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  4. Recombinant Mouse Neudesin (Nenf)

Recombinant Mouse Neudesin (Nenf)

  • 货号：
    CSB-YP880396MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP880396MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP880396MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP880396MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP880396MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Nenf
  • Uniprot No.：
  • 别名：
    Nenf; SpufNeudesin; Neuron-derived neurotrophic factor; Secreted protein of unknown function; SPUF protein
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    full length protein
  • 表达区域：
    31-171
  • 氨基酸序列
    GQTPRPAERG PPVRLFTEEE LARYGGEEED QPIYLAVKGV VFDVTSGKEF YGRGAPYNAL AGKDSSRGVA KMSLDPADLT HDTTGLTAKE LEALDDVFSK VYKAKYPIVG YTARRILNED GSPNLDFKPE DQPHFDIKDE F
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Acts as a neurotrophic factor in postnatal mature neurons, enhancing neuronal survival. Promotes cell proliferation and neurogenesis in undifferentiated neural pro-genitor cells at the embryonic stage and inhibits differentiation of astrocytes. Its neurotrophic activity is exerted via MAPK1/ERK2, MAPK3/ERK1 and AKT1/AKT pathways. Neurotrophic activity is enhanced by binding to heme. Acts also as an anorexigenic neurotrophic factor that contributes to energy balance.
  • 基因功能参考文献：
    1. neudesin, which may be a negative regulator of sympathetic activity, could represent a novel regulator of the development of obesity and obesity-related metabolic dysfunctions. PMID: 25955136
    2. Neuron-derived neurotrophic factor (NENF) is an important central modulator of food intake. PMID: 23576617
    3. identification of neudesin, a novel mouse secreted protein showing neurotrophic activity in primary cultured mouse neurons PMID: 15605373
    4. The present findings have revealed new potential roles of neudesin in neural cell proliferation and neuronal differentiation. PMID: 16547973
    5. Neudesin is the first extracellular heme-binding protein that shows signal transducing activity by itself. The present findings may shed new light on the function of extracellular heme-binding proteins PMID: 18056703
    6. These findings suggest that neudesin plays a critical role in the early stage of adipocyte differentiation in which C/EBPbeta induces PPARgamma and C/EBPalpha expressions, by controlling the MAPK pathway. PMID: 19351598

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  • 亚细胞定位：
    Secreted, extracellular space. Mitochondrion. Endoplasmic reticulum.
  • 蛋白家族：
    Cytochrome b5 family, MAPR subfamily
  • 组织特异性：
    In the embryo, expressed most abundantly in brain and spinal cord. Widely expressed in adult tissues including brain, heart, lung and kidney. In brain, expressed in neurons but not in glial cells. In the hypothalamus is expressed primarily in the paravent
  • 数据库链接：

    KEGG: mmu:66208

    STRING: 10090.ENSMUSP00000046311

    UniGene: Mm.46444