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  4. Recombinant Mouse Monocarboxylate transporter 2 (Slc16a7), partial

Recombinant Mouse Monocarboxylate transporter 2 (Slc16a7), partial

  • 货号：
    CSB-YP021414MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP021414MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP021414MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP021414MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP021414MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Slc16a7
  • Uniprot No.：
  • 别名：
    Slc16a7; Mct2; Monocarboxylate transporter 2; MCT 2; Solute carrier family 16 member 7
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Proton-coupled monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate. Functions as high-affinity pyruvate transporter.
  • 基因功能参考文献：
    1. Adipocytes promote malignant growth of mammary gland tumors with MCT2 expression via beta-hydroxybutyrate. PMID: 28281525
    2. These results suggest that basigin has a functional role as a binding partner with MCT2 in testicular and epididymal spermatozoa. PMID: 26208397
    3. This study demonstrated that MCT2 was up regulation in ipsilateral site of brain afeter cerebral ischemia. PMID: 26751713
    4. MCT2 distribution coupled with lactate uptake by hypothalamic neurons suggests that hypothalamic neurons control food intake using lactate to reflect changes in glucose levels. PMID: 23638108
    5. Glucose-deprived cleavage stage embryos, undergo oxidative stress and exhibit elevated ROS, which in turn upregulates PPARA, catalase and SLC16A7 in a classical peroxisomal proliferation response. PMID: 19531609
    6. These results demonstrate that MCT2 expression can be upregulated together with other key postsynaptic proteins in vivo under conditions related to synaptic plasticity PMID: 21736920
    7. changes in MCT2 expression could participate in the process of synaptic plasticity induced by BDNF PMID: 19794395
    8. data provide convincing evidence that MCT2 represents a major neuronal monocarboxylate transporter in the adult mouse brain PMID: 11973431
    9. In mouse cortical neurons MCT2 is the major monocarboxylate transporter; its expression is correlated with synaptic development. PMID: 12836157
    10. Regulation of expression of MCT1 and MCT2 was investigated in mouse cortical neurons; neither noradrenaline, dibutyryl cAMP nor forskolin affected MCT2 mRNA expression PMID: 12950455
    11. Noradrenaline induces an increase in neuronal MCT2 protein expression by a mechanism involving stimulation of phosphoinositide 3-kinase/Akt and translational activation via the mTOR/S6 kinase pathway. PMID: 17394554
    12. Transfection assays demonstrate that three regions contained a functional promoter and that the in vitro, cell type-specific activities of these promoters are consistent with tissue-specific expression. PMID: 17911380
    13. Unique roles for slc16a7 in monocarboxylate transport and pH regulation during preimplantation development. PMID: 18385447
    14. MCT2 is linked to AMPA receptor GluR2/3 subunits and undergoes a similar translocation process in neurons upon activation PMID: 19453627

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  • 亚细胞定位：
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Major facilitator superfamily, Monocarboxylate porter (TC 2.A.1.13) family
  • 组织特异性：
    Detected in testis and in spermatozoa (at protein level).
  • 数据库链接：

    KEGG: mmu:20503

    STRING: 10090.ENSMUSP00000065433

    UniGene: Mm.29161