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  4. Recombinant Mouse Krueppel-like factor 13 (Klf13)

Recombinant Mouse Krueppel-like factor 13 (Klf13)

  • 中文名称：
    小鼠Klf13重组蛋白
  • 货号：
    CSB-YP867506MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Klf13重组蛋白
  • 货号：
    CSB-EP867506MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Klf13重组蛋白
  • 货号：
    CSB-EP867506MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Klf13重组蛋白
  • 货号：
    CSB-BP867506MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Klf13重组蛋白
  • 货号：
    CSB-MP867506MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Klf13
  • Uniprot No.：
  • 别名：
    Klf13; Bteb3; Fklf2Krueppel-like factor 13; Basic transcription element-binding protein 3; BTE-binding protein 3; Erythroid transcription factor FKLF-2; RANTES factor of late activated T-lymphocytes 1; RFLAT-1; Transcription factor BTEB3
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-289
  • 氨基酸序列
    MAAAAYVDHF AAECLVSMSS RAVVHEPREG PEPRPEGAAA AAPTLPRVDE RRDGKDSASL FVVARILADL NQQAPAPAPA ERREGAAARK ARTPCRLPPA PPAPPPGPEP ASPGQAGAPA APPSPAWSEP EAALEQEPGP AGSGEPGLRQ RGRRGRSRAD LESPQRKHKC HYAGCEKVYG KSSHLKAHLR THTGERPFAC SWQECNKKFA RSDELARHYR THTGEKKFSC PICEKRFMRS DHLTKHARRH ANFHPGMLQR RGGGSRTGSL SDYSRSDASS PTISPASSP
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Transcription factor that activates expression from GC-rich minimal promoter regions, including genes in the cells of the erythroid lineage.
  • 基因功能参考文献：
    1. Methylation levels at cg07814318 also positively correlated with ghrelin levels. Moreover, expression of KLF13 was augmented in the brains of obese and starved mice PMID: 28194012
    2. These results established a novel role for GR and KLF13 signaling in adult cardiomyocytes with potential clinical implications for the prevention of cardiotoxicity induced heart failure. PMID: 27451392
    3. Results demonstrate lack of a causative relationship between endometrial KLF13 deficiency and lesion establishment in mice, and they support the broader participation of multiple signaling pathways in the pathology of endometriosis. PMID: 25904015
    4. KLF13 directly binds to IL-4 promoter regions and synergizes with c-Maf to positively regulate IL-4 expression. PMID: 24821970
    5. KLF13 sustains thymic memory-like CD8(+) T cells in BALB/c mice by regulating IL-4-generating invariant natural killer T cells. PMID: 21482696
    6. Data support cross-regulation among BMP2, KLF9, and KLF13 to maintain progesterone sensitivity in stromal cells undergoing differentiation and suggest that loss of this network compromises establishment of uterine receptivity and implantation success. PMID: 20410205
    7. KLF13 binds to multiple sites within the Bcl-X(L) promoter and results in decreased Bcl-X(L) promoter activity, making KLF13 a negative regulator of BCL-X(L). PMID: 17442931
    8. These data indicate that KLF13 is involved in the normal control of erythropoiesis. PMID: 18285334
    9. findings show KLF13 is involved at multiple different checkpoints in B and T cell development that require signalling through the TCR, pre-BCR or mature BCR PMID: 18604172

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  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    Sp1 C2H2-type zinc-finger protein family
  • 组织特异性：
    Ubiquitous.
  • 数据库链接：

    KEGG: mmu:50794

    STRING: 10090.ENSMUSP00000067680

    UniGene: Mm.240473