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  4. Recombinant Mouse Junctional adhesion molecule C (Jam3), partial

Recombinant Mouse Junctional adhesion molecule C (Jam3), partial

  • 货号：
    CSB-YP866709MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP866709MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP866709MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP866709MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP866709MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    Jam3Junctional adhesion molecule C; JAM-C; JAM-2; Junctional adhesion molecule 3; JAM-3) [Cleaved into: Soluble form of JAM-C; sJAM-C)]
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Junctional adhesion protein that mediates heterotypic cell-cell interactions with its cognate receptor JAM2 to regulate different cellular processes. Plays a role in homing and mobilization of hematopoietic stem and progenitor cells within the bone marrow. At the surface of bone marrow stromal cells, it contributes to the retention of the hematopoietic stem and progenitor cells expressing JAM3. Plays a central role in leukocytes extravasation by facilitating transmigration through the endothelium. Plays a role in spermatogenesis where JAM2 and JAM3, which are respectively expressed by Sertoli and germ cells, mediate an interaction between both cell types and play an essential role in the anchorage of germ cells onto Sertoli cells and the assembly of cell polarity complexes during spermatid differentiation. Also functions as a counter-receptor for ITGAM, mediating leukocyte-platelet interactions and is involved in the regulation of transepithelial migration of polymorphonuclear neutrophils (PMN). Plays a role in angiogenesis. Plays a role in the regulation of cell migration. During myogenesis, it is involved in myocyte fusion.; Promotes chemotaxis of vascular endothelial cells and stimulates angiogenesis.
  • 基因功能参考文献：
    1. the dimerization sites E66-K68 of JAM-C affected cell adhesion, polarization and migration and are essential for tumor cell metastasis. PMID: 29378216
    2. JAM-C plays an important role in maintaining VEGR2 expression to promote retinal pigment epithelial cell survival under oxidative stress. PMID: 28203682
    3. JAM-B/JAM-C mediated interaction between endothelial cells and stellate cells stabilizes vessel walls and may control the sinusoidal diameter. PMID: 27111582
    4. Study provides evidence that JAM-C downregulation may contribute to acute pancreatitis-associated lung injury via reverse transendothelial migration of neutrophils. PMID: 26841848
    5. Endothelial-specific deletion of JAM-C promoted endothelial cell sprouting, and consequently vessel normalisation and revascularisation of the hypoxic retina without altering pathologic neovascularisation. PMID: 26311310
    6. JAM-C blockade can finely-tune the innate cell migration and accelerate the consequent immune response to L. major without changing the type of the T helper cell response. PMID: 25474593
    7. Function of Jam-B/Jam-C interaction in homing and mobilization of human and mouse hematopoietic stem and progenitor cells. PMID: 24357068
    8. These findings provide evidence for a role for endothelial cell JAM-C in tumor growth and aggressiveness as well as recruitment of pericytes to newly formed blood vessels in a model of ovarian cancer. PMID: 23825230
    9. JAM-C might be involved in the final steps of trafficking and transmigration of antigen-specific autoaggressive T-cells to the islets of Langerhans. PMID: 23372751
    10. study suggests that JAM-C(-/-) C57BL/6 mice model the important role for JAM-C in brain development and CSF homeostasis as recently observed in humans with a loss-of-function mutation in JAM-C PMID: 23029139
    11. Data show that junctional adhesion molecule-B (JAM-B) expressed by endothelial cells contributes to murine B16 melanoma cells metastasis through its interaction with junctional adhesion molecule-C (JAM-C) on tumor cells. PMID: 23068611
    12. Results indicate that in vivo JAM-C shows enrichment at the apical surface and therefore is asymmetrically distributed during cell divisions. PMID: 22114908
