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  4. Recombinant Mouse Interleukin-19 (Il19)

Recombinant Mouse Interleukin-19 (Il19)

  • 货号：
    CSB-YP810617MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP810617MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP810617MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP810617MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP810617MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    Il19Interleukin-19; IL-19
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    25-176
  • 氨基酸序列
    LRRCLI SVDMRLIEKS FHEIKRAMQT KDTFKNVTIL SLENLRSIKP GDVCCMTNNL LTFYRDRVFQ DHQERSLEVL RRISSIANSF LCVQKSLERC QVHRQCNCSQ EATNATRIIH DNYNQLEVSS AALKSLGELN ILLAWIDRNH LETPAA
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    May play some important roles in inflammatory responses. Up-regulates IL-6 and TNF-alpha and induces apoptosis.
  • 基因功能参考文献：
    1. Data, including data from studies using knockout mice, suggest that interleukin-19 suppresses hapten-dependent skin inflammation in elicitation phase of contact hypersensitivity. PMID: 29386478
    2. Attenuated colitis in IL-19-deficient animals was associated with reduced numbers of IL-6-producing macrophages in the inflamed colonic lamina propria. Microbial-driven expression of IL-19 by intestinal macrophages may contribute to the pathogenesis of inflammatory bowel disease. PMID: 28864472
    3. IL-19 can promote angiogenesis in the absence of hypoxia by at least two distinct mechanisms: 1) direct effects on vascular cells and 2) indirect effects by stimulation of macrophages. PMID: 27053520
    4. IL-19 plays an anti-inflammatory role in the Th2-mediated colitis model. PMID: 27942772
    5. microglia may self-limit their inflammatory response by producing the negative regulator IL-19. PMID: 25794104
    6. Lack of IL-19 exacerbates intimal hyperplasia PMID: 24814101
    7. we delineate the detailed molecular pathway for IL-4 up-regulation of IL-19 in keratinocytes, which may play an important role in AD pathogenesis. PMID: 24943510
    8. Il-19 expression is increased in astrocytes following bacterial challenge. PMID: 24677051
    9. IL-19 is important for cutaneous wound healing because it upregulates KGF expression. PMID: 23582717
    10. IL-19 is a potent inhibitor of experimental atherosclerosis. PMID: 23950143
    11. IL-19 is pivotal in the pathogenesis of breast cancer. PMID: 22186257
    12. endogenous IL-19 is a constituent of the regulome that controls both processes in vivo PMID: 22110701
    13. IL-19 drives pathogenic innate immune responses in the colon. PMID: 19834971
    14. In a dust mite-induced murine model of asthma, the IL-19 level in asthmatic BALB/cJ mice is twice that of healthy control mice. PMID: 15557163

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  • 亚细胞定位：
    Secreted.
  • 蛋白家族：
    IL-10 family
  • 数据库链接：

    KEGG: mmu:329244

    STRING: 10090.ENSMUSP00000016668

    UniGene: Mm.131480