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  4. Recombinant Mouse Interferon lambda-3 (Ifnl3)

Recombinant Mouse Interferon lambda-3 (Ifnl3)

  • 货号：
    CSB-YP807507MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP807507MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP807507MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP807507MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP807507MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    Ifnl3; Il28; Il28bInterferon lambda-3; IFN-lambda-3; Interleukin-28B; IL-28B
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    20-193
  • 氨基酸序列
    D PVPRATRLPV EAKDCHIAQF KSLSPKELQA FKKAKGAIEK RLLEKDMRCS SHLISRAWDL KQLQVQERPK ALQAEVALTL KVWENINDSA LTTILGQPLH TLSHIHSQLQ TCTQLQATAE PKPPSRRLSR WLHRLQEAQS KETPGCLEDS VTSNLFQLLL RDLKCVASGD QCV
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Cytokine with antiviral, antitumour and immunomodulatory activities. Plays a critical role in the antiviral host defense, predominantly in the epithelial tissues. Acts as a ligand for the heterodimeric class II cytokine receptor composed of IL10RB and IFNLR1, and receptor engagement leads to the activation of the JAK/STAT signaling pathway resulting in the expression of IFN-stimulated genes (ISG), which mediate the antiviral state. Has a restricted receptor distribution and therefore restricted targets: is primarily active in epithelial cells and this cell type-selective action is because of the epithelial cell-specific expression of its receptor IFNLR1. Seems not to be essential for early virus-activated host defense in vaginal infection, but plays an important role in Toll-like receptor (TLR)-induced antiviral defense. Plays a significant role in the antiviral immune defense in the intestinal epithelium. Exerts an immunomodulatory effect by up-regulating MHC class I antigen expression.
  • 基因功能参考文献：
    1. results suggest that IL-28B induces more mature NK cells to defend against viruses, in addition to its direct antiviral activity PMID: 28637903
    2. IL-28B down-regulates Tregs following subunit vaccine ESAT6-Ag85B-Mpt64(190-198)-Mtb8.4-HspX vaccination but does not improve the protective immune responses. PMID: 26521300
    3. the role of IFN-lambda in IDO regulation was investigated after influenza infection of respiratory epithelial cells. PMID: 25756191
    4. Acritical role of IL-28 cytokines is in controlling T cell responses in vivo through the modulation of lung CD11c(+) DC function in experimental allergic asthma. PMID: 21538995
    5. IFN-lambda is involved in development and maintenance of oral tolerance in the intestines of mice. PMID: 21569774
    6. IFN-alpha, IFN-beta, and IFN-gamma were observed in the anterior segment of injected eyes through 72 hours and mRNA levels of IFN-beta and IFN-gamma were increased in virus-infected eyes 48 to 120 hours after herpes simplex infection PMID: 21345992
    7. intranasal influenza A virus infection leads to the robust type III IFN induction in the lungs of both WT and IFNAR-/- mice PMID: 20739515
    8. IFN-lambda contributes to the control of viral infections in epithelial cells of both respiratory and gastrointestinal tracts. PMID: 20335250
    9. IFN-lambda inhibits HBV replication and blocks replication of a subgenomic and a full-length genomic HCV replicon PMID: 15731279
    10. IL-28A emerges as a key regulatory cytokine with pathogenic function in T-cell-mediated liver injury PMID: 17241885
    11. Type III interferon/IL-28 targets a specific subset of cells and contributes to the antiviral response evoked by Toll-like receptors, largely mediated by inducing an antiviral state in epithelial cells. PMID: 18250457
    12. IFN-lambda contributes to inborn resistance against viral pathogens infecting the lung but not the liver PMID: 18787692
    13. IL-28B can induce 100% protection from mortality after a lethal influenza challenge PMID: 19304955

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  • 亚细胞定位：
    Secreted.
  • 蛋白家族：
    Lambda interferon family
  • 数据库链接：

    KEGG: mmu:338374

    STRING: 10090.ENSMUSP00000077473

    UniGene: Mm.246799