    13. Data indicate deletion of JAM-C in deletion of JAM-C in Schwann cells (SCs) (JAM-C SC KO) mice showed electrophysiological defects, muscular weakness, and hypersensitivity to mechanical stimuli. PMID: 22090315
    14. Endothelial cell JAM-C has a key role in supporting luminal-to-abluminal migration of neutrophils in vivo, suggsting that reverse transepithial cell migration of neutrophils can contribute to the dissemination of systemic inflammation. PMID: 21706006
    15. Thrombomodulin and platelet-derived growth factor receptor alpha (PDGFRalpha) identify a population of fibroblastic reticular cells in lymph nodes where chemokine secretion is controlled by JAM-C. PMID: 21685324
    16. JAM-C(-/-) mice as well as endothelial-specific JAM-C-deficient mice displayed significantly decreased B16 melanoma cell metastasis to the lung, whereas treatment of mice with soluble JAM-C prevented melanoma lung metastasis PMID: 21593193
    17. a cell-surface protein of the immunoglobulin superfamily, junctional adhesion molecule-C (JAM-C), is critically required for the differentiation of round spermatids into spermatozoa in mice [JAM-C] PMID: 15372036
    18. JAM-C participates in neutrophil transmigration and thereby provides a novel molecular target for antagonizing interactions between vascular cells that promote inflammatory vascular pathologies PMID: 15485832
    19. JAM-C is up-regulated by oxLDL and may thereby contribute to increased inflammatory cell recruitment during atherosclerosis PMID: 16195363
    20. Interactions with JAM-B and -C are essential for development of cutaneous inflammation. PMID: 16297198
    21. JAM-C has a role in controlling epithelial cell conversion from a static, polarized state to a pro-migratory phenotype PMID: 17099249
    22. the expression of JAM-C promotes metastasis by enhancing both the adhesion of cancer cells to extracellular matrices and the subsequent invasion PMID: 17227766
    23. JAM-C has a minimal role, if any, in polymorphonuclear leukocyte transmigration. PMID: 17442972
    24. The results of these studies suggest a role for JAM-C in the pathogenesis of arthritis. PMID: 17612407
    25. blockade of JAM-B/-C interaction reduced monocyte numbers in the extravascular compartment through increased reverse transmigration rather than by reduced transmigration PMID: 17625065
    26. Jam-C was detected in tight junctions of retinal pigment epithelium (RPE) and at the outer limiting membrane (OLM) in the specialized adherens junctions between Muller and photoreceptor cells. PMID: 17853450
    27. study shows JAM-C is expressed in peripheral nerves & expression is localized to Schwann cells at junctions between adjoining myelin end loops; sciatic nerves from JAM-C-deficient mice had loss of integrity of myelin sheath & defective nerve conduction PMID: 18048693
    28. JAM-C plays a role in controlling myeloid progenitor generation in the bone marrow. PMID: 19109565
    29. JAM-C deficiency affects the adaptive humoral immune response against pathogens, in addition to the innate immune system PMID: 19342649
    30. role of JAM-3 in cardiac development studied in JAM-C deleted mice; mice have normal cardiac structure & function, indicating haplo-insufficiency of JAM-3 is unlikely to cause congenital heart defects that occur in 11q- patients PMID: 19533782
    31. role for endothelial cell JAM-C in mediating leukocyte adhesion and transmigration in response to I/R injury. PMID: 19574560

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  • 亚细胞定位：
    Cell membrane; Single-pass type I membrane protein. Cell junction. Cell junction, desmosome. Cell junction, tight junction.; [Soluble form of JAM-C]: Secreted.
  • 蛋白家族：
    Immunoglobulin superfamily
  • 组织特异性：
    Colocalizes with Jam2 near the lumen of seminiferous tubulues. Detected at junctional plaques that correspond to cell-cell contacts between spermatids and Sertoli cells. Detected on endothelial cells, in brain vessels and kidney glomeruli (at protein leve
  • 数据库链接：

    KEGG: mmu:83964

    STRING: 10090.ENSMUSP00000034472

    UniGene: Mm.28770