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  4. Recombinant Mouse Neutrophil collagenase (Mmp8)

Recombinant Mouse Neutrophil collagenase (Mmp8)

  • 中文名称：
    小鼠Mmp8重组蛋白
  • 货号：
    CSB-YP014678MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Mmp8重组蛋白
  • 货号：
    CSB-EP014678MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Mmp8重组蛋白
  • 货号：
    CSB-EP014678MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Mmp8重组蛋白
  • 货号：
    CSB-BP014678MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Mmp8重组蛋白
  • 货号：
    CSB-MP014678MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Mmp8
  • Uniprot No.：
  • 别名：
    Mmp8; Neutrophil collagenase; EC 3.4.24.34; Collagenase 2; Matrix metalloproteinase-8; MMP-8
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full length protein
  • 表达区域：
    101-465
  • 氨基酸序列
    LTPGSPKWTH TNLTYRIINH TPQLSRAEVK TAIEKAFHVW SVASPLTFTE ILQGEADINI AFVSRDHGDN SPFDGPNGIL AHAFQPGQGI GGDAHFDSEE TWTQDSKNYN LFLVAAHEFG HSLGLSHSTD PGALMYPNYA YREPSTYSLP QDDINGIQTI YGPSDNPIQP TGPSTPKACD PHLRFDATTT LRGEIYFFKD KYFWRRHPQL RTVDLNFISL FWPFLPNGLQ AAYEDFDRDL VFLFKGRQYW ALSGYDLQQG YPRDISNYGF PRSVQAIDAA VSYNGKTYFF INNQCWRYDN QRRSMDPGYP KSIPSMFPGV NCRVDAVFLQ DSFFLFFSGP QYFAFNFVSH RVTRVARSNL WLNCS
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Can degrade fibrillar type I, II, and III collagens. May play a role in the degradation of collagen fibers during uterine involution.
  • 基因功能参考文献：
    1. Suggest that Ang-(1-7) plays an important role in protecting against atherosclerosis via counter-regulation of Ang II-induced MMP-8. PMID: 28283184
    2. MMP8 plays an important role in intestinal I/R injury through mechanisms involving increased inflammation and loss of claudin-3 PMID: 27435263
    3. These results suggest that some of the anti-inflammatory effects of Dexamethasone are mediated through increased MMP-8 expression. PMID: 26923552
    4. These results suggest a novel pathogenetic role of MMP8 and implicate modulation of its activity as a tractable strategy for therapies against cerebral ischemia. PMID: 25421209
    5. Fusion peptide inhibitors of MMP-8/-9 prevent endotoxic shock if administered within a strict time window. PMID: 26111477
    6. the loss of MMP-8 likely has pleiotropic effects on innate immunity and angiogenesis that are reflected in changes in the protease web. PMID: 25848906
    7. A previously unknown role of MMP8 in M2-macrophage polarization by cleaving fibromodulin and therefore increasing the bioavailability of TGF-beta. PMID: 26092731
    8. MMP-8-deficient mice had significantly lower serum triglyceride (TG) levels (P = 0.003) and larger HDL particles compared with wild-type (WT) mice. However, no differences were observed in the apoA-I levels. PMID: 25550459
    9. These results demonstrate that MMP-8 critically mediates microglial activation by modulating TNF-alpha activity, which may explain neuroinflammation in septic mouse brain. PMID: 25049354
    10. MMP8 enhances vascular smooth muscle cell proliferation via an ADAM10, N-cadherin, and beta-catenin-mediated pathway and plays an important role in neointima formation. PMID: 24158518
    11. Suggest that MMP8 plays an important role in angiogenesis in vitro and in vivo. PMID: 23512982
    12. MMP8 plays an important role in stem cell migration and their recruitment into atherosclerotic lesions. PMID: 23071158
    13. These results show that MMP-8 can modulate the levels of S100A8 and S100A9 and its absence promotes the lung inflammatory response during endotoxemia. PMID: 22768176
    14. Mmp-8 has a protective role in arthritis PMID: 21190566
    15. MMP-8 is not essential for neutrophil migration in arthritis and likely other autoimmune diseases. Rather, MMP-8 is important for normal rates of neutrophil apoptosis and hence regulates cell clearance. PMID: 21120997
