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  4. Recombinant Mouse Neurotensin receptor type 2 (Ntsr2), partial

Recombinant Mouse Neurotensin receptor type 2 (Ntsr2), partial

  • 货号：
    CSB-YP016138MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP016138MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP016138MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP016138MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP016138MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    Ntsr2; Neurotensin receptor type 2; NT-R-2; NTR2; Low-affinity levocabastine-sensitive neurotensin receptor; NTRL
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Receptor for the tridecapeptide neurotensin. It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system.
  • 基因功能参考文献：
    1. Molecular characterization of Thy1 expressing fear-inhibiting neurons within the basolateral amygdala identify and validate Ntsr2-expressing neurons as a putative 'Fear-Off' population. PMID: 27767183
    2. findings suggest that NTS2 regulates ethanol-induced hypnosis and ethanol consumption PMID: 21039631
    3. These data support the regulation of baseline prepulse inhibition, acoustic startle response and locomotor activity by endogenous neurotensin acting at the NT2 receptor. PMID: 20399236
    4. Ntsr2 receptor subtype is necessary for normal dopaminergic function. PMID: 20211191
    5. NTS2 receptors localized at the lumbar spinal cord participate to the disinhibition of descending pain control pathways. PMID: 20035838
    6. transcriptional regulation; maps to chromosome 12 PMID: 11687289
    7. Recycling ability depends on a single tyrosine residue PMID: 11801734
    8. increase in jump latency induced by stimulation of NTS2 receptors is mediated by the release of an endogenous opioid receptor ligand PMID: 17074405
    9. These results suggest that Ntsr2 in astrocytes and neurons may have unique function like a modulation of fear memory in the mouse brain. PMID: 17697051

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  • 亚细胞定位：
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    G-protein coupled receptor 1 family, Neurotensin receptor subfamily, NTSR2 sub-subfamily
  • 组织特异性：
    Expressed maximally in the cerebellum, hyppocampus, piriform cortex and neocortex of adult brain.
  • 数据库链接：

    KEGG: mmu:18217

    STRING: 10090.ENSMUSP00000106693

    UniGene: Mm.281715