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  4. Recombinant Mouse Mast cell carboxypeptidase A (Cpa3)

Recombinant Mouse Mast cell carboxypeptidase A (Cpa3)

  • 货号：
    CSB-YP005877MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP005877MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP005877MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP005877MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP005877MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    Cpa3Mast cell carboxypeptidase A; MC-CPA; EC 3.4.17.1; Carboxypeptidase A3
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    110-417
  • 氨基酸序列
    I AGRHSYAKYN DWDKIVSWTE KMLEKHPEMV SRIKIGSTVE DNPLYVLKIG KKDGERKAIF MDCGIHAREW ISPAFCQWFV YQATKSYGKN KIMTKLLDRM NFYVLPVFNV DGYIWSWTQD RMWRKNRSRN QNSTCIGTDL NRNFDVSWDS SPNTNKPCLN VYRGPAPESE KETKAVTNFI RSHLNSIKAY ITFHSYSQML LIPYGYTFKL PPNHQDLLKV ARIATDALST RYETRYIYGP IASTIYKTSG SSLDWVYDLG IKHTFAFELR DKGKSGFLLP ESRIKPTCKE TMLSVKFIAK YILKNTS
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 基因功能参考文献：
    1. The goal of the current study was to compare bone repair in normal wild type and Cpa3Cre/+ mice, which lack mast cells in the absence of any other hematopoietic or non- hematopoietic deficiencies. Mast cells appear in healing bone of wild type mice but not Cpa3Cre/+ mice, beginning 14 days after surgery. Re-vascularization of repair tissue and deposition of mineralized bone was delayed and dis-organised in Cpa3Cre/+ mice PMID: 28350850
    2. Mast cells in experimental arthritis contained high levels of mMC-CPA mRNA, and also lacked the exopeptidase. PMID: 28193842
    3. Data suggest that carboxypeptidase A3 (Cpa3)-Cre; myeloid cell leukemia sequence 1 (Mcl-1)(fl/fl) mice may be useful in analyzing the roles of mast cells and basophils in health and disease. PMID: 22001390
    4. mast cell chymase and CPA have key roles in both the generation and degradation of Ang II PMID: 15173164
    5. cathepsin E is located in mast-cell secretory granules in complex with heparin proteoglycans, and has a role in the processing of procarboxypeptidase A into active protease PMID: 15860733
    6. Mc-cpa plays a crucial role for the generation of phenotypically mature mast cells. PMID: 15988029

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  • 亚细胞定位：
    Cytoplasmic vesicle, secretory vesicle. Note=Secretory granules.
  • 蛋白家族：
    Peptidase M14 family
  • 数据库链接：

    KEGG: mmu:12873

    STRING: 10090.ENSMUSP00000001921

    UniGene: Mm.1135