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  4. Recombinant Mouse Neurotensin receptor type 1 (Ntsr1), partial

Recombinant Mouse Neurotensin receptor type 1 (Ntsr1), partial

  • 货号：
    CSB-YP016137MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP016137MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP016137MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP016137MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP016137MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    Ntsr1; Ntsr; Neurotensin receptor type 1; NT-R-1; NTR1
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    G-protein coupled receptor for the tridecapeptide neurotensin (NTS). Signaling is effected via G proteins that activate a phosphatidylinositol-calcium second messenger system. Signaling leads to the activation of downstream MAP kinases and protects cells against apoptosis.
  • 基因功能参考文献：
    1. The weight loss behaviors are mediated by distinct signaling pathways: Nts action via NtsR1 is essential for the anorectic effect of the lateral hypothalamic Nts circuit, but not for regulation of locomotor or drinking behavior. PMID: 29241540
    2. s identified a specific subset of VTA DA neurons that express neurotensin receptor-1 (NtsR1) and preferentially comprise mesolimbic, but not mesocortical, DA neurons. PMID: 28834751
    3. Data demonstrate that the NTR1 can modulate the methamphetamine-induced striatal neuronal apoptosis independent of body temperature regulation. Possible mechanisms of NTR1 modulating methamphetamine-induced apoptosis include the regulation of dopamine and glutamate neurotransmission in the striatum. PMID: 28130052
    4. The roles of neurotensin and its receptor NTR-1 on sperm capacitation and acrosome reaction in mice are reported. PMID: 25031361
    5. endogenous changes occur in NT and its receptors across multiple brain regions, and these likely support the emergence of some maternal behaviors. PMID: 24416154
    6. sleep traits and a relationship between Ntsr1 and anxiety and despair behaviors in knockout mice PMID: 22754041
    7. Data show that targeted disruption of the neurotensin receptor-1 (Ntsr1) gene reduces susceptibility to colon tumorigenesis. PMID: 21630261
    8. Data show that NTS1(-/-) mouse is an animal model of schizophrenia, particularly for the dysfunction of the prefrontal cortex. PMID: 20659557
    9. Ntsr1 knockout mice showed a higher freezing rate than wild type mice at both first and second exposures under the condition where a relatively weak unconditioned stimulus (footshock) PMID: 20600248
    10. Ntsr1 receptor subtype is necessary for normal dopaminergic function. PMID: 20211191
    11. These findings support the role for Ntsr1 in the mediation of the metabolic effect of xenin as well as neurotensin. PMID: 19857548
    12. Neurotensin type 1 receptor does not play a role in NT-induced analgesia, but that it is clearly implicated in thermal and feeding regulation, weight control, and NT-induced hypolocomotion. PMID: 12384239
    13. constant activation of NT1 receptor generates an oncogenic regulation PMID: 14699144
    14. NT and NTR1 are part of network activated after mucosal injuries, and NT stimulates epithelial restitution, at least in part, through a COX-2 dependent pathway. PMID: 15764810
    15. [(99m)Tc]Demotensin 6 shows a favourable preclinical profile and further testing in patients is warranted to monitor its eventual applicability as a radiotracer in the diagnostic imaging of NTS1-R-positive tumours. PMID: 17594090
    16. These results suggest that, without Ntsr1, synaptic responses from the LA to BLA pyramidal neurons undergo LTP in response to tetanus stimulation through facilitation of D(2)-like receptor-induced activation of NMDA receptors. PMID: 18354386
    17. Our data also suggest that the lack of Ntsr1 reduces sensitivity to the anorectic action of leptin, causing hyperphagia and abnormal weight gain. PMID: 18639588
    18. NTR1 does not play a major role in the control of basal thermoregulation, nociception or psychomotor stimulation in mice PMID: 19223157

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  • 亚细胞定位：
    Cell membrane; Multi-pass membrane protein. Membrane raft.
  • 蛋白家族：
    G-protein coupled receptor 1 family, Neurotensin receptor subfamily, NTSR1 sub-subfamily
  • 数据库链接：

    KEGG: mmu:18216

    STRING: 10090.ENSMUSP00000029084

    UniGene: Mm.301712