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  4. Recombinant Mouse Interleukin-22 receptor subunit alpha-2 (Il22ra2)

Recombinant Mouse Interleukin-22 receptor subunit alpha-2 (Il22ra2)

  • 货号：
    CSB-YP772164MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP772164MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP772164MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP772164MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP772164MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    Il22ra2Interleukin-22 receptor subunit alpha-2; IL-22 receptor subunit alpha-2; IL-22R-alpha-2; IL-22RA2; Cytokine receptor family type 2; soluble 1; CRF2-S1; Interleukin-22-binding protein; IL-22BP; IL22BP; ZcytoR16
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    full length protein
  • 表达区域：
    21-230
  • 氨基酸序列
    IQPARVSLTP QKVRFQSRNF HNILHWQAGS SLPSNNSIYF VQYKMYGQSQ WEDKVDCWGT TALFCDLTNE TLDPYELYYG RVMTACAGRH SAWTRTPRFT PWWETKLDPP VVTITRVNAS LRVLLRPPEL PNRNQSGKNA SMETYYGLVY RVFTINNSLE KEQKAYEGTQ RAVEIEGLIP HSSYCVVAEM YQPMFDRRSP RSKERCVHIP
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Receptor for IL22. Binds to IL22, prevents interaction with the functional IL-22R complex and blocks the activity of IL22 (in vitro). May play an important role as an IL22 antagonist in the regulation of inflammatory responses.
  • 基因功能参考文献：
    1. limits the pathological manifestations in models of allergic contact dermatitis and psoriasis PMID: 27676439
    2. Il22bp-deficient mice were more susceptible to acute liver damage in models of acute liver damage induced by ischemia reperfusion and acetaminophen administration. IL-22BP plays a protective role in acute liver damage, via controlling IL-22-induced Cxcl10 expression. PMID: 29109123
    3. IL-22BP promotes bacterial uptake into Peyer's patches by influencing follicle-associated epithelium gene expression and function. PMID: 28512157
    4. IL22RA2 KO displayed a less severe EAE course, less demyelination and less infiltration of immune cells in the CNS. PMID: 25008863
    5. the IL-22-IL-22BP axis critically regulates intestinal tissue repair and tumorigenesis in the colon PMID: 23075849
    6. cloning and characterization; gene encodes a protein of 230 amino acids that share 67.1% amino-acid sequence identity with human IL-22 binding protein; upregulated by LPS stimulation in monocytes PMID: 12700595

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  • 亚细胞定位：
    Secreted.
  • 蛋白家族：
    Type II cytokine receptor family
  • 组织特异性：
    Highly expressed in lymph nodes and at lower levels in lung, spleen, and thymus. Not expressed in kidney, liver and heart.
  • 数据库链接：

    KEGG: mmu:237310

    STRING: 10090.ENSMUSP00000042642

    UniGene: Mm.331979