    16. MMP-8 promotes acute inflammation after ventilation with high pressures, and its short-term inhibition could be a therapeutic goal to limit ventilator-induced lung injury. PMID: 19995943
    17. MMP-8 potently reduces the accumulation of neutrophils and macrophages in the lungs of mice with lipopolysaccharide- and bleomycin-induced acute lung injury. PMID: 20042585
    18. These results indicate that bradykinin at reperfusion triggers its cardioprotective signalling pathway through MMP-8-dependent transactivation of the EGFR. PMID: 19583703
    19. In vitro, fewer MMP-8(-/-) PMNs migrated thru 3D cross-linked collagen gels than WT PMNs.This was likely a result of pericollagenase activity of MMP-8, as WT PMNs expressing MMP-8 could not migrate effectively thru collagen resistant to the collagenase. PMID: 19801498
    20. immunohistochemistry of embryos between E9.5-E14.5 demonstrated MMP-8 expression in the surface ectoderm, neural crest cells and chondrocytes PMID: 11731274
    21. highly elevated expression of MMP-8 (neutrophil collagenase) mRNA and protein in experimental autoimmune encephalomyelitis; colocalizing to neutrophil infiltrates found in brain and extensively in the spinal cord submeningeal space PMID: 11985514
    22. protective role for Mmp8 in cancer and provides a genetic model to evaluate the molecular basis of gender differences in cancer susceptibility PMID: 14517555
    23. membrane-bound MMP-8 accounts for 92% of the MMP-mediated, PMN surface type I collagenase activity PMID: 15187163
    24. MMP-8 demonstrates an anti-inflammatory effect in allergic asthma and is implicated in the cascade of events leading to neutrophil apoptosis. PMID: 16081833
    25. As seen in knockout mice, MMP-8 participates in wound repair by contributing to the resolution of inflammation and opens the possibility to develop new strategies for treating wound healing defects. PMID: 17392479
    26. MMP-8 plays an important role in EAE development and propose that this enzyme may be a novel therapeutic target in human neuro-inflammatory diseases such as multiple sclerosis. PMID: 18245084
    27. Loss of matrix metalloproteinase-8 is associated with tongue carcinogenesis PMID: 18253113
    28. C-Jun-NH(2)-terminal kinase also involved in alveolo-capillary leakage and edema formation, whereas MMP8 inhibited alveolo-capillary protein leakage. PMID: 18270588
    29. MMP-8 is a tumor protective factor, which also has the ability to reduce the metastatic potential of malignant cells in both mice and human. PMID: 18413742
    30. MMP-8 regulates neutrophil migration through the extracellular matrix of the corneal stroma by generating chemotactic Pro-Gly-Pro during inflammation PMID: 18556780
    31. study concludes that matrix metalloproteinase-8 cleaves IL-13 receptor alpha2 (IL-13R alpha 2) in vitro and contributes to the solubilization of IL-13R alpha 2 in vivo PMID: 18694590
    32. MMP-8 appears to act in a protective manner inhibiting the development of bacterium-induced periodontal tissue destruction, possibly through the processing anti-inflammatory cytokines and chemokines. PMID: 19029300
    33. Data suggest that antigen challenge via the airway activates Gr-1(+) cells and consequently MMP to facilitate the recruitment of Th cells in the airway inflammatory response. PMID: 19593770
    34. Results indicate that MMP8 is an important player in atherosclerosis. PMID: 19745165

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  • 亚细胞定位：
    Cytoplasmic granule. Secreted, extracellular space, extracellular matrix. Note=Stored in intracellular granules and released during inflammatory conditions.
  • 蛋白家族：
    Peptidase M10A family
  • 组织特异性：
    Neutrophils. Expressed in uterus. Low levels in kidney and muscle.
  • 数据库链接：

    KEGG: mmu:17394

    STRING: 10090.ENSMUSP00000018765

    UniGene: Mm.16415