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Recombinant Mouse Latexin (Lxn)

  • 中文名称：
    小鼠Lxn重组蛋白
  • 货号：
    CSB-YP013240MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Lxn重组蛋白
  • 货号：
    CSB-EP013240MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Lxn重组蛋白
  • 货号：
    CSB-EP013240MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Lxn重组蛋白
  • 货号：
    CSB-BP013240MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Lxn重组蛋白
  • 货号：
    CSB-MP013240MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Lxn
  • Uniprot No.：
  • 别名：
    LxnLatexin; Endogenous carboxypeptidase inhibitor; ECI; Tissue carboxypeptidase inhibitor; TCI
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full length protein
  • 表达区域：
    1-222
  • 氨基酸序列
    MEIPPTHYAA SRAASVAENC INYQQGTPHK LFLVQTVQQA SKEDIPGRGH KYHLKFSVEE IIQKQVTVNC TAEVLYPQMG QGSAPEVNFT FEGEIGKNPD EEDNTFYQSL MSLKRPLEAQ DIPDNFGNVS PQMKPVQHLA WVACGYVMWQ NSTEDTWYKM LKIQTVKQVQ RNDDFIELDY TILLHDIASQ EIIPWQMQVL WHPQYGTKVK HNSRLPKEGQ AE
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Hardly reversible, non-competitive, and potent inhibitor of CPA1, CPA2 and CPA4. May play a role in inflammation.
  • 基因功能参考文献：
    1. By using an Lxn knockout mouse model, this study found that Lxn inactivation in vivo led to the physiological expansion of the entire hematopoietic hierarchy. Loss of Lxn enhanced the competitive repopulation capacity and survival of hematopoietic stem cells in a cell-intrinsic manner. PMID: 28330618
    2. Rps3 knockdown increased the radiation sensitivity of FDC-P1, confirming that the mechanism of action of Lxn is mediated by Rps3 pathway. PMID: 25341047
    3. These results are consistent with a tumor suppressor role for latexin. PMID: 23028717
    4. Latexin is preferentially expressed in hematopoietic stem cells, and is co-localized with the molecules responsible for the interaction of hematopoietic stem cells with a bone marrow niche. PMID: 21567403
    5. Data indicate that AAV-mediated latexin transduction or administration of a small molecule carboxypeptidase A inhibitor significantly reduced acetone-evoked nociceptive behavior after SNI. PMID: 21572518
    6. The crystal structure of mouse latexin, solved at 1.83 A resolution, shows no structural relationship with other carboxypeptidase inhibitors. PMID: 15698574
    7. Latexin is involved in the transmission of pain, since mice lacking this protein experience reducted pain sensitivity. PMID: 16469302
    8. promoter polymorphisms between the B6 and D2 alleles may affect Lxn gene expression and consequently influence the population size of hematopoietic stem cells. PMID: 17220891
    9. These results indicate that latexin is involved in BMP-2-induced chondrocyte differentiation and plays an important role in skeletogenesis and skeletal regeneration. PMID: 19059214

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  • 亚细胞定位：
    Cytoplasm.
  • 蛋白家族：
    Protease inhibitor I47 (latexin) family
  • 组织特异性：
    Highly enriched in macrophages.
  • 数据库链接：

    KEGG: mmu:17035

    STRING: 10090.ENSMUSP00000060732

    UniGene: Mm.2632