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  4. Recombinant Mouse NF-kappa-B inhibitor delta (Nfkbid)

Recombinant Mouse NF-kappa-B inhibitor delta (Nfkbid)

  • 货号：
    CSB-YP649565MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP649565MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP649565MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP649565MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP649565MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Nfkbid
  • Uniprot No.：
  • 别名：
    Nfkbid; Ikbns; NF-kappa-B inhibitor delta; I-kappa-B-delta; IkB-delta; IkappaBdelta; IkappaBNS
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-327
  • 氨基酸序列
    MEDSLDTRLY PEPSLSQVGS WRVSSLPSGS PQLPSPTGPS LETARAHILA LGPQQLLAQD EEGDTLLHLF AARGLRWAAY AAAEVLQMYR QLDIREHKGK TPLLVAAAAN QPLIVEDLLS LGAEPNATDH QGRSVLHVAA TYGLPGVLSA VFKSGIQVDL EARDFEGLTP LHTAVLALNA AMLPASVCPR MQNSQARDRL TCVQMLLQMG ASHTSQEIKS NKTILHLAVQ AANPTLVQLL LGLPRGDLRA FVNMKAHGNT ALHMAAALPP GPPQEAIVRH LLAAGADPTL RNLENEQPVH LLRPGPGPEG LRQLLKRSRT APPGLSS
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Regulates the expression of IL-2, IL-6, and other cytokines through regulation on NF-kappa-B activity. Functions in the regulation of inflammatory responses. Involved in the induction of T helper 17 cells (Th17) differentiation upon recognition of antigen by T cell antigen receptor (TCR). According to PubMed:11931770, it may also regulate TCR-induced negative selection of thymocytes.
  • 基因功能参考文献：
    1. IkappaBNS is involved in inducing Muc5ac expression in lung epithelial cells and causing AHR in HDM-induced asthma models. PMID: 27878831
    2. Deficiency of IkBNS induces atherogenesis in LDL receptor-deficient mice. PMID: 26974699
    3. Low expression of IL-6 and TNF-alpha correlates with the presence of the nuclear regulators of NF-kappaB, IkappaBNS and BCL-3, in the uterus of mice. PMID: 26442662
    4. investigated the point in the development of B-1 cells where IkappaBNS is required PMID: 25228759
    5. The unique ability of p100/IkappaBdelta to stably interact with all NF-kappaB subunits by forming kappaBsomes demonstrates its importance in sequestering NF-kappaB subunits and releasing them as dictated by specific stimuli for developmental programs. PMID: 25349408
    6. IkappaBNS is a short-lived protein of which the stability is controlled by proteasome, independent of the ubiquitylation process. The N-terminal PEST sequence in IkappaBNS was critical for the regulation of stability. PMID: 24406168
    7. A forward genetic screen reveals roles for Nfkbid, Zeb1, and Ruvbl2 in humoral immunity. PMID: 22761313
    8. IkappaBNS down-regulates TLR4 expression, NF-kappaB activity, and IL-6 production after vascular injury PMID: 22135163
    9. IkappaBNS significantly impacts the development and functions of B cells and plasma cells. PMID: 21900180
    10. blocks transcription from NF-kappa B reporters, alters NF-kappa B electrophoretic mobility shifts, and interacts with NF-kappa B proteins in thymic nuclear lysates following TCR stimulation. PMID: 11931770
    11. IkappaBNS regulates inflammatory responses by inhibiting the induction of a subset of TLR-dependent genes through modulation of NF-kappaB activity. PMID: 16413922
    12. IkappaBNS regulates production of interleukin (IL)-2 and other cytokines induced via T-cell receptor ligation. PMID: 17641034

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  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    NF-kappa-B inhibitor family
  • 组织特异性：
    Specifically expressed in spleen and at low levels in thymus. Expressed in a population of antigen-presenting dendritic cells which may act as regulators of systemic inflammatory response.
  • 数据库链接：

    KEGG: mmu:243910

    STRING: 10090.ENSMUSP00000042317

    UniGene: Mm.386878