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  4. Recombinant Mouse Krueppel-like factor 2 (Klf2)

Recombinant Mouse Krueppel-like factor 2 (Klf2)

  • 货号：
    CSB-YP713898MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP713898MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP713898MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP713898MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP713898MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    Klf2; Lklf; Krueppel-like factor 2; Lung krueppel-like factor
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-354
  • 氨基酸序列
    MALSEPILPS FATFASPCER GLQERWPRNE PEAGGTDEDL NNVLDFILSM GLDGLGAENP PEPPPQPPPP AFYYPEPGAP PPYSIPAASL GTELLRPDLD PPQGPALHGR FLLAPPGRLV KAEPPEVDGG GYGCAPGLAH GPRGLKLEGA PGATGACMRG PAGRPPPPPD TPPLSPDGPL RIPASGPRNP FPPPFGPGPS FGGPGPALHY GPPAPGAFGL FEDAAAAAAA LGLAPPATRG LLTPPSSPLE LLEAKPKRGR RSWPRKRAAT HTCSYTNCGK TYTKSSHLKA HLRTHTGEKP YHCNWEGCGW KFARSDELTR HYRKHTGHRP FQCHLCDRAF SRSDHLALHM KRHM
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Transcription factor that binds to the CACCC box in the promoter of target genes such as HBB/beta globin or NOV and activates their transcription. Might be involved in transcriptional regulation by modulating the binding of the RARA nuclear receptor to RARE DNA elements.
  • 基因功能参考文献：
    1. miRNA-92a may function through regulating KLF2. PMID: 29660330
    2. the data revealed that puerarin inhibited the monocyte adhesion in vitro and in vivo and thus reduced atherosclerotic lesions in apoE-/- mice; the protective effects were mediated by activation of ERK5/KLF2 signaling pathway. PMID: 29723698
    3. Suberanilohydroxamic acid has KLF2-dependent anti-inflammatory effects, repressing vascular inflammation and atherosclerosis. PMID: 29191808
    4. any one of Klf2, Klf4 and Klf5 was sufficient to support self-renewal of mouse embryonic stem cells, whereas the removal of all three compromised it. PMID: 29739838
    5. KLF2 induces an antiproliferative secretome, including activin A, which attenuates liver regeneration. PMID: 28348240
    6. miRNA92a targets KLF2 and PTEN signaling to promote human T follicular helper precursors in type 1 diabetes mellitus islet autoimmunity. PMID: 27791035
    7. peripheral tolerance is enhanced or diminished through modulation of Treg trafficking tosecondary lymphoid organs (SLOs), a process that can be controlled by adjusting KLF2 protein levels. PMID: 27462110
    8. KLF2 and KLF4 serve as important regulators that promote hemoglobin alpha expression in the endothelium. PMID: 28825355
    9. Mouse embryos deficient in Orai1, Klf2, or Klf4 showed a significantly reduced lymphatic density and impaired lymphatic development. PMID: 28167653
    10. this study shows that KLF2 governs the degree of dendritic cells activation and hence the intensity of proatherogenic T cell responses PMID: 27837103
    11. Transcription factor Kruppel-like factor 2 (KLF2) of the zinc finger family of DNA-binding proteins has recently emerged as a major molecular switch that controls endothelial homeostasis. PMID: 27855271
    12. our data demonstrate a protective role of KLF2 against glomerular endothelial cell injury and progression of chronic kidney disease in the model of compensatory renal hypertrophy PMID: 27317905
    13. KLF2 knockdown markedly reduced expression of miR-155 in macrophages and macrophage activation. PMID: 26406238
    14. study therefore establishes the pivotal role of Klf2 and Tfcp2l1 in mediating ESC self-renewal promoted by Wnt/beta-catenin signaling. PMID: 26321140
    15. endothelial-specific loss of Mekk3, Klf2 or Klf4 markedly prevents cerebral cavernous malformation lesion formation, reverses the increase in Rho activity, and rescues lethality PMID: 27027284
    16. knockdown of Klf2 expression in endothelial cells induced more endothelial cell injury in early diabetic nephropathy PMID: 25185079
    17. Cineromycin B inhibited adipocyte differentiation in 3T3-L1 cells mainly via upregulation of KLF2 and KLF3 mRNA expression at an early stage of the differentiation. PMID: 26092481
    18. Data reveal a novel role of HDAC5 in modulating the KLF2 transcriptional activation and eNOS expression. PMID: 25096223
    19. inhibition of leukocyte adhesion by Myocyte enhancer factor 2 C was partially mediated by induction of KLF2 PMID: 25474999
    20. KLF2 is pivotal for coordinating CD4(+) T cell differentiation through two distinct and complementary mechanisms: via control of T cell localization and by regulation of lineage-defining transcription factors. PMID: 25692701
    21. The Kruppel-like factor 2 (Klf2) is phosphorylated by Erk2 and that phospho-Klf2 is proteosomally degraded. PMID: 24905170
    22. reveals a beta1 integrin-Klf2-Egfl7-signaling pathway that is tightly regulated by cerebral cavernous malformation proteins PMID: 25625207
    23. ICOS maintains the T follicular helper cell phenotype by down-regulating Kruppel-like factor 2. PMID: 25646266
    24. Data show that Kruppel-like transcription factors KLF2 expression is decreased in mediator complex Med23 null thymocytes. PMID: 25054639
    25. Shear stress-mediated repression of endothelial cell metabolism via KLF2 and PFKFB3 controls endothelial cell phenotype. PMID: 25359860
    26. microRNAs miR-124a and miR-150 are reduced when proinflammatory mediator expression is increased in KLF2-deficient macrophages PMID: 25248747
    27. KLF2 is not only a key player in terminating pre-B cell clonal expansion but also a potent suppressor of B cell activation. PMID: 24874925
    28. This study represents the first description of a significant role of myeloid KLF2 in neuroinflammation. PMID: 25052583
    29. KLF2 is a rate-limiting transcription factor that can be targeted to enhance regulatory T-cell production. PMID: 24979767
    30. The thromboprotective effect of bortezomib is KLF2 dependent. PMID: 24771858
    31. a novel link between KLF2-induced hepatic triglyceride accumulation and the expression of CD36. PMID: 23861552
    32. The present study explores the importance of KLF2 downregulation and reveals that the loss of KLF2 controls a select portion of the CD8 effector T cell transcriptional program. PMID: 24155966
    33. Study defines the roles of KLF2 and KLF4 in the embryonic development of blood vessels. It indicates that the two genes interact to maintain an intact endothelial layer. KLF2 and KLF4 positively regulate the eNOS, VEGFR2 and occludin genes. PMID: 24261709
    34. Kruppel-like factor 2 might mediate the rapamycin-induced arterial thrombosis in vivo. PMID: 23876886
    35. Data indicate taht regulation of KLF2 and S1P1 (S1pr1) provides a switch that dictates whether CD8(+) T cells commit to recirculating or tissue-resident memory populations. PMID: 24162775
    36. Plaque vulnerability correlated negatively with KLF2 but positively with PAR-1. Upregulation of KLF2 and downregulation of PAR-1 could be direct or indirect effects of statin therapy. PMID: 23395513
    37. IL-17 suppresses expression of PPARgamma, C/EBPalpha, KLF15, a pro-adipogenic transcription factor, and enhances expression of KLF2 and KLF3, which are anti-adipogenic. PMID: 23332504
    38. Echocardiography of KLF2-/- embryos indicates that they have abnormal heart function compared to wild-type. PMID: 23457456
    39. KLF2 protects blood-brain barrier through regulation of occludin. PMID: 23335794
    40. This study documents a role for myeloid KLF2 expression in modulating atherosclerosis. PMID: 22474254
    41. The data provide new insights and evidences of KLF2-mediated transcriptional regulation of arthritis via modulation of monocyte differentiation and function. PMID: 22280353
    42. Thioredoxin interacting protein promotes endothelial cell inflammation in response to disturbed flow by increasing leukocyte adhesion and repressing Kruppel-like factor 2. PMID: 22267843
    43. Dopamine stabilizes tumor blood vessels by up-regulating angiopoietin 1 expression in pericytes and Kruppel-like factor-2 expression in tumor endothelial cells PMID: 22143796
    44. identify HIF-1alpha and KLF2 as critical regulators of gram-positive endotoxin-mediated sepsis. PMID: 22110137
    45. KLF2 directly transactivates the reelin promoter in erythroid cells. PMID: 21530336
    46. identify the Kruppel-like transcription factor 2 (KLF2) as a potent regulator of myeloid cell activation in vivo PMID: 21565532
    47. An ERK5/Sp1/Klf module plays a key role in the fusion process during skeletal muscle differentiation. PMID: 21316587
    48. KLF2 has a role in B cell homeostasis and plasma cell homing PMID: 21187409
    49. KLF2 plays a critical role in dictating normal subset differentiation and functional reactivity of mature B cells PMID: 21187410
    50. Although KLF2 has a direct and profound effect on expression of key trafficking molecules, such as sphingosine-1-phosphate receptor-1 (SIP1) and CD62L, transcription of cell cycle-related genes is only modestly influenced by endogenous KLF2. PMID: 21160050

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  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    Krueppel C2H2-type zinc-finger protein family
  • 组织特异性：
    Predominant expression in the lungs and spleen.
  • 数据库链接：

    KEGG: mmu:16598

    STRING: 10090.ENSMUSP00000064823

    UniGene: Mm.26938