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  4. Recombinant Mouse N-chimaerin (Chn1)

Recombinant Mouse N-chimaerin (Chn1)

  • 货号：
    CSB-YP845972MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP845972MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP845972MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP845972MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP845972MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Chn1
  • Uniprot No.：
  • 别名：
    Chn1; Arhgap2N-chimaerin; A-chimaerin; Alpha-chimerin; N-chimerin; NC; Rho GTPase-activating protein 2
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    2-459
  • 氨基酸序列
    ALTLFDTDE YRPPVWKSYL YQLQQEAPHP RRVTCTCEVE NRPKYYGREY HGMISREETD QLLSVAEGSY LIRESQRQPG TYTLALRFGS QTRNFRLYYD GKHFVGEKRF ESIHDLVTDG LITLYIETKA AEYIAKMTIN PIYEHIGYTT LNREPAYKQH MAVLKETHDE KEATGQDGVS EKRLTSLVRR ATLKENEQIP KYEKVHNFKV HTFRGPHWCE YCANFMWGLI AQGVKCADCG LNVHKQCSKM VPNDCKPDLK HVKKVYSCDL TTLVKAHITK RPMVVDMCIR EIESRGLNSE GLYRVSGFSD LIEDVKMAFD RDGEKADISV NMYEDINIIT GALKLYFRDL PIPLITYDAY PKFIESAKIM DPDEQLETLH EALRSLPPAH CETLRYLMAH LKRVTLHEKE NLMSAENLGI VFGPTLMRSP ELDPMAALND IRYQRLVVEL LIKNEDILF
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    GTPase-activating protein for p21-rac and a phorbol ester receptor. May play an important role in neuronal signal-transduction mechanisms. Involved in the assembly of neuronal locomotor circuits as a direct effector of EPHA4 in axon guidance.
  • 基因功能参考文献：
    1. These findings reveal a role for ephrin bidirectional signaling upstream of mutant alpha2-chimaerin in Duane retraction syndrome, which may contribute to the selective vulnerability of abducens motor neurons in this disorder PMID: 28346224
    2. This study showed that, in the mouse, hippocampal alpha2-chimaerin acts in the late postnatal stages (juvenile and adolescence) to establish both the baseline level of the dendritic spine morphology and normal contextual fear-learning ability in adulthood PMID: 26446225
    3. Developmental alpha2-chimaerin activity is important for adult cognition. PMID: 25159148
    4. Chimaerins are RhoGTPase-activating proteins that are EphA4 effectors and have been implicated in a number of processes including growth cone collapse, axon guidance, dendritic spine development and the formation of corticospinal motor circuits. PMID: 21767388
    5. These findings establish a new alpha2-chimaerin-dependent mechanism underlying neuronal migration and proper functioning of the cerebral cortex and provide insights into the pathogenesis of seizure-related neurodevelopmental disorders. PMID: 22138645
    6. Chimaerin, one of the Rho GTPase activating proteins, is transcriptionally up-regulated after exposure to neurotrophins in post-natal cerebellar neurons. PMID: 15447672
    7. lpha1-chimaerin is an activity-regulated Rho GTPase regulator that is activated by phospholipase Cbeta-coupled cell surface receptors and contributes to pruning of dendritic arbors PMID: 16446429
    8. Rac-GAP alpha-chimerin regulates motor-circuit formation as a key mediator of Efnb3 forward signaling PMID: 17719550
    9. Our results reveal an alpha-chimaerin-dependent signaling pathway downstream of EphA4, which is essential for axon guidance decisions and neuronal circuit formation in vivo. PMID: 17785182
    10. These findings identify alpha2-chimaerin as an indispensable effector for EphA4 in cortical and spinal motor circuits. PMID: 17785183

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  • 数据库链接：

    KEGG: mmu:108699

    STRING: 10090.ENSMUSP00000107655

    UniGene: Mm.257073