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  4. Recombinant Mouse Nicotinamide riboside kinase 2 (Itgb1bp3)

Recombinant Mouse Nicotinamide riboside kinase 2 (Itgb1bp3)

  • 中文名称：
    小鼠Nmrk2重组蛋白
  • 货号：
    CSB-YP866699MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Nmrk2重组蛋白
  • 货号：
    CSB-EP866699MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Nmrk2重组蛋白
  • 货号：
    CSB-EP866699MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Nmrk2重组蛋白
  • 货号：
    CSB-BP866699MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Nmrk2重组蛋白
  • 货号：
    CSB-MP866699MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Nmrk2
  • Uniprot No.：
  • 别名：
    Nmrk2; Itgb1bp3; Nrk2; Nicotinamide riboside kinase 2; NRK 2; NmR-K 2; EC 2.7.1.22; Integrin beta-1-binding protein 3; Muscle integrin-binding protein; MIBP; Nicotinic acid riboside kinase 2; EC 2.7.1.173; Ribosylnicotinamide kinase 2; RNK 2; Ribosylnicotinic acid kinase 2
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-195
  • 氨基酸序列
    MKLIIGIGGV TNGGKTTLTN SLLKALPNCC VIHQDDFFKP QDQIAVGEDG FKQWDVLESL DMETMLSTVQ AWVKDPHKFA RAHGVSLQSG ASDTHVLLLE GFLLYSYRPL VDLYSQRYFL TVPYEECKRR RRSRTYMVPD PPGLFDGHVW PMYQKYRREM EQDGVEVVYL DGMKSPEGLF HQVLEDIQNR LLNTS
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Catalyzes the phosphorylation of nicotinamide riboside (NR) and nicotinic acid riboside (NaR) to form nicotinamide mononucleotide (NMN) and nicotinic acid mononucleotide (NaMN). Reduces laminin matrix deposition and cell adhesion to laminin, but not to fibronectin. Involved in the regulation of PXN at the protein level and of PXN tyrosine phosphorylation. May play a role in the regulation of terminal myogenesis.
  • 基因功能参考文献：
    1. Nrk2 knockout mice develop normally and show subtle alterations to their NAD+ metabolome and expression of related genes in skeletal muscle. NRK2 KO myotubes revealed redundancy in the NRK1/2 dependent metabolism of nicotinamide riboside to NAD+. PMID: 28752046
    2. functions in the control of myogenic differentiation by regulating alpha7beta1 integrin-mediated cell interactions with laminin matrix and intracellular signaling through paxillin. PMID: 12941630
  • 蛋白家族：
    Uridine kinase family, NRK subfamily
  • 组织特异性：
    Expressed in skeletal muscle (at protein level).
  • 数据库链接：

    KEGG: mmu:69564

    STRING: 10090.ENSMUSP00000005069

    UniGene: Mm.437211