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  4. Recombinant Mouse Myb-related protein B (Mybl2)

Recombinant Mouse Myb-related protein B (Mybl2)

  • 货号：
    CSB-YP015264MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP015264MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP015264MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP015264MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP015264MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    Mybl2; Bmyb; Myb-related protein B; B-Myb; Myb-like protein 2
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full length protein
  • 表达区域：
    1-704
  • 氨基酸序列
    MSRRTRCEDL DELHYQDVDS DLLEQRDNRC KVKWTHEEDE QLRALVRQFG QQDWKFLASH FPNRTDQQCQ YRWLRVLNPD LVKGPWTKEE DQKVIELVKK YGTKQWTLIA KHLKGRLGKQ CRERWHNHLN PEVKKSCWTE EEDRIICEAH KVLGNRWAEI AKMLPGRTDN AVKNHWNSTI KRKVDTGGFP AESRDCKPVY LLLELEDKEQ HQGVQPVDGQ GSLVSSWPLV PSIVKEESSE EEIAIAATSA KELGHEPVPA DLGEVRTPEP PESLKREYQE FSSPETSLPY KWVVEAANLL IPAVGSSLSE ALDLIESDPD AWCDLSKFDL PEEPSTEGSV VSSPVQPQTS QQQQEEALQS SQQAATPGPS VTEYRLDGHT ISDLSRSSRG ELIPISPSTE FGGSGIGTPP SVLKRQKKRR VALSPVTENS ASLSFLDSCN SLTPKSTPVK TLPFSPSQFL NFWNKQDTLE LESPSLTSTP VCSQKVVVTT PLHRDKTPLH QKYPSSEVLP DQKYSMDNTP HTPTPFKNAL EKYGPLKPLP QTPHLEEDLK EVLRSEAGME LIIEDDMRPE KQKRKPGLRR SPIKKVRKSL ALDIMDEDGK LMSSTMPKPL SLPTSVTPSS CGFTSPGSKE GNSLLNQGFL QAKPEKVVAA QKTRSHIPTP APMTHAWKTV ACGGTKDQLF MQEKARQLLS RLKSSHTSRT LILS
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Transcription factor involved in the regulation of cell survival, proliferation, and differentiation. Transactivates the expression of the CLU gene.
  • 基因功能参考文献：
    1. Downregulation of B-myb induced senescence by upregulation of p22(phox) and activation of the ROS/p53/p21 pathway PMID: 27878894
    2. B-myb is an essential regulator of hematopoietic stem cell and myeloid progenitor cell development. PMID: 24516162
    3. MYBL2 haploinsufficiency increases susceptibility to age-related haematopoietic neoplasia. PMID: 22910183
    4. Results coupled with functional studies demonstrate that B-MYB not only controls and accelerates cell cycle progression in ESCs it contributes to fate decisions and maintenance of pluripotent stem cell identity. PMID: 22936984
    5. Our data suggest that B-Myb is required as a pioneer factor to enable FoxM1 binding to G2/M gene promoters and explains how these transcription factors may collaborate to induce mitosis. PMID: 22513242
    6. Mybl2 upregulation induces fast growth and progression of premalignant and malignant liver, through cell cycle deregulation and activation of genes and pathways related to tumor progression. PMID: 21419759
    7. The transcription factor B-Myb is maintained in an inhibited state in target cells through its interaction with the nuclear corepressors N-CoR and SMRT. PMID: 11997503
    8. Results describe the characterization of a corepressor site (downstream repression site (DRS)) required for transcriptional regulation of the B-myb (MybL2 gene) promoter. PMID: 12147683
    9. B-Myb repressor function is regulated by cyclin A phosphorylation and sequences within the C-terminal domain. PMID: 12673206
    10. B-Myb has a role in regulation of c-Myc expression by cytosolic phospholipase A2 PMID: 14769798
    11. B-Myb represses SMC elastin gene expression and cyclin A plays a role in the developmental regulation of elastin gene expression in the aorta PMID: 15615710
    12. Mip/LIN-9 is required for the expression of B-Myb, and both proteins collaborate in the control of the cell cycle progression via the regulation of S phase and cyclin A, cyclin B, and CDK1 PMID: 17098733
    13. The repressor complex that Mip/LIN-9 forms with p107 takes functional precedence over the transcriptional activation linked to the Mip/LIN-9 and B-Myb interaction. PMID: 17563750
    14. proliferation-inhibiting A(2B)AR is itself an inducible receptor regulated by B-Myb. PMID: 17979185
    15. Lin-9 and B-Myb were both required for transcription of G(2)/M genes such as Cyclin B1 and Survivin. PMID: 19252525

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  • 亚细胞定位：
    Nucleus.
  • 数据库链接：

    KEGG: mmu:17865

    STRING: 10090.ENSMUSP00000018005

    UniGene: Mm.4594