Your Good Partner in Biology Research

  1. 首页
  2. 蛋白
  3. 重组蛋白
  4. Recombinant Mouse Lymphatic vessel endothelial hyaluronic acid receptor 1 (Lyve1), partial

Recombinant Mouse Lymphatic vessel endothelial hyaluronic acid receptor 1 (Lyve1), partial

  • 中文名称：
    小鼠Lyve1重组蛋白
  • 货号：
    CSB-YP805268MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Lyve1重组蛋白
  • 货号：
    CSB-EP805268MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Lyve1重组蛋白
  • 货号：
    CSB-EP805268MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Lyve1重组蛋白
  • 货号：
    CSB-BP805268MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Lyve1重组蛋白
  • 货号：
    CSB-MP805268MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Lyve1
  • Uniprot No.：
  • 别名：
    Lyve1; Crsbp1; Xlkd1Lymphatic vessel endothelial hyaluronic acid receptor 1; LYVE-1; Cell surface retention sequence-binding protein 1; CRSBP-1; Extracellular link domain-containing protein 1
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Ligand-specific transporter trafficking between intracellular organelles (TGN) and the plasma membrane. Plays a role in autocrine regulation of cell growth mediated by growth regulators containing cell surface retention sequence binding (CRS). May act as a hyaluronan (HA) transporter, either mediating its uptake for catabolism within lymphatic endothelial cells themselves, or its transport into the lumen of afferent lymphatic vessels for subsequent re-uptake and degradation in lymph nodes.
  • 基因功能参考文献：
    1. Study in metastatic MDA-MB-231 xenograft models shows that LYVE-1 is involved in primary tumor formation and metastasis, and it may be a promising molecular target for cancer therapy. PMID: 30058195
    2. lymphatic vessel endothelial hyaluronan receptor-1 (LYVE1) is identified as a marker of yolk sac (YS) endothelium and definitive hematopoietic stem and progenitor cells. PMID: 27880904
    3. Dendritic cells (DCs) docked to the basolateral surface of lymphatic vessels and transited to the lumen through hyaluronan-mediated interactions with the lymph-specific endothelial receptor LYVE-1. Targeted deletion of the gene Lyve1, antibody blockade or depletion of the DC hyaluronan coat not only delayed lymphatic trafficking of dermal DCs but also blunted their capacity to prime CD8(+) T cell responses in LNs. PMID: 28504698
    4. the LYVE-1-expressing cells might be involved in the uptake of hyaluronan and other waste products as well as foreign particles circulating in the blood and lymph while participating in the subsequent degradation in relay with adjacent macrophage populations. PMID: 27356606
    5. Immunostaining analyses in VEGF-A transgenic skin suggested that the ectodomain shedding of LYVE-1 occurred in lymphatic vessels undergoing chronic inflammation. These results indicate that the ectodomain shedding of LYVE-1 might be involved in promoting pathological lymphangiogenesis. PMID: 26966180
    6. Endogenous hyaluronan on the surface of macrophages can engage LYVE-1, facilitating their adhesion and transit across lymphatic endothelium. PMID: 26823460
    7. MT1-MMP directly cleaves LYVE-1 on lymphatic endothelial cells to inhibit LYVE-1-mediated lymphangiogenic responses and restrains the production of VEGF-C. PMID: 26926389
    8. Data (including data from studies in knockout mice) suggest Lyve1 mediates adhesion of group A Streptococci (GAS) to lymphatic vesicular endothelium via capsular hyaluronan; this appears to be critical factor for lymphatic trafficking of GAS in vivo. PMID: 26352587
    9. Data show that the expression of lymphatic vessel endothelial hyaluronan receptor 1 (LYVE 1) was similar with vascular endothelial growth factor C (VEGF-C), but its peak appeared 1-2 d later than that of VEGF-C. PMID: 25270205
    10. LMW-HA may play a critical role in the processes required for lymphangiogenesis through interactions with its receptor LYVE-1 and triggering intracellular signal cascades. PMID: 24667755
    11. Studied the specific targeting property of lymphatic vessel endothelial hyaluronan receptor-1 binding polyethylene glycol-coated ultrasmall superparamagnetic iron oxide (LYVE-1-PEG-USPIO) nanoparticles to mouse lymphatic endothelial cells. PMID: 23818783
