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  4. Recombinant Mouse Killer cell lectin-like receptor 4 (Klra4), partial

Recombinant Mouse Killer cell lectin-like receptor 4 (Klra4), partial

  • 中文名称：
    小鼠Klra4重组蛋白
  • 货号：
    CSB-YP736732MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Klra4重组蛋白
  • 货号：
    CSB-EP736732MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Klra4重组蛋白
  • 货号：
    CSB-EP736732MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Klra4重组蛋白
  • 货号：
    CSB-BP736732MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Klra4重组蛋白
  • 货号：
    CSB-MP736732MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Klra4
  • Uniprot No.：
  • 别名：
    Klra4; Ly-49d; Ly49-d; Ly49d; Killer cell lectin-like receptor 4; Lymphocyte antigen 49d; Ly-49d; T-cell surface glycoprotein Ly-49D
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Receptor on natural killer (NK) cells for class I MHC.
  • 基因功能参考文献：
    1. this study shows that after mouse cytomegalovirus infection, Ly49D augmented IFN-gamma production by virus-specific Ly49H(+) NK cells and preferentially promoted the generation of memory Ly49H(+) NK cells PMID: 27438766
    2. The Ly49D activation receptor on mouse NK cells specifically recognizes the Chinese hamster histocompatibility class I molecule associated with Chinese hamster beta 2-microglobulin (beta 2m) and is not tolerized in murine beta 2m deficiency. PMID: 12077237
    3. Activating Ly49D NK cell receptors are provided a mechanism for release from inhibitory receptor blockade that enables them to become important initiators of microbial, antiviral, and antitumor immunity. PMID: 12574340
    4. Coexpression of a Ly49A transgene partially rescued NKT cell development in Ly49D/H2-Dd transgenics. PMID: 12682111
    5. Glycosylation of Ly-49D at amino acid residues NTT221-23 reduces receptor binding to H-2Dd tetramers and may represent a mechanism by which natural killer cells regulate affinity for host class I ligands. PMID: 14530347
    6. The MHC class I receptor Ly49D expressed on immature B cells recognizes MHC class I on peripheral tissues, inducing secretion of low levels of IFN-gamma and thereby down-regulating immature B cell homing to the lymph nodes or to sites of inflammation. PMID: 14568937
    7. Ly49D stimulation triggers cellular activation of CD4 and CD8 populations; Ly49D recognizes the classical hamster class I molecule Hm1-C4 on CHO cells, as demonstrated by the killing of Hm1-C4-transfected thymoma cells by Ly49D cytotoxic T cells. PMID: 19109149
    8. these data demonstrate that DAP10 does associate with Ly49H and Ly49D in primary NK cells. PMID: 19247984

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  • 亚细胞定位：
    Cell membrane; Single-pass type II membrane protein.
  • 数据库链接：

    KEGG: mmu:16635

    STRING: 10090.ENSMUSP00000114004

    UniGene: Mm.333431