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  4. Recombinant Mouse Interferon-related developmental regulator 1 (Ifrd1)

Recombinant Mouse Interferon-related developmental regulator 1 (Ifrd1)

  • 货号：
    CSB-YP011069MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP011069MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP011069MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP011069MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP011069MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Ifrd1
  • Uniprot No.：
  • 别名：
    Ifrd1; Tis7; Interferon-related developmental regulator 1; Nerve growth factor-inducible protein PC4; TPA-induced sequence 7; TIS7 protein
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full length protein
  • 表达区域：
    1-449
  • 氨基酸序列
    MPKNKKRNAP HRGGGGGGGS GAATSAATAG GPHRTVQPFS DEDASIETMS HCSGYSDPSS FAEDGPEVLD EEGTQEDLEY KLKGLIDLTL DKSAKTRQAA LEGLKNALSS KVLYEFVLER RMTLTDSIER CLKKGKSDEQ RAAAAVASVL CIQLGPGFES EEILKTLGPI LKKIICDGAA SIQARQTCAT CFGVCCFIAT DDITELYSTL ECFENIFTKS YLKEKDTNVT CSTPNTVLHI SSLLAWTLLL TICPINEVKK KLELHFHKLP SLLSCDDVNM RIAAGESLAL LFELARGMES DFFYEDMDSL TQMLRALATD GNKHRAKVDK RKQRSVFRDV LRAVEERDFP TETVKFGPER MYIDSWVKKH TYDTFKEVLG SGMQYHLQTN EFLRNVFELG PPVMLDAATL KTMKISRFER HLYNSAAFKA RTKARSKCRD KRADVGEFL
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Could play a role in regulating gene activity in the proliferative and/or differentiative pathways induced by NGF. May be an autocrine factor that attenuates or amplifies the initial ligand-induced signal.
  • 基因功能参考文献：
    1. adrenergic stimulation induced complex formation between Ifrd1, Sp1 and mSIN3B, which is a component of the SIN complex containing histone deacetylase, in brown adipocytes. These findings, therefore, suggest that Ifrd1 could be a pivotal negative regulator of sympathetic regulation of thermogenic and mitochondrial gene expression in brown adipocytes by interacting with Sp1 and the mSIN3 complex. PMID: 28107769
    2. Ifrd1 has a pivotal role in bone homeostasis through its expression in osteoblasts in vivo and represents a therapeutic target for bone diseases. PMID: 26391411
    3. High-fat diet feeding in the setting of tis7 deletion resulted in postresection anastomotic inflammation and small bowel obstruction. PMID: 25059825
    4. TIS7 predominantly interacted with beta-catenin in the nucleus. PMID: 23517917
    5. This work provides evidence for the first time of reduced level of IFRD1 protein in murine and human F508del-CFTR airway epithelial cell models. PMID: 21723850
    6. PC4 plays a role in muscle differentiation by controlling the MyoD pathway through multiple mechanisms, and as such, it positively regulates regenerative myogenesis. PMID: 21127072
    7. altered postresection adaptive responses of Tis7 knockout mice in short bowel syndrome model; results suggest a novel physiologic function for Tis7 in gut as global regulator of lipid absorption/metabolism and epithelial cell proliferation PMID: 20861213
    8. TIS7 protein interacts with several proteins of the SIN3 complex (mSin3B, HDAC1, N-CoR and SAP30. TIS7 is a transcriptional co-repressor affecting expression of specific genes in a HDAC-activity-dependent manner during cell fate decisions. PMID: 12198164
    9. Its expression may be involved in differentiation of neuronal progenitor cells to spiral ganglion cells by the initial sound input. PMID: 12451703
    10. Results suggest that TIS7 is not essential for mouse development but plays a novel regulatory role during adult muscle regeneration. PMID: 15060170
    11. TIS7 is a unique mediator of nutrient absorptive and metabolic adaptation following gut resection PMID: 16085642
    12. identification of IFRD1 as a modifier of cystic fibrosis lung disease severity PMID: 19242412
    13. This reference shows the cloning and the sequence of the original IFRD1 homolog isolated in mouse as TPA-inducible immediate early gene (named Tis7). PMID: 2797820
    14. The gene IFRD1/PC4 is required for muscle differentiation. Inhibition of PC4 expression in myoblasts prevents morphological differentiation, impairing myogenin and myosin gene expression. This finding has been confirmed by gene knockout in mice. PMID: 7756174

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  • 蛋白家族：
    IFRD family
  • 数据库链接：

    KEGG: mmu:15982

    STRING: 10090.ENSMUSP00000001672

    UniGene: Mm.168