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  4. Recombinant Mouse Neuronal acetylcholine receptor subunit alpha-6 (Chrna6), partial

Recombinant Mouse Neuronal acetylcholine receptor subunit alpha-6 (Chrna6), partial

  • 中文名称：
    Recombinant Mouse Neuronal acetylcholine receptor subunit alpha-6(Chrna6),partial,Yeast
  • 货号：
    CSB-YP889928MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    Recombinant Mouse Neuronal acetylcholine receptor subunit alpha-6(Chrna6),partial,Yeast
  • 货号：
    CSB-EP889928MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    Recombinant Mouse Neuronal acetylcholine receptor subunit alpha-6(Chrna6),partial,Yeast
  • 货号：
    CSB-EP889928MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    Recombinant Mouse Neuronal acetylcholine receptor subunit alpha-6(Chrna6),partial,Yeast
  • 货号：
    CSB-BP889928MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    Recombinant Mouse Neuronal acetylcholine receptor subunit alpha-6(Chrna6),partial,Yeast
  • 货号：
    CSB-MP889928MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Chrna6
  • Uniprot No.：
  • 别名：
    Chrna6; Nica6; Neuronal acetylcholine receptor subunit alpha-6
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.
  • 基因功能参考文献：
    1. study provides evidence that alpha6beta2 nAChRs are involved in locomotor activity as well as ethanol and saccharin consumption in adolescent animals PMID: 28457669
    2. Using behavioral and cellular measures of alpha6 * nAChR function, study demonstrated that the ventral tegmental area is a key site of action for nicotine at alpha6 * nAChRs PMID: 26210579
    3. The present data show that alpha6beta2( *) nAChRs are key regulators of LIDs, and may be useful therapeutic targets for their management in Parkinson's disease. PMID: 25813704
    4. these data indicate that a6)nAChR do not have an impact on motor output. PMID: 23688922
    5. enhanced alpha6beta2* nAChR activity in nucleus accumbens can stimulate dopamine production PMID: 24266758
    6. Chrna6 expression decreases with death of RGCs in glaucomatous DBA/2J mice and after optic nerve crush injury, further supporting Chrna6 as a reliable RGC marker. PMID: 23002780
    7. While the Chrna6 gene did not significantly influence ethanol consumption (g/kg) or ataxia, mice lacking the alpha6 subunit took significantly longer to recover their righting reflex than WT animals PMID: 22572056
    8. The superior colliculus is responsible for transmitting short-latency salience signals to thalamus and midbrain DA neurons. these results suggest that alpha6* nAChRs may be important for nicotinic cholinergic sensitization of this pathway. PMID: 22836257
    9. beta3 subunit coexpression promotes function of alpha6*-nAChR PMID: 22315221
    10. This study highlights the precise control that the nicotinic cholinergic system exerts on DA transmission and provides further insights into the mechanisms and consequences of enhanced DA release. PMID: 22079576
    11. analysis of N-terminal extracellular domain determinants in nicotinic acetylcholine receptor (nAChR) alpha6 subunits that influence effects of wild-type or mutant beta3 subunits on function of alpha6beta2*- or alpha6beta4*-nAChR PMID: 21832048
    12. Data show that in Prkce(-/-) mice, conditioned place preference and self-administer behaviors are associated with reduced levels of alpha(6) and beta(3) nicotinic receptor subunit mRNA in the ventral midbrain and striatum. PMID: 21911393
    13. These results implicate alpha6alpha4beta2* nAChRs in cholinergic control of DA transmission PMID: 20660270

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  • 亚细胞定位：
    Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Ligand-gated ion channel (TC 1.A.9) family, Acetylcholine receptor (TC 1.A.9.1) subfamily, Alpha-6/CHRNA6 sub-subfamily
  • 数据库链接：

    KEGG: mmu:11440

    STRING: 10090.ENSMUSP00000033882

    UniGene: Mm.283137