    12. Reelin-deficient mice showed abnormal collecting lymphatic vessels, characterized by a reduced number of SMCs, abnormal expression of lymphatic capillary marker lymphatic vessel endothelial hyaluronan receptor 1 (LYVE-1), and impaired function PMID: 22665518
    13. report intact CD31(+) corneal lymphatic capillary endothelial cells that do not express LYVE-1. The number of LYVE-1(-) gaps initially increased until 8 wk of age but was significantly reduced in aged mice. PMID: 22090317
    14. Adrenomedullin and SB431542 enhance the induction of LYVE-1-positive endothelial cells during late phase differentiation. PMID: 21782867
    15. CRSBP-1 ligands induce disruption of VE-cadherin-mediated intercellular adhesion and opening of intercellular junctions in lymphatic endothelial cell. PMID: 21444752
    16. Expression of lymphatic endothelium-specific hyaluronan receptor LYVE-1 in the developing mouse kidney PMID: 21181199
    17. the expression of lymphatic vessel endothelial hyaluronan receptor-1 is dramatically reduced early in Lama2-deficient muscle pathogenesis PMID: 20876525
    18. This study provides the first evidence that the hyaloid vascular system contains a LYVE-1(+) cellular component in both physiological and pathologic conditions. PMID: 20688736
    19. LYVE-1 is not exclusive to the lymph vessels PMID: 11719431
    20. Lymphatic endothelial cells in the intestine of T1a/podoplanin -/- mice had high levels of Lyve-1 protein in the luminal and abluminal plasma membranes. PMID: 12853470
    21. Ang signaling regulates LYVE-1-positive lymphatic vessel formation through Tie2 PMID: 15705793
    22. The CRSBP-1 ligands PDGF-BB and HA enhance interstitial-lymphatic flow in wild-type mice but not in CRSBP-1-null animals PMID: 17070806
    23. LYVE-1 is not obligatory for normal lymphatic development and function and suggest either the existence of compensatory receptors or a role more specific than that previously envisaged. PMID: 17101772
    24. The occurrence of LYVE-1-expressing lymphatic compartments and the alteration of CCL21 expression in the lymphatics may be involved in defective thymocyte differentiation and migration, and play a significant role in insulitic and diabetic processes. PMID: 17176958
    25. The recruitment, infiltration and accumulation of bone marrow-derived LYVE-1-expressing macrophages are crucial for the formation of the dense vascular network in adipose tissue. PMID: 17272806
    26. describe the development of hepatic sinusoids in mice based on the expression of hyaluronan receptors Stab2 and Lyve-1 PMID: 17626278
    27. analysis of inflammation-induced uptake and degradation of the lymphatic endothelial hyaluronan receptor LYVE-1 PMID: 17884820
    28. Data show that LYVE-1 is expressed on blood vessels of the yolk sac during embryogenesis, on intra-embryonic arterial and venous endothelium at early embryonic stages, and on endothelial cells of the lung and endocardium throughout embryogenesis. PMID: 18570254
    29. Our findings support an important role of CD44 expressed by CD4(+) and CD8(+) for development of ileitis mediated by TNF overproduction. PMID: 18854186
    30. complexity in the regulation of LYVE-1 function and raise the possibility that this receptor, like CD44, may become active after appropriate unmasking in vivo. PMID: 19033446
    31. These data suggest that LYVE-1 and CD44 are not required for the formation or function of lymphatics, but do not rule out a role for LYVE-1 in inflammation. PMID: 19170073
    32. Immunostaining for the specific lymphatic markers LYVE-1 revealed an extensive lymphatic vessel system in dental tissues. Unexpected cell staining for the above lymphatic markers was found in the pulp of both molars and incisors in mice. PMID: 19196316

    显示更多

    收起更多

  • 亚细胞定位：
    Membrane; Single-pass type I membrane protein. Note=Localized to the plasma membrane and in vesicles near extranuclear membranes which may represent trans-Golgi network (TGN) and endosomes/prelysosomeal compartments. Undergoes ligand-dependent internalization and recycling at the cell surface.
  • 数据库链接：

    KEGG: mmu:114332

    STRING: 10090.ENSMUSP00000033050

    UniGene: Mm.396078