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  4. Recombinant Mouse Iroquois-class homeodomain protein IRX-5 (Irx5)

Recombinant Mouse Iroquois-class homeodomain protein IRX-5 (Irx5)

  • 中文名称：
    小鼠Irx5重组蛋白
  • 货号：
    CSB-YP888342MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Irx5重组蛋白
  • 货号：
    CSB-EP888342MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Irx5重组蛋白
  • 货号：
    CSB-EP888342MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Irx5重组蛋白
  • 货号：
    CSB-BP888342MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Irx5重组蛋白
  • 货号：
    CSB-MP888342MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Irx5
  • Uniprot No.：
  • 别名：
    Irx5; Irxb2; Iroquois-class homeodomain protein IRX-5; Homeodomain protein IRXB2; Iroquois homeobox protein 5
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-484
  • 氨基酸序列
    MSYPQGYLYQ PSASLALYSC PAYSTSVISG PRTDELGRSS SGSAFSPYAG STAFTAPSPG YNSHLQYGAD PAAAAAAAFS YVGSPYDHTP GMAGSLGYHP YAAPLGSYPY GDPAYRKNAT RDATATLKAW LNEHRKNPYP TKGEKIMLAI ITKMTLTQVS TWFANARRRL KKENKMTWTP RNRSEDEEEE ENIDLEKNDE DEPQKPEDKG DLEGPESGGA EQKATAGCER LQGPLSPAGK ETEGSLSDSD FKESSSEGRH DELPRPPRAG ESSPAGPATA RLAEDAGPHY PASVPAPGPH PSAGELPPGS GGSSVIHSPP PPPPPPPAVL AKPKLWSLAE IATSSDKVKD GGGGSEGSPC PPCPGPMGGQ TLGGSRASPA PAPARSPSAQ CPFPGGTVLS RPLYYTAPFY PGYTNYGSFG HLHGHPGPGP SPTAGPGSHF NGLNQTVLNR ADVLAKDPKM LRSQSQLDLC KDSPYELKKG MSDI
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Establishes the cardiac repolarization gradient by its repressive actions on the KCND2 potassium-channel gene. Required for retinal cone bipolar cell differentiation. May regulate contrast adaptation in the retina and control specific aspects of visual function in circuits of the mammalian retina. Involved in craniofacial and gonadal development. Modulates the migration of progenitor cell populations in branchial arches and gonads by repressing CXCL12.
  • 基因功能参考文献：
    1. Irx3 and Irx5 (Irx3/5) are essential in the initiating limb bud to specify progenitors of the femur, tibia, and digit 1. PMID: 24726282
    2. postnatal Irx3 activity can be repressed by Irx5 PMID: 22992950
    3. Regulates the development of type 2 and type 3 cone bipolar cells independently of visual system homeobox 1 (Vsx-1). PMID: 16182275
    4. Irx5 establishes the cardiac ventricular repolarization gradient. PMID: 16239150
    5. Iroquois related homeobox 5 (Irx5) transcription factor controls specific aspects of visual function in circuits of the mammalian retina. PMID: 18322081

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  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    TALE/IRO homeobox family
  • 组织特异性：
    Not expressed in the developing metanephric kidney or adult kidney.
  • 数据库链接：

    KEGG: mmu:54352

    STRING: 10090.ENSMUSP00000034184

    UniGene: Mm.101153