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  4. Recombinant Mouse Kelch repeat and BTB domain-containing protein 5 (Kbtbd5)

Recombinant Mouse Kelch repeat and BTB domain-containing protein 5 (Kbtbd5)

  • 中文名称：
    小鼠Klhl40重组蛋白
  • 货号：
    CSB-YP875223MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Klhl40重组蛋白
  • 货号：
    CSB-EP875223MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Klhl40重组蛋白
  • 货号：
    CSB-EP875223MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Klhl40重组蛋白
  • 货号：
    CSB-BP875223MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Klhl40重组蛋白
  • 货号：
    CSB-MP875223MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Klhl40
  • Uniprot No.：
  • 别名：
    Klhl40; Kbtbd5; Kelch-like protein 40; Kelch repeat and BTB domain-containing protein 5
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-621
  • 氨基酸序列
    MTLGLEQAEE QRLYQQTLLQ DGLKDMLDHG KFLDCVVRVG EREFPCHRLV LAACSPYFRA RFLAEPDSAG EVRLEEVSPD VVSQVLHYLY TSEIALDEAS VQDLFAAAHR FQIPSIFTIC VSFLQKRLCL ANCLAVFRLG LLLDCARLAV AARDFICARF PLVARDNDFL GLSADELIAI ISSDGLNVEK EEAVFEAVMR WASSGDAEAQ AERQRALPTV FESVRCRLLP RAFLETRVER HPLVRSQPEL LRKVQMVKDA HEGRLTTLRK KKKEKGEQTA RAKEANQGTE DTKAEDDEER VLPGILNDTL RFGMFLQDLI FMISEEGAVA YDPAANECYC ASLSTQIPKN HVSLVTKENQ VFVAGGLFYN EDNKEDPMSA YFLQFDHLDS EWLGMPPLPS PRCLFGLGEA LNAIYVVGGR ELKDSEDSLD SVLCYDRLSF KWGESDPLPY AVYGHTVLSH MDLVYVIGGK GKDRKCLNKM CVYDPKKFEW KELAPMQTAR SLFGATVHDG RIFVAAGVTD TGLTSSSEVY SIADNKWTSF EAFPQERSSL SLVSLAGTLY ALGGFATLET ESGELVPTEL NDIWRYNEDE KKWEGVLREI AYAAGATFLP VRLNVVRLTK M
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a key regulator of skeletal muscle development. The BCR(KLHL40) complex acts by mediating ubiquitination and degradation of TFDP1, thereby regulating the activity of the E2F:DP transcription factor complex. Promotes stabilization of LMOD3 by acting as a negative regulator of LMOD3 ubiquitination; the molecular process by which it negatively regulates ubiquitination of LMOD3 is however unclear.
  • 基因功能参考文献：
    1. Kbtbd5 regulates skeletal muscle myogenesis through the regulation of E2F1-DP1 activity PMID: 25940086
    2. NEB and LMOD3 were reduced in skeletal muscle of Klhl40-/- mice, providing a potential basis for the development of experimental nemaline myopathy. PMID: 24960163
    3. we have demonstrated that Kbtbd5 is the direct downstream target gene of the Myod family and regulates myogenic differentiation. PMID: 24361185
  • 亚细胞定位：
    Cytoplasm. Cytoplasm, myofibril, sarcomere, A band. Cytoplasm, myofibril, sarcomere, I band.
  • 蛋白家族：
    KLHL40 family
  • 组织特异性：
    Specifically expressed in skeletal muscles in embryonic, neonatal and adults. Expressed in various types of muscles, including extensor digitorum longus, gastrocnemius, soleus, diaphragm, masseter and heart (at protein level). Not detected in brain, liver
  • 数据库链接：

    KEGG: mmu:72330

    STRING: 10090.ENSMUSP00000095873

    UniGene: Mm.45734