, and at lower levels in heart, lung and testes.
  • 数据库链接：

    KEGG: mmu:66830

    STRING: 10090.ENSMUSP00000001975

    UniGene: Mm.289698