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  4. Recombinant Mouse Neurotensin/neuromedin N (Nts)

Recombinant Mouse Neurotensin/neuromedin N (Nts)

  • 货号：
    CSB-YP883989MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP883989MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP883989MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP883989MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP883989MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Nts
  • Uniprot No.：
  • 别名：
    Nts; Neurotensin/neuromedin N [Cleaved into: Large neuromedin N; NmN-125); Neuromedin N; NN; NmN); Neurotensin; NT); Tail peptide]
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    23-147
  • 氨基酸序列
    SDSEEDVR ALEADLLTNM HTSKISKASP PSWKMTLLNV CSLINNVNSP AEEAGDMHDD DLVGKRKLPL VLDGFSLEAM LTIFQLQKIC RSRAFQHWEI IQEDILDNVN DKNEKEEVIK RKIPYIL
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Neurotensin may play an endocrine or paracrine role in the regulation of fat metabolism. It causes contraction of smooth muscle.
  • 基因功能参考文献：
    1. Study reveals multiple populations of neurotensin neurons that provide direct afferents to the ventral tegmental area and which may regulate specific aspects of motivated behavior. PMID: 29478718
    2. The weight loss behaviors are mediated by distinct signaling pathways: Nts action via NtsR1 is essential for the anorectic effect of the lateral hypothalamic Nts circuit, but not for regulation of locomotor or drinking behavior. PMID: 29241540
    3. Nts-leptin receptor neurons are important neuronal hubs within the lateral hypothalamic area for hormone-mediated control of ingestive and locomotor behaviors. PMID: 28323938
    4. findings directly link NT with increased fat absorption and obesity and suggest that NT may provide a prognostic marker of future obesity and a potential target for prevention and treatment PMID: 27193687
    5. Data (including data from studies in transgenic mice) suggest Nts, glucagon-like peptide I, and peptide YY are closely co-expressed/co-secreted within enteroendocrine cells in ileum mucosa; however, Nts is stored in distinct/separate secretory granules. PMID: 26469136
    6. The roles of neurotensin and its receptor NTR-1 on sperm capacitation and acrosome reaction in mice are reported. PMID: 25031361
    7. These observations suggest the importance of neurotensin in maintaining activity of orexin neurons. PMID: 23620827
    8. a lineage of mature enteroendocrine cells have the ability to coexpress members of a group of functionally related peptides: CCK, secretin, GIP, GLP-1, PYY, and neurotensin PMID: 23064014
    9. Neurotensin knock-out mice do not differ from their wild-type or heterozygous littermates in either baseline or acute cocaine-stimulated locomotor activity. PMID: 21720755
    10. Neurotensin increases EGF expression in skin dendritic cells. PMID: 21767580
    11. NT acutely regulates D2 autoreceptor function and DA neuron excitability through PKC-mediated phosphorylation of the D2R, leading to heterologous receptor desensitization. PMID: 21233215
    12. although neurotensin neurons in the anteroventral periventricular nucleus are targets for regulation by E(2), neurotensin does not appear to play a direct role in generating the GnRH/LH surge in the mouse PMID: 19861584
    13. neurotensin has a role in chronic mitogen-activated protein kinase activation and cancer progression PMID: 14699144
    14. Data show that although brain neuromedin N mRNA distribution largely overlaps in mice and rats, species differences exist in specific brain areas, and the distribution in mice resembles that of primates more than that of rats. PMID: 15193419
    15. NT and NTR1 are part of network activated after mucosal injuries, and NT stimulates epithelial restitution, at least in part, through a COX-2 dependent pathway. PMID: 15764810
    16. Neurotensin may have a direct role in the neuroendocrine control of feeding and energy homeostasis. PMID: 16221860
    17. co-localization of peptides and enzyme in GHRH-eGFP neurons displays a sexual dimorphism at 3-month of age for NT, and at 8-month for tyrosine hydroxylase, while the total number of GHRH-eGFP neurons does not exhibit gender difference at either age. PMID: 17137749
    18. [(99m)Tc]Demotensin 6 shows a favourable preclinical profile and further testing in patients is warranted to monitor its eventual applicability as a radiotracer in the diagnostic imaging of NTS1-R-positive tumours. PMID: 17594090
    19. These results clearly indicate for the first time that NT is able to protect endocrine beta cells from external cytotoxic agents, a role well correlated with its release in the circulation after a meal. PMID: 18456542
    20. NT-mediated IL-6 expression is nuclear factor-kappaB and PKCdelta dependent PMID: 19443690

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  • 亚细胞定位：
    Secreted. Cytoplasmic vesicle, secretory vesicle.
  • 蛋白家族：
    Neurotensin family
  • 数据库链接：

    KEGG: mmu:67405

    STRING: 10090.ENSMUSP00000020040

    UniGene: Mm.64201