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  4. Recombinant Mouse Nostrin (Nostrin)

Recombinant Mouse Nostrin (Nostrin)

  • 货号：
    CSB-YP761531MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP761531MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP761531MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP761531MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP761531MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Nostrin
  • Uniprot No.：
  • 别名：
    Nostrin; Daip2; Nostrin; Disabled homolog 2-interacting protein 2; Dab2-interacting protein 2; Nitric oxide synthase trafficker; eNOS-trafficking inducer
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-506
  • 氨基酸序列
    MRDPLTDCSY NKVYKSLKEF AQHGDNFCKQ ITSVLQQRAN LEISYAKGLQ KLAVRLSKAL QSTKKNCLST AWAWASESMK SAADLHQKLG KAIELEAIKP THQVLSMQEK KRKSLDNEVE KTANLVINNW NQQIKAKKKL MMSTKKHEAL FHLVESSKQS LTQKEKQKLL NKLKKSTEKL EKEDESYYQK NMAGYSTRLK WESTLENCYK SMLELEKERI QLLCNNLNQY SQHISLFGQT LTTCHTQIHC AISKVDVEKD IQALMEETAI LSIENKSELL LADYFEEDPK NPMDKERRKS LLKPKLGRLQ RDIEKASRDK EGLERKLKAL ASSSSFSDAK SQKDMETLMD ENSLKLDLLQ ANSYKLSSVL ADLEQRPKPC HPCSTCIFKW KEKEHSHTYV KISRPLLTKR LEKAESKAPA GGQNNPSSSP SGSTVSQASK HLCKALYTFQ ARQDDELNLE KGDIVTVHEK KEEGWWFGSL KGKRGHFPAA YVEELPPKAG NTATQA
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Multivalent adapter protein which may decrease NOS3 activity by inducing its translocation away from the plasma membrane.
  • 基因功能参考文献：
    1. the SH3 domain of NOSTRIN is involved in the NOSTRIN-TRAF6 interaction and is required for NOSTRIN-induced down-regulation of endothelial cell proteins PMID: 28235804
    2. NOSTRIN is crucial for the localization and function of the muscarinic M3 receptor at the plasma membrane in the aorta. PMID: 26169369
    3. mouse NOSTRIN acts as a transcriptional repressor by binding to the cis-element through its bZIP motif. PMID: 24361894
    4. NOSTRIN participates in FGF signal transduction and vascular development. PMID: 22751148
    5. Results reveal an elegant mechanism of eNOS regulation by PECAM-1 through signal transducers and activators of transcription 3-mediated transcriptional control of NOSTRIN. PMID: 21183735
    6. shares 82% identity with human NOSTRIN; functions in a different fashion from NOSTRIN and its function may be concerted with that of disabled 2(disabled 2 interacting protein 2) PMID: 15596140
    7. The disabled 2 interacting protein 2 represses the expression of its own gene, via a feedback mechanism which involves binding to the promoter region. PMID: 16171775

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  • 亚细胞定位：
    Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasmic vesicle. Cytoplasm, cytoskeleton. Cytoplasm. Nucleus.
  • 数据库链接：

    KEGG: mmu:329416

    STRING: 10090.ENSMUSP00000036923

    UniGene: Mm.90047