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  4. Recombinant Mouse Lysosomal Pro-X carboxypeptidase (Prcp)

Recombinant Mouse Lysosomal Pro-X carboxypeptidase (Prcp)

  • 货号：
    CSB-YP763098MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP763098MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP763098MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP763098MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP763098MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    Prcp; Lysosomal Pro-X carboxypeptidase; EC 3.4.16.2; Proline carboxypeptidase; Prolylcarboxypeptidase; PRCP
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    44-491
  • 氨基酸序列
    RKYSVLY FEQKVDHFGF ADMRTFKQRY LVADKHWQRN GGSILFYTGN EGDIVWFCNN TGFMWDVAEE LKAMLVFAEH RYYGESLPFG QDSFKDSQHL NFLTSEQALA DFAELIRHLE KTIPGAQGQP VIAIGGSYGG MLAAWFRMKY PHIVVGALAA SAPIWQLDGM VPCGEFMKIV TNDFRKSGPY CSESIRKSWN VIDKLSGSGS GLQSLTNILH LCSPLTSEKI PTLKGWIAET WVNLAMVNYP YACNFLQPLP AWPIKEVCQY LKNPNVSDTV LLQNIFQALS VYYNYSGQAA CLNISQTTTS SLGSMGWSFQ ACTEMVMPFC TNGIDDMFEP FLWDLEKYSN DCFNQWGVKP RPHWMTTMYG GKNISSHSNI IFSNGELDPW SGGGVTRDIT DTLVAINIHD GAHHLDLRAH NAFDPSSVLL SRLLEVKHMK KWILDFYSNI Q
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Cleaves C-terminal amino acids linked to proline in peptides such as angiotensin II, III and des-Arg9-bradykinin. This cleavage occurs at acidic pH, but enzymatic activity is retained with some substrates at neutral pH.
  • 基因功能参考文献：
    1. Prolylcarboxypeptidase (PRCP) converts AngII to Ang (1-7) but only at an acidic pH. Global PRCP deficiency causes heart and kidney alterations and a moderate rise in BP. PRCP is abundant in the kidney collecting tubules, where the prevailing pH is low. In collecting tubules, PRCP deficiency could result in impaired AngII degradation. Increased AngII at this nephron site stimulates Na reabsorption and increases BP. PMID: 28160049
    2. activity and expression in plasma and lung tissue stays unaffected in lung ischemia-reperfusion injury PMID: 27437782
    3. This study demonistrated that PRCP gene is broadly expressed in the brain. PMID: 24161824
    4. PRCP regulates cell growth, angiogenesis, and the response to vascular injury PMID: 23744584
    5. PRCP is an important regulator of energy and glucose homeostasis since its deletion significantly improves metabolic parameters in mice exposed to both standard chow diet and high-fat diet PMID: 22454290
    6. analysis of non-benzimidazole and brain-penetrant prolylcarboxypeptidase inhibitors PMID: 22079761
    7. This study showed that PRCP mutant mice have a significant decrease in fat mass, although an increase in lean mass was also observed; reduced leptin levels and increased energy expenditure were also found. PMID: 22202165
    8. Murine prolylcarboxypeptidase depletion induces vascular dysfunction with hypertension and faster arterial thrombosis. PMID: 21297000
    9. PRCP is an important component of melanocortin signaling and weight maintenance via control of active alpha-MSH1-13 levels. PMID: 19620781

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  • 亚细胞定位：
    Lysosome.
  • 蛋白家族：
    Peptidase S28 family
  • 数据库链接：

    KEGG: mmu:72461

    STRING: 10090.ENSMUSP00000075429

    UniGene: Mm.389969