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  4. Recombinant Mouse Netrin receptor UNC5C (Unc5c), partial

Recombinant Mouse Netrin receptor UNC5C (Unc5c), partial

  • 中文名称：
    小鼠Unc5c重组蛋白
  • 货号：
    CSB-YP025630MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Unc5c重组蛋白
  • 货号：
    CSB-EP025630MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Unc5c重组蛋白
  • 货号：
    CSB-EP025630MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Unc5c重组蛋白
  • 货号：
    CSB-BP025630MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Unc5c重组蛋白
  • 货号：
    CSB-MP025630MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Unc5c
  • Uniprot No.：
  • 别名：
    Unc5c; Rcm; Unc5h3; Netrin receptor UNC5C; Protein unc-5 homolog 3; Protein unc-5 homolog C; Rostral cerebellar malformation protein
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. NTN1/Netrin-1 binding might cause dissociation of UNC5C from polymerized TUBB3 in microtubules and thereby lead to increased microtubule dynamics and axon repulsion. Axon repulsion in growth cones may also be caused by its association with DCC that may trigger signaling for repulsion. Might also collaborate with DSCAM in NTN1-mediated axon repulsion independently of DCC. Also involved in corticospinal tract axon guidance independently of DCC. Involved in dorsal root ganglion axon projection towards the spinal cord. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand.
  • 基因功能参考文献：
    1. UNC5C expression levels increased from the 4-cell stage to the blastocyst stage in fertilized murine embryos. Repression of UNC5C in the anterior nucleus stage inhibited development to the blastocyst stage. PMID: 26147436
    2. UNC5c expression is enriched in CA3 hippocampal neurons, but UNC5c is not expressed in microglia or perpheral blood mononuclear cells. PMID: 25419706
    3. Unc5C and DCC act downstream of Ctip2 and Satb2 and contribute to corpus callosum formation. PMID: 24739528
    4. unc5c haploinsufficiency results in diminished amphetamine-induced locomotion in male and female mice. This phenotype is identical to that produced by dcc haploinsufficiency and is observed after adolescence. PMID: 23738838
    5. this study suggested that Unc5c plays a broad role in dorsal guidance of axons in the developing hindbrain. PMID: 21307253
    6. Our results provide the first evidence that genes involved in netrin signaling are necessary for proper mammalian spinal motor axon development and trochlear axon guidance. PMID: 16723533
    7. These results support an important role for UNC5C in spinal accessory motor neuron development. PMID: 17543537
    8. repression of Unc5c expression by Rhox5 may, in part, mediate the pro-survival function of Rhox5 in the testis PMID: 18077458
    9. The netrin-1 receptor UNC5c, a proapoptotic molecule that is inhibited by RHOX5, was also regulated in vivo, and is thus a candidate to be downstream of RHOX5 in a prosurvival germ-cell pathway. PMID: 18184911

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  • 相关疾病：
    Defects in Unc5c are the cause of rostral cerebellar malformation (Rcm). Rcm is characterized by cerebellar and midbrain defects, apparently as a result of abnormal neuronal migration.
  • 亚细胞定位：
    Cell membrane; Single-pass type I membrane protein. Cell surface. Cell junction, synapse, synaptosome. Cell projection, dendrite. Cell projection, axon. Cell projection, growth cone. Cell projection, lamellipodium. Cell projection, filopodium.
  • 蛋白家族：
    Unc-5 family
  • 组织特异性：
    Expressed in cortical and cerebellar neurons, including cells of the external and internal granular layer and of the Purkinje cell layer (at protein level). Mainly expressed in regions of differentiating neurons. Highly expressed in brain and lung. Expres
  • 数据库链接：

    KEGG: mmu:22253

    STRING: 10090.ENSMUSP00000101843

    UniGene: Mm